Peroxisom Proliferator-Acivated Receptor Gamma (PPAR-g) (Western Blot Control) | MyBioSource MBS343106 product information

product summary

company name :

MyBioSource

product type :

protein

product name :

Peroxisom Proliferator-Acivated Receptor Gamma (PPAR-g) (Western Blot Control)

catalog :

MBS343106

quantity :

0.01 mg

price :

220 USD

more info or order :

MyBioSource product webpage

product information

catalog number :

MBS343106

products type :

Recombinant Protein

products full name :

Peroxisom Proliferator-Acivated Receptor Gamma (PPAR-g) (Western Blot Control)

products short name :

Peroxisom Proliferator-Acivated Receptor Gamma (PPAR-g)

products name syn :

PPARy, Peroxisome Proliferator-Activated Receptor, ?-isotype

other names :

peroxisome proliferator-activated receptor gamma isoform 1; Peroxisome proliferator-activated receptor gamma; peroxisome proliferator-activated receptor gamma; peroxisome proliferator activated receptor gamma; Nuclear receptor subfamily 1 group C member 3

products gene name :

PPAR-g

other gene names :

PPARG; PPARG; GLM1; CIMT1; NR1C3; PPARG1; PPARG2; PPARgamma; NR1C3; PPAR-gamma

uniprot entry name :

PPARG_HUMAN

sequence length :

477

purity :

>= 95% (SDS PAGE)

form :

Liquid

other info2 :

Buffer: Buffered 50% glycerol

products categories :

Recombinant Proteins; Peroxisome Proliferator-Activated Receptor Gamma

products description :

This nuclear receptor functions as a transcription factor and plays an important role in controlling differentiation and fatty acid metabolism. Activation of this receptor appears to be vital in modulating the expression of metabolic control proteins and consequently controlling fatty acid metabolism in cardiac muscle. This marker may be a useful drug target for therapeutic intervention in cardiac disease. PPAR gamma is also involved in the pathogenesis of important metabolic disorders such as obesity and non-insulin-dependent diabetes (NIDDM). Recombinant human PPAR gamma is expressed in E Coli with an amino-terminal hexahistidine tag. This product is not intended for therapeutic use.

products references :

Schiffrin, E.L. et al. (2003) Hypertension. 42(4): 664-68.

ncbi gi num :

116284373

ncbi acc num :

NP_619725.2

ncbi gb acc num :

NM_138711.3

uniprot acc num :

P37231

ncbi mol weight :

21,580 Da

ncbi pathways :

AMPK Signaling Pathway (989139); AMPK Signaling Pathway (992181); Adipogenesis Pathway (198832); Calcineurin-regulated NFAT-dependent Transcription In Lymphocytes Pathway (137993); Developmental Biology Pathway (1270302); Energy Metabolism Pathway (198907); Fatty Acid, Triacylglycerol, And Ketone Body Metabolism Pathway (1270010); Gene Expression Pathway (1269649); Generic Transcription Pathway (1269650); Huntington's Disease Pathway (83100)

ncbi summary :

This gene encodes a member of the peroxisome proliferator-activated receptor (PPAR) subfamily of nuclear receptors. PPARs form heterodimers with retinoid X receptors (RXRs) and these heterodimers regulate transcription of various genes. Three subtypes of PPARs are known: PPAR-alpha, PPAR-delta, and PPAR-gamma. The protein encoded by this gene is PPAR-gamma and is a regulator of adipocyte differentiation. Additionally, PPAR-gamma has been implicated in the pathology of numerous diseases including obesity, diabetes, atherosclerosis and cancer. Alternatively spliced transcript variants that encode different isoforms have been described. [provided by RefSeq, Jul 2008]

uniprot summary :

PPAR-gamma: a transcription factor, member of the nuclear hormone receptor superfamily. Receptor for hypolipidemic drugs and fatty acids. Preferentially expressed in adipocytes as well as in vascular smooth muscle cells and macrophage. Regulator of adipogenesis and lipid metabolism, modulates insulin sensitivity, cell proliferation and inflammation. Phosphorylated and inhibited by MAP kinase. Heterodimerizes with the retinoid X receptor. Interacts with NCOA6 coactivator, leading to a strong increase in transcription of target genes. Two splice-variant isoforms have been described. Protein type: DNA-binding; Nuclear receptor. Chromosomal Location of Human Ortholog: 3p25. Cellular Component: cytosol; Golgi apparatus; intracellular membrane-bound organelle; nucleoplasm; nucleus. Molecular Function: alpha-actinin binding; arachidonic acid binding; chromatin binding; DNA binding; drug binding; enzyme binding; identical protein binding; ligand-dependent nuclear receptor activity; ligand-dependent nuclear receptor transcription coactivator activity; prostaglandin receptor activity; protein binding; retinoid X receptor binding; sequence-specific DNA binding; transcription activator binding; transcription factor activity. Biological Process: caspase activation; cell fate commitment; cell maturation; cellular response to insulin stimulus; epithelial cell differentiation; glucose homeostasis; innate immune response; lipid homeostasis; lipid metabolic process; lipoprotein transport; long-chain fatty acid transport; low-density lipoprotein receptor biosynthetic process; monocyte differentiation; negative regulation of smooth muscle cell proliferation; negative regulation of transcription from RNA polymerase II promoter; negative regulation of transcription, DNA-dependent; placenta development; positive regulation of fat cell differentiation; positive regulation of transcription factor activity; positive regulation of transcription from RNA polymerase II promoter; positive regulation of transcription, DNA-dependent; regulation of blood pressure; regulation of circadian rhythm; response to lipid; response to low density lipoprotein stimulus; response to nutrient; response to retinoic acid; signal transduction; transcription initiation from RNA polymerase II promoter; white fat cell differentiation. Disease: Carotid Intimal Medial Thickness 1; Diabetes Mellitus, Noninsulin-dependent; Lipodystrophy, Familial Partial, Type 3; Obesity

size1 :

0.01 mg

price1 :

220 USD

more info or order :

MyBioSource product webpage