MyBioSource

protein

PPAR gamma

MBS343105

0.01 mg

200 USD

MBS343105

Recombinant Protein

PPAR gamma

PPAR gamma

PPARy; PPAR gamma; Peroxisom Proliferator-Acivated Receptor Gamma; Peroxisome Proliferator-Activated Receptor, gamma -isotype

peroxisome proliferator-activated receptor gamma isoform 1; Peroxisome proliferator-activated receptor gamma; peroxisome proliferator-activated receptor gamma; PPAR gamma; PPAR-gamma; OTTHUMP00000160185; OTTHUMP00000160186; OTTHUMP00000185030; OTTHUMP00000185032; OTTHUMP00000185034; OTTHUMP00000185036; OTTHUMP00000207750; nuclear receptor subfamily 1 group C member 3; peroxisome proliferator-activated receptor gamma 1; peroxisome proliferator-activated nuclear receptor gamma variant 1; peroxisome proliferator-activated receptor gamma; Nuclear receptor subfamily 1 group C member 3

PPARy

PPARG; PPARG; GLM1; CIMT1; NR1C3; PPARG1; PPARG2; PPARgamma; NR1C3

PPARG_HUMAN

505

>95% by SDS-PAGE

Liquid

Human Recombinant Protein

This nuclear receptor functions as a transcription factor and plays an important role in controlling differentiation and fatty acid metabolism. Activation of this receptor appears to be vital in modulating the expression of metabolic control proteins and consequently controlling fatty acid metabolism in cardiac muscle. This marker may be a useful drug target for therapeutic intervention in cardiac disease. PPAR gamma is also involved in the pathogenesis of important metabolic disorders such as obesity and non-insulin-dependent diabetes (NIDDM). Our recombinant human PPAR gamma is expressed in E. coli with an amino-terminal hexahistidine tag. This product is for research use only and is not intended for diagnostic or therapeutic use.

Schiffrin, E.L. et al. (2003) Hypertension. 42(4): 664-68.

116284373

NP_619725.2

NM_138711.3

P37231

59.2 kDa

Adipogenesis Pathway 198832!!Calcineurin-regulated NFAT-dependent Transcription In Lymphocytes Pathway 137993!!Diabetes Pathways 105902!!Energy Metabolism Pathway 198907!!Gene Expression Pathway 105937!!Generic Transcription Pathway 105938!!Huntington's Disease Pathway 83100!!Huntington's Disease Pathway 512!!Noncanonical Wnt Signaling Pathway 169354!!Nuclear Receptor Transcription Pathway 105979

This gene encodes a member of the peroxisome proliferator-activated receptor (PPAR) subfamily of nuclear receptors. PPARs form heterodimers with retinoid X receptors (RXRs) and these heterodimers regulate transcription of various genes. Three subtypes of PPARs are known: PPAR-alpha, PPAR-delta, and PPAR-gamma. The protein encoded by this gene is PPAR-gamma and is a regulator of adipocyte differentiation. Additionally, PPAR-gamma has been implicated in the pathology of numerous diseases including obesity, diabetes, atherosclerosis and cancer. Alternatively spliced transcript variants that encode different isoforms have been described. [provided by RefSeq]

Function: Receptor that binds peroxisome proliferators such as hypolipidemic drugs and fatty acids. Once activated by a ligand, the receptor binds to a promoter element in the gene for acyl-CoA oxidase and activates its transcription. It therefore controls the peroxisomal beta-oxidation pathway of fatty acids. Key regulator of adipocyte differentiation and glucose homeostasis. Ref.1. Subunit structure: Forms a heterodimer with the retinoic acid receptor RXRA called adipocyte-specific transcription factor ARF6. Interacts with NCOA6 coactivator, leading to a strong increase in transcription of target genes. Interacts with coactivator PPARBP, leading to a mild increase in transcription of target genes. Interacts with FAM120B. Interacts with PRDM16. By similarity. Interacts with NOCA7 in a ligand-inducible manner. Interacts with NCOA1 LXXLL motifs. Interacts with TGFB1I1. Interacts with DNTTIP2. Interacts with PRMT2. Ref.15 Ref.17 Ref.18 Ref.19 Ref.20 Ref.22. Subcellular location: Nucleus. Tissue specificity: Highest expression in adipose tissue. Lower in skeletal muscle, spleen, heart and liver. Also detectable in placenta, lung and ovary. Ref.1. Polymorphism: Genetic variation in PPARG may influence body mass index (BMI) [. MIM:606641]. BMI reflects the amount of fat, lean mass, and body build.Genetic variations in PPARG influence the carotid intimal medial thickness (CIMT) [. MIM:609338]. CIMT is a measure of atherosclerosis that is independently associated with traditional atherosclerotic cardiovascular disease risk factors and coronary atherosclerotic burden. 35 to 45% of the variability in multivariable-adjusted CIMT is explained by genetic factors. Involvement in disease: Note=Defects in PPARG can lead to type 2 insulin-resistant diabetes and hyptertension. PPARG mutations may be associated with colon cancer.Defects in PPARG may be associated with susceptibility to obesity (OBESITY) [. MIM:601665]. It is a condition characterized by an increase of body weight beyond the limitation of skeletal and physical requirements, as the result of excessive accumulation of body fat. Ref.35Defects in PPARG are the cause of familial partial lipodystrophy type 3 (FPLD3) [. MIM:604367]. Familial partial lipodystrophies (FPLD) are a heterogeneous group of genetic disorders characterized by marked loss of subcutaneous (sc) fat from the extremities. Affected individuals show an increased preponderance of insulin resistance, diabetes mellitus and dyslipidemia. Ref.41 Ref.42Genetic variations in PPARG can be associated with susceptibility to glioma type 1 (GLM1) [. MIM:137800]. Gliomas are central nervous system neoplasms derived from glial cells and comprise astrocytomas, glioblastoma multiforme, oligodendrogliomas, and ependymomas. Note=Polymorphic PPARG alleles have been found to be significantly over-represented among a cohort of American patients with sporadic glioblastoma multiforme suggesting a possible contribution to disease susceptibility. Sequence similarities: Belongs to the nuclear hormone receptor family. NR1 subfamily.Contains 1 nuclear receptor DNA-binding domain. Sequence caution: The sequence AAN38992.2 differs from that shown. Reason: Erroneous initiation. Translation N-terminally extended.The sequence BAA23354.1 differs from that shown. Reason: Erroneous gene model prediction. The sequence BAF83270.1 differs from that shown. Reason: Erroneous initiation. Translation N-terminally extended.The sequence CAA62153.1 differs from that shown. Reason: Erroneous initiation. Translation N-terminally extended.

0.01 mg

200 USD