protein

Paraoxonase 2 (PO-2)

MBS343103

0.01 mg

220 USD

Recombinant Protein

Paraoxonase 2 (PO-2)

Paraoxonase 2 (PO-2)

PON 2, Serum paraoxonase/arylesterase 2, aryldialkylphosphatase 2, A-esterase 2, Aromatic esterase 2

paraoxonase 2; Serum paraoxonase/arylesterase 2; serum paraoxonase/arylesterase 2; paraoxonase 2; Aromatic esterase 2; A-esterase 2; Serum aryldialkylphosphatase 2

PO-2

PON2; PON2; PON 2; A-esterase 2

PON2_HUMAN

354

>95% by SDS-PAGE

Liquid

Buffer: Buffered 50% glycerol

Recombinant Proteins; Paraoxonase 2

Paraoxonase 1 is involved in the detoxification of organophosphate insecticides such as parathion. Paraoxonase 1 may also confer protection against coronary artery disease by destroying proinflammatory oxidized lipids present in oxidized low-density lipoproteins (LDLs). Recombinant human PON1 is expressed in E Coli with an amino-terminal hexahistidine tag. This product is not intended for therapeutic use.

Rosenblat M. et al. (2003) Arterioscler Thromb Vasc Biol. 23(3): 468-74.

1333632

AAC41995.1

Q15165

37,996 Da

Metabolic Pathways (132956); Phase I, Non P450 Pathway (198854)

This gene encodes a member of the paraoxonase gene family, which includes three known members located adjacent to each other on the long arm of chromosome 7. The encoded protein is ubiquitously expressed in human tissues, membrane-bound, and may act as a cellular antioxidant, protecting cells from oxidative stress. Hydrolytic activity against acylhomoserine lactones, important bacterial quorum-sensing mediators, suggests the encoded protein may also play a role in defense responses to pathogenic bacteria. Mutations in this gene may be associated with vascular disease and a number of quantitative phenotypes related to diabetes. Alternatively spliced transcript variants encoding different isoforms have been described. [provided by RefSeq, Jul 2008]

PON2: Capable of hydrolyzing lactones and a number of aromatic carboxylic acid esters. Has antioxidant activity. Is not associated with high density lipoprotein. Prevents LDL lipid peroxidation, reverses the oxidation of mildly oxidized LDL, and inhibits the ability of MM-LDL to induce monocyte chemotaxis. Belongs to the paraoxonase family. 3 isoforms of the human protein are produced by alternative splicing. Protein type: EC 3.1.1.81; Motility/polarity/chemotaxis; EC 3.1.1.2; Hydrolase. Chromosomal Location of Human Ortholog: 7q21.3. Cellular Component: plasma membrane. Molecular Function: identical protein binding. Biological Process: aromatic compound catabolic process; response to toxin

0.01 mg

220 USD

0.1 mg

555

1 mg

2535