protein

Neurophil Gelatinase Associated Lipocalin (NGAL) (Western Blot Control)

MBS343100

0.01 mg

180 USD

Recombinant Protein

Neurophil Gelatinase Associated Lipocalin (NGAL) (Western Blot Control)

Neurophil Gelatinase Associated Lipocalin (NGAL)

NGAL

neutrophil gelatinase-associated lipocalin; Neutrophil gelatinase-associated lipocalin; neutrophil gelatinase-associated lipocalin; lipocalin 2; 25 kDa alpha-2-microglobulin-related subunit of MMP-9; Lipocalin-2; Oncogene 24p3; Siderocalin LCN2; p25

NGAL

LCN2; LCN2; p25; 24p3; MSFI; NGAL; HNL; NGAL; NGAL

NGAL_HUMAN

198

>= 95% (SDS PAGE)

Liquid

Buffer: Buffered 50% glycerol

Recombinant Proteins; Neutrophil Gelatinase Associated Lipocalin

The lipocalins are a family of around 25 proteins (including alpha 1-microglobulin and & b -lactoglobulin), which are characterized by their ability to bind small lipophilic substances in their hydrophobic core. They thereby serve as transporters of substances like retinal, biliverdins & prostaglandins. There are indications that NGAL is involved in modulation of the inflammatory response and is found in the plasma of patients after stroke. Recombinant human NGAL is expressed in E Coli with an amino-terminal hexahistidine tag. This product is not intended for therapeutic use.

Elneihoum, A.M. et al. (1996) Stroke 27(10): 1734-38.

38455402

NP_005555.2

NM_005564.4

P80188

22,457 Da

Iron Uptake And Transport Pathway (1269948); Transmembrane Transport Of Small Molecules Pathway (1269903)

This gene encodes a protein that belongs to the lipocalin family. Members of this family transport small hydrophobic molecules such as lipids, steroid hormones and retinoids. The protein encoded by this gene is a neutrophil gelatinase-associated lipocalin and plays a role in innate immunity by limiting bacterial growth as a result of sequestering iron-containing siderophores. The presence of this protein in blood and urine is an early biomarker of acute kidney injury. This protein is thought to be be involved in multiple cellular processes, including maintenance of skin homeostasis, and suppression of invasiveness and metastasis. Mice lacking this gene are more susceptible to bacterial infection than wild type mice. [provided by RefSeq, Sep 2015]

LCN2: Iron-trafficking protein involved in multiple processes such as apoptosis, innate immunity and renal development. Binds iron through association with 2,5-dihydroxybenzoic acid (2,5- DHBA), a siderophore that shares structural similarities with bacterial enterobactin, and delivers or removes iron from the cell, depending on the context. Iron-bound form (holo-24p3) is internalized following binding to the SLC22A17 (24p3R) receptor, leading to release of iron and subsequent increase of intracellular iron concentration. In contrast, association of the iron-free form (apo-24p3) with the SLC22A17 (24p3R) receptor is followed by association with an intracellular siderophore, iron chelation and iron transfer to the extracellular medium, thereby reducing intracellular iron concentration. Involved in apoptosis due to interleukin-3 (IL3) deprivation: iron-loaded form increases intracellular iron concentration without promoting apoptosis, while iron-free form decreases intracellular iron levels, inducing expression of the proapoptotic protein BCL2L11/BIM, resulting in apoptosis. Involved in innate immunity, possibly by sequestrating iron, leading to limit bacterial growth. Belongs to the calycin superfamily. Lipocalin family. 2 isoforms of the human protein are produced by alternative splicing. Protein type: Secreted, signal peptide; Secreted. Chromosomal Location of Human Ortholog: 9q34. Cellular Component: extracellular region; extracellular space. Molecular Function: iron ion binding. Biological Process: cellular iron ion homeostasis; innate immune response; siderophore transport

0.01 mg

180 USD