protein

Neuronal Specific Enolase (Western Blot Control)

MBS343098

0.01 mg

190 USD

Recombinant Protein

Neuronal Specific Enolase (Western Blot Control)

Neuronal Specific Enolase (Western Blot Control)

NSE; NSE; Neuronal specific enolase; EC. 4.2.1.11; 2-phospho-Dglycerate hydrolyase; enolase 2 (gamma neuronal); neuron specific enolase; neural enolase; enolase 2

neurone-specific enolase; Gamma-enolase; gamma-enolase; neural enolase; OTTHUMP00000239836; OTTHUMP00000239837; OTTHUMP00000239839; OTTHUMP00000239840; neuron-specific enolase; neurone-specific enolase; neuron specific gamma enolase; 2-phospho-D-glycerate hydrolyase; 2-phospho-D-glycerate hydro-lyase; enolase 2 (gamma, neuronal); 2-phospho-D-glycerate hydro-lyase; Enolase 2; Neural enolase; Neuron-specific enolase

NSE

ENO2; ENO2; NSE

ENOG_HUMAN

434

Single band on Western blot

Liquid. Supplied in 1x Laemmli Buffer (25mM Tris-HCl pH6.8, 50mM DTT, 1% (w/v) SDS, 0.1% (w/v) Bromophenol Blue, 2.5% Glycerol).

Human Recombinant Protein

NSE is the gamma gamma isoform of the glycolytic enzyme enolase and is expressed primarily in neurons, in normal and neoplastic neuroendocrine cells . NSE is a highly soluble cytoplasmic protein that is readily secreted into the CSF and serum following tissue damage. NSE shows neurotrophic and neuroprotective properties on a broad spectrum of central nervous system (CNS) neurons and binds in a calcium-dependent manner to cultured neocortical neurons promoting cell survival. Our recombinant NSE comprises a 433 amino acid fragment (2-434) corresponding to processed mature NSE protein and is expressed in E. coli with an aminoterminal hexahistidine tag. This product is for research use only and is not intended for diagnostic or therapeutic use.

Kaiser, E. et al.,(1989) Clin. Chim. Acta. 183 (1) :13-31.

930063

CAA31512.1

P09104

47,269 Da

Gluconeogenesis Pathway 106204!!Glucose Metabolism Pathway 106199!!Glycolysis Pathway 105911!!Glycolysis / Gluconeogenesis Pathway 82926!!Glycolysis / Gluconeogenesis Pathway 287!!Glycolysis And Gluconeogenesis Pathway 198814!!Metabolic Pathways 132956!!Metabolism Of Carbohydrates Pathway 106196!!RNA Degradation Pathway 117291!!RNA Degradation Pathway 116127

This gene encodes one of the three enolase isoenzymes found in mammals. This isoenzyme, a homodimer, is found in mature neurons and cells of neuronal origin. A switch from alpha enolase to gamma enolase occurs in neural tissue during development in rats and primates. [provided by RefSeq]

Function: Has neurotrophic and neuroprotective properties on a broad spectrum of central nervous system (CNS) neurons. Binds, in a calcium-dependent manner, to cultured neocortical neurons and promotes cell survival. Catalytic activity: 2-phospho-D-glycerate = phosphoenolpyruvate + H2O. Cofactor: Magnesium. Required for catalysis and for stabilizing the dimer. Pathway: Carbohydrate degradation; glycolysis; pyruvate from D-glyceraldehyde 3-phosphate: step 4/5. Subunit structure: Mammalian enolase is composed of 3 isozyme subunits, alpha, beta and gamma, which can form homodimers or heterodimers which are cell-type and development-specific. Subcellular location: Cytoplasm. By similarity. Cell membrane. By similarity. Note: Can translocate to the plasma membrane in either the homodimeric (alpha/alpha) or heterodimeric (alpha/gamma) form. Tissue specificity: The alpha/alpha homodimer is expressed in embryo and in most adult tissues. The alpha/beta heterodimer and the beta/beta homodimer are found in striated muscle, and the alpha/gamma heterodimer and the gamma/gamma homodimer in neurons. Developmental stage: During ontogenesis, there is a transition from the alpha/alpha homodimer to the alpha/beta heterodimer in striated muscle cells, and to the alpha/gamma heterodimer in nerve cells. Induction: Levels of ENO2 increase dramatically in cardiovascular accidents, cerebral trauma, brain tumors and Creutzfeldt-Jacob disease. Sequence similarities: Belongs to the enolase family. Sequence caution: The sequence AAA52388.1 differs from that shown. Reason: Erroneous initiation.

0.01 mg

190 USD