protein

Monoamine Oxidase B (MAOB)

MBS343091

0.01 mg

220 USD

Recombinant Protein

Monoamine Oxidase B (MAOB)

Monoamine Oxidase B (MAOB)

Amine oxidase [flavin-containing] B, Monoamine oxidase type B, MAOB, Mao Platelet, MAO Brain.

monoamine oxidase B, partial; Amine oxidase [flavin-containing] B; amine oxidase [flavin-containing] B; monoamine oxidase B; Monoamine oxidase type B; MAO-B

MAOB

MAOB; MAOB; MAO-B

AOFB_HUMAN

520

>95% by SDS-PAGE

Liquid

Buffer: Buffered 50% glycerol

Recombinant Proteins; Monoamine Oxidase B

Monoamine oxidase B (MAO-B) is a flavin-containing mitochondrial enzyme, which catalyzes the oxidative deamination of biogenic and xenobiotic monoamines. It regulates the metabolic degradation of catecholamines and serotonin in neural and other target tissues. MAO-B is found platelets and in dopamine-secreting neurons in the brain. Increased levels of MAO B that have been identified in brain of Alzheimer's patients. Monoamine oxidases (MAO B and MAO A) are well-known targets for antidepressant drugs and for drugs used to treat neurological disorders and aging diseases, such as Parkinson's and Alzheimer's disease. Recombinant MAO-B comprises a 488 amino acid fragment (2-489) corresponding to the cytoplasmic domain fragment of the mature MAO-B protein and is expressed in E Coli with an amino-terminal hexahistidine tag. This product is not intended for therapeutic use.

Binda, C. et al., Neurology 2006 67: S5-S7. Li, M. et al., Protei Expr Purif. 2002 24 (1): 152-62.

398415

AAB27229.1

P27338

46,539 Da

Alcoholism Pathway (585563); Alcoholism Pathway (587116); Alpha-synuclein Signaling Pathway (137913); Amine Oxidase Reactions Pathway (1270203); Amphetamine Addiction Pathway (547607); Amphetamine Addiction Pathway (550546); Arginine And Proline Metabolism Pathway (82957); Arginine And Proline Metabolism Pathway (323); Biogenic Amines Are Oxidatively Deaminated To Aldehydes By MAOA And MAOB Pathway (1270204); Biological Oxidations Pathway (1270189)

The protein encoded by this gene belongs to the flavin monoamine oxidase family. It is a enzyme located in the mitochondrial outer membrane. It catalyzes the oxidative deamination of biogenic and xenobiotic amines and plays an important role in the metabolism of neuroactive and vasoactive amines in the central nervous sysytem and peripheral tissues. This protein preferentially degrades benzylamine and phenylethylamine. [provided by RefSeq, Jul 2008]

MAOB: Catalyzes the oxidative deamination of biogenic and xenobiotic amines and has important functions in the metabolism of neuroactive and vasoactive amines in the central nervous system and peripheral tissues. MAOB preferentially degrades benzylamine and phenylethylamine. Belongs to the flavin monoamine oxidase family. Protein type: Amino Acid Metabolism - tyrosine; EC 1.4.3.4; Mitochondrial; Amino Acid Metabolism - histidine; Oxidoreductase; Amino Acid Metabolism - glycine, serine and threonine; Amino Acid Metabolism - phenylalanine; Xenobiotic Metabolism - drug metabolism - cytochrome P450; Amino Acid Metabolism - tryptophan; Membrane protein, integral; Amino Acid Metabolism - arginine and proline. Chromosomal Location of Human Ortholog: Xp11.23. Cellular Component: mitochondrial envelope; mitochondrial outer membrane; mitochondrion. Molecular Function: amine oxidase activity; electron carrier activity. Biological Process: dopamine catabolic process; substantia nigra development

0.01 mg

220 USD

0.1 mg

555

1 mg

2535