catalog number :
MBS343089
products type :
Recombinant Protein
products full name :
Mitochondrial Glycerol-3-Phosphate Dehydrogenase (mGPD)
products short name :
Mitochondrial Glycerol-3-Phosphate Dehydrogenase (mGPD)
products name syn :
Glycerol-3-Phosphate Dehydrogenase 2, GPD2, Glycerophosphate Dehydrognase-2 Ca(2+) - Responsive Mitochondrial FAD-Linked, Mitochondrial GPD, GPDM, GPD-M, GPDH-M, mtGPD, GDH2.
products gene name :
mGPD
purity :
>95% by SDS-PAGE
other info2 :
Buffer: Buffered 50% glycerol
products categories :
Recombinant Proteins; Mithochondrial Glycerol-3-Phosphate Dehydrogenase
products description :
Mitochondrial glycerol-3-phosphate dehydrogenase (mGPD) is a Ca2+-sensitive, FAD-binding protein, located on the outer surface of the inner mitochondrial membrane. mGPD catalyses the oxidation of glycerol-3-phosphate to dihydroxyacetone phosphate (DHAP) with concomitant reduction of the enzyme-bound FAD. Two isoforms have been described for mGPD. Isoform 1 comprises 727aa residues, whereas isoform 2 lacks 126aa residues of the N-terminus. Deficiency of mGPD appears to contribute to the impairment of glucose-stimulated insulin release in several animal models of non-insulin dependent diabetes mellitus. Recombinant mGPD comprises a 558 amino acid fragment (43-600) corresponding to the GlpA domain fragment of the mature mGPD protein and is expressed in E Coli with an amino-terminal hexahistidine tag. This product is not intended for therapeutic use.
products references :
Brown, L.J. et al., Gene 1996 172 (2): 309-12. Ferrer J. et al., Diabetes 1996 45 (2): 262-6.