L-Selectin | MyBioSource MBS343083 product information

product summary

request information :

company name :

MyBioSource

product type :

protein

product name :

L-Selectin

catalog :

MBS343083

quantity :

0.01 mg

price :

200 USD

more info or order :

MyBioSource product webpage

product information

catalog number :

MBS343083

products type :

Recombinant Protein

products full name :

L-Selectin

products short name :

L-Selectin

products name syn :

L-Selectin; Leukocyte Selectin, L-SEL, Leukocyte adhesion molecule LAM-1, Leukocyte cell adhesion molecule LECAM-1, TQ1, CD62L, Leukocyte surface antigen Leu-8, DREG, lymph node homing receptor LNHR, MEL-14

other names :

L-selectin; L-selectin; L-selectin; gp90-MEL; OTTHUMP00000032696; pln homing receptor; lymph node homing receptor; lymphocyte adhesion molecule 1; leukocyte surface antigen Leu-8; CD62 antigen-like family member L; leukocyte-endothelial cell adhesion molecule 1; selectin L; CD62 antigen-like family member L; Leukocyte adhesion molecule 1; LAM-1; Leukocyte surface antigen Leu-8; Leukocyte-endothelial cell adhesion molecule 1; LECAM1; Lymph node homing receptor; TQ1; gp90-MEL

other gene names :

SELL; SELL; TQ1; LAM1; LEU8; LNHR; LSEL; CD62L; LYAM1; PLNHR; LECAM1; LNHR; LYAM1

uniprot entry name :

LYAM1_HUMAN

sequence length :

372

purity :

>95% by SDS-PAGE

form :

Liquid

products categories :

Human Recombinant Protein

products description :

L-Selectin belongs to a family of divalent cationdependent carbohydrate-binding glycoproteins or adhesion molecules. L-Selectin is expressed constitutively on lymphocytes, monocytes and granulocytes and interacts specifically with carbohydrate groups on activated endothelial cells. L-Selectin may be shed by proteolytic cleavage and circulating levels in biological fluids may be used as an indicator of various pathological conditions. Our recombinant human L-selectin comprises a 294 amino acid fragment (39-332) corresponding to the mature L-Selectin extracellular domain and is expressed in E. coli with an amino-terminal hexahistidine tag. This product is for research use only and is not intended for diagnostic or therapeutic use.

products references :

Tedder, T.F et al. (1990) J. Immunol. 144 (2): 532-540. Schleiffenbaum, B. et al. (1992) J. Cell Biol. 119 (1): 229- 238.

ncbi gi num :

5852072

ncbi acc num :

CAB55488.1

uniprot acc num :

Q9UJ43

ncbi mol weight :

42,187 Da

ncbi pathways :

Adaptive Immunity Signaling Pathway 366160!!Cell Adhesion Molecules (CAMs) Pathway 83069!!Cell Adhesion Molecules (CAMs) Pathway 480!!Cell Surface Interactions At The Vascular Wall Pathway 106062!!Hemostasis Pathway 106028!!Immune System Pathway 106386!!Immunoregulatory Interactions Between A Lymphoid And A Non-Lymphoid Cell Pathway 106413

ncbi summary :

This gene encodes a cell surface adhesion molecule that belongs to a family of adhesion/homing receptors. The encoded protein contains a C-type lectin-like domain, a calcium-binding epidermal growth factor-like domain, and two short complement-like repeats. The gene product is required for binding and subsequent rolling of leucocytes on endothelial cells, facilitating their migration into secondary lymphoid organs and inflammation sites. Single-nucleotide polymorphisms in this gene have been associated with various diseases including immunoglobulin A nephropathy. Alternatively spliced transcript variants have been found for this gene. [provided by RefSeq]

uniprot summary :

Function: Cell surface adhesion protein. Mediates the adherence of lymphocytes to endothelial cells of high endothelial venules in peripheral lymph nodes. Promotes initial tethering and rolling of leukocytes in endothelia. Ref.10. Subunit structure: Interaction with PSGL1/SELPLG and PODXL2 is required for promoting recruitment and rolling of leukocytes. This interaction is dependent on the sialyl Lewis X glycan modification of PSGL1 and PODXL2, and tyrosine sulfation modifications of PSGL1. Sulfation on Y-51 of PSGL1 is important for L-selectin binding. Subcellular location: Membrane; Single-pass type I membrane protein. Tissue specificity: Expressed in B cell lines and T lymphocytes. Ref.2. Sequence similarities: Belongs to the selectin/LECAM family.Contains 1 C-type lectin domain.Contains 1 EGF-like domain.Contains 2 Sushi (CCP/SCR) domains. Sequence caution: The sequence CAA34203.1 differs from that shown. Reason: Erroneous initiation. Translation N-terminally shortened.The sequence CAB43536.1 differs from that shown. Reason: Erroneous initiation. Translation N-terminally shortened.The sequence CAB43537.1 differs from that shown. Reason: Erroneous initiation. Translation N-terminally shortened.

size :

0.01 mg

price :

200 USD

more info or order :

MyBioSource product webpage