protein

Interleukin-2 (Western Blot Control)

MBS343068

0.01 mg

200 USD

Recombinant Protein

Interleukin-2 (Western Blot Control)

Interleukin-2 (Western Blot Control)

IL-2; Interleukin-2; IL-2; T-Cell Growth Factor; TCGF

interleukin-2; Interleukin-2; interleukin-2; aldesleukin; OTTHUMP00000164090; T cell growth factor; involved in regulation of T-cell clonal expansion; interleukin 2; T-cell growth factor

IL2

IL2; IL2; IL-2; TCGF; lymphokine

IL2_HUMAN

153

Single band on Western blot.

Liquid. Supplied in 1x Laemmli Buffer (25mM Tris-HCl pH6.8, 50mM DTT, 1% (w/v) SDS, 0.1% (w/v) Bromophenol Blue, 2.5% Glycerol).

Human Recombinant Protein

Interkeukin-2 is a pleiotropic cytokine produced primarily by mitogenic or antigen activated T lymphocytes. IL-2 plays a key role in T cell proliferation and promotes the proliferation, expansion and differentiation of a wide variety of antigen specific cells. Our recombinant Interleukin-2 comprises a 133 amino acid fragment (21-153) corresponding to the mature Interleukin-2 protein and is expressed in E. coli with an amino-terminal hexahistidine tag. This product is for research use only and is not intended for diagnostic or therapeutic use.

Fletcher, M. & Goldstein, A.L. (1987) Lymphokine Res. 6(1): 45- 57. Jelinek, D.F. et al., (1986) Eur. J. Immunol. 16(8): 925- 932.

512412

CAA01199.1

P60568

17,628 Da

Allograft Rejection Pathway 83123!!Allograft Rejection Pathway 535!!Autoimmune Thyroid Disease Pathway 83121!!Autoimmune Thyroid Disease Pathway 533!!Calcineurin-regulated NFAT-dependent Transcription In Lymphocytes Pathway 137993!!Calcium Signaling In The CD4+ TCR Pathway 137941!!Chagas Disease (American Trypanosomiasis) Pathway 147809!!Chagas Disease (American Trypanosomiasis) Pathway 147795!!Cytokine Signaling In Immune System Pathway 366171!!Cytokine-cytokine Receptor Interaction Pathway 83051

The protein encoded by this gene is a secreted cytokine that is important for the proliferation of T and B lymphocytes. The receptor of this cytokine is a heterotrimeric protein complex whose gamma chain is also shared by interleukin 4 (IL4) and interleukin 7 (IL7). The expression of this gene in mature thymocytes is monoallelic, which represents an unusual regulatory mode for controlling the precise expression of a single gene. The targeted disruption of a similar gene in mice leads to ulcerative colitis-like disease, which suggests an essential role of this gene in the immune response to antigenic stimuli. [provided by RefSeq]

Function: Produced by T-cells in response to antigenic or mitogenic stimulation, this protein is required for T-cell proliferation and other activities crucial to regulation of the immune response. Can stimulate B-cells, monocytes, lymphokine-activated killer cells, natural killer cells, and glioma cells. Subcellular location: Secreted. Involvement in disease: Note=A chromosomal aberration involving IL2 is found in a form of T-cell acute lymphoblastic leukemia (T-ALL). Translocation t(4;16)(q26;p13) with involves TNFRSF17. Pharmaceutical use: Available under the name Proleukin (Chiron). Used in patients with renal cell carcinoma or metastatic melanoma. Sequence similarities: Belongs to the IL-2 family. Sequence caution: The sequence AAA59140.1 differs from that shown. Reason: Erroneous initiation.

0.01 mg

200 USD