MyBioSource

protein

Interleukin-13

MBS343061

0.01 mg

200 USD

MBS343061

Recombinant Protein

Interleukin-13

Interleukin-13

IL-13; Interleukin-13; IL-13; ALRH, P600

interleukin-13; Interleukin-13; interleukin-13; allergic rhinitis; OTTHUMP00000066048; Bronchial hyperresponsiveness-1 (bronchial asthma); interleukin 13; N/A

IL13

IL13; IL13; ALRH; BHR1; P600; IL-13; MGC116786; MGC116788; MGC116789; NC30

IL13_HUMAN

146

>95%.

Liquid

Total Volume: 715ul. Total Protein: 100ug

Store at -20 degree C

Buffer: 25mM Na Acetate pH 4.8, 1mM EDTA, 50% Glycerol.

Human Recombinant Protein

Interleukin-13 is a pleiotropic regulatory cytokine, which shares many of the properties of Interleukin-4. IL-13 is produced primarily by activated T lymphocytes and acts via specific cell surface receptor complexes. Its biological activities include the stimulation of B-cell proliferation and differentiation and the regulation of inflammatory and immune responses. Our recombinant Interleukin-13 comprises a 112 amino acid fragment (21-132) corresponding to the mature Interleukin-13 110R form of the protein and is expressed in E. coli with an amino-terminal hexahistidine tag. This product is for research use only and is not intended for diagnostic or therapeutic use.

Zurawski, G. & de Vries, J.E. (1994) Immunology Today 15(1) : 19-26.

26787978

NP_002179.2

NM_002188.2

P35225

16.84 kDa

Asthma Pathway 83120!!Asthma Pathway 532!!Cytokine-cytokine Receptor Interaction Pathway 83051!!Cytokine-cytokine Receptor Interaction Pathway 460!!Cytokines And Inflammatory Response Pathway 198794!!Fc Epsilon RI Signaling Pathway 83082!!Fc Epsilon RI Signaling Pathway 493!!Glucocorticoid Receptor Regulatory Network Pathway 138014!!IL12 Signaling Mediated By STAT4 Pathway 137936!!Jak-STAT Signaling Pathway 83077

This gene encodes an immunoregulatory cytokine produced primarily by activated Th2 cells. This cytokine is involved in several stages of B-cell maturation and differentiation. It up-regulates CD23 and MHC class II expression, and promotes IgE isotype switching of B cells. This cytokine down-regulates macrophage activity, thereby inhibits the production of pro-inflammatory cytokines and chemokines. This cytokine is found to be critical to the pathogenesis of allergen-induced asthma but operates through mechanisms independent of IgE and eosinophils. This gene, IL3, IL5, IL4, and CSF2 form a cytokine gene cluster on chromosome 5q, with this gene particularly close to IL4. [provided by RefSeq]

Function: Cytokine. Inhibits inflammatory cytokine production. Synergizes with IL2 in regulating interferon-gamma synthesis. May be critical in regulating inflammatory and immune responses. Subunit structure: Interacts with IL13RA2. Subcellular location: Secreted. Involvement in disease: Defects in IL13 may be a cause of susceptibility to allergic rhinitis (ALRH) [. MIM:607154]. Allergic rhinitis is a common disease of complex inheritance and is characterized by mucosal inflammation caused by allergen exposure. Sequence similarities: Belongs to the IL-4/IL-13 family. Caution: It is uncertain whether Met-1 or Met-15 is the initiator. Sequence caution: The sequence AAA36107.1 differs from that shown. Reason: Erroneous initiation. Translation N-terminally extended.The sequence AAA83738.1 differs from that shown. Reason: Erroneous initiation. Translation N-terminally extended.The sequence AAB01681.1 differs from that shown. Reason: Erroneous initiation. Translation N-terminally extended.The sequence AAC03535.1 differs from that shown. Reason: Erroneous initiation. Translation N-terminally extended.The sequence AAK53823.1 differs from that shown. Reason: Erroneous initiation. Translation N-terminally extended.The sequence CAA48824.1 differs from that shown. Reason: Erroneous initiation. Translation N-terminally extended.

0.01 mg

200 USD