Interferon Gamma (IFNg) (Western Blot Control) | MyBioSource MBS343051 product information

product summary

company name :

MyBioSource

product type :

protein

product name :

Interferon Gamma (IFNg) (Western Blot Control)

catalog :

MBS343051

quantity :

0.01 mg

price :

215 USD

more info or order :

MyBioSource product webpage

product information

catalog number :

MBS343051

products type :

Recombinant Protein

products full name :

Interferon Gamma (IFNg) (Western Blot Control)

products short name :

Interferon Gamma (IFNg)

products name syn :

Immune Interferon, type II interferon, T cell interferon, MAF, IFNG, IFG, IFI, IFN-gamma.

other names :

interferon-gamma; Interferon gamma; interferon gamma; interferon gamma; Immune interferon

products gene name :

IFNg

other gene names :

IFNG; IFNG; IFG; IFI; IFN-gamma

uniprot entry name :

IFNG_HUMAN

sequence length :

166

purity :

>= 95% (SDS PAGE)

form :

Liquid

other info2 :

Buffer: Buffered 50% glycerol

products categories :

Recombinant Proteins; Interferon Gamma

products description :

IFN gamma is a potent multifunctional cytokine primarily produced by T cells and natural killer cells. IFN gamma exerts a variety of antiproliferative, immunoregulatory and pro-inflammatory biological activities in response to binding at specific cell surface receptors. Recombinant IFN gamma comprises a 143 amino acid fragment (24-166) corresponding to the mature soluble IFN gamma chain protein and is expressed in E Coli with an amino-terminal hexahistidine tag. This product is not intended for therapeutic use.

products references :

Schreiber, R.D. & Farrar, M.A. (1993) Gastroenterol. J. 28(4): 88- 94.

ncbi gi num :

184639

ncbi acc num :

AAB59534.1

uniprot acc num :

P01579

ncbi mol weight :

19,348 Da

ncbi pathways :

ATF-2 Transcription Factor Network Pathway (138006); African Trypanosomiasis Pathway (194384); African Trypanosomiasis Pathway (194323); Allograft Rejection Pathway (920963); Allograft Rejection Pathway (83123); Allograft Rejection Pathway (535); Amoebiasis Pathway (167324); Amoebiasis Pathway (167191); Antigen Processing And Presentation Pathway (83074); Antigen Processing And Presentation Pathway (485)

ncbi summary :

This gene encodes a soluble cytokine that is a member of the type II interferon class. The encoded protein is secreted by cells of both the innate and adaptive immune systems. The active protein is a homodimer that binds to the interferon gamma receptor which triggers a cellular response to viral and microbial infections. Mutations in this gene are associated with an increased susceptibility to viral, bacterial and parasitic infections and to several autoimmune diseases. [provided by RefSeq, Dec 2015]

uniprot summary :

IFNG: Produced by lymphocytes activated by specific antigens or mitogens. IFN-gamma, in addition to having antiviral activity, has important immunoregulatory functions. It is a potent activator of macrophages, it has antiproliferative effects on transformed cells and it can potentiate the antiviral and antitumor effects of the type I interferons. Homodimer. Released primarily from activated T lymphocytes. Belongs to the type II (or gamma) interferon family. Protein type: Membrane protein, integral; Cytokine; Secreted, signal peptide; Secreted. Chromosomal Location of Human Ortholog: 12q14. Cellular Component: extracellular region; extracellular space. Molecular Function: cytokine activity. Biological Process: adaptive immune response; apoptosis; cell cycle arrest; cell motility; cell surface receptor linked signal transduction; humoral immune response; negative regulation of epithelial cell differentiation; negative regulation of interleukin-17 production; negative regulation of smooth muscle cell proliferation; negative regulation of transcription from RNA polymerase II promoter; positive regulation of autophagy; positive regulation of CD4-positive, CD25-positive, alpha-beta regulatory T cell differentiation during immune response; positive regulation of cell proliferation; positive regulation of interleukin-12 production; positive regulation of interleukin-23 production; positive regulation of killing of cells of another organism; positive regulation of membrane protein ectodomain proteolysis; positive regulation of nitric oxide biosynthetic process; positive regulation of osteoclast differentiation; positive regulation of peptidyl-serine phosphorylation of STAT protein; positive regulation of tyrosine phosphorylation of Stat1 protein; protein import into nucleus, translocation; regulation of insulin secretion; response to virus. Disease: Aplastic Anemia; Hepatitis C Virus, Susceptibility To; Human Immunodeficiency Virus Type 1, Susceptibility To; Mycobacterium Tuberculosis, Susceptibility To; Tuberous Sclerosis 2

size1 :

0.01 mg

price1 :

215 USD

more info or order :

MyBioSource product webpage