product summary
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company name :
MyBioSource
product type :
protein
product name :
Haptoglobin B-Chain
catalog :
MBS343039
quantity :
0.01 mg
price :
220 USD
more info or order :
MyBioSource product webpage
product information
catalog number :
MBS343039
products type :
Recombinant Protein
products full name :
Haptoglobin B-Chain
products short name :
Haptoglobin B-Chain
products name syn :
Hp, Bp; Haptoglobin beta-Chain
other names :
haptoglobin; Haptoglobin; Zonulin
other gene names :
HP
uniprot entry name :
HPT_HUMAN
sequence length :
406
purity :
>95% by SDS-PAGE
form :
Liquid
other info2 :
Buffer: Buffered 50% glycerol
products categories :
Recombinant Proteins; Haptoglobin beta-Chain
products description :
Haptoglobin is a glycoprotein secreted in the blood plasma that binds free haemoglobin thereby inhibiting its oxidative activity and preventing iron loss following haemolysis. Haptoglobin also regulates the activity of many cell types of the immune system and is an extracellular chaperone. Haptoglobin is produced mostly by hepatocytes but also by other tissues: e.g. skin, lung and kidney. Haptoglobin is a tetramer of two alpha - and two beta-chains, connected by disulfide bridges. The chains originate from a common precursor protein, which is proteolytically cleaved during protein synthesis. Recombinant Haptoglobin beta -chain comprises a 245 amino acid fragment (162-406) corresponding to the mature haptoglobin beta -chain and is expressed in E Coli with an amino-terminal hexahistidine tag. This product is not intended for therapeutic use.
products references :
Yang, F. et al., Proc. Natl. Acad. Sci. USA 80 (19):5875-5879 (1983). Kurosky, A. et al., Proc. Natl. Acad. Sci. USA 77 (6): 3388-3392 (1980).
ncbi gi num :
386783
ncbi acc num :
AAA88080.1
ncbi mol weight :
38,452 Da
uniprot summary :
HP: Haptoglobin combines with free plasma hemoglobin, preventing loss of iron through the kidneys and protecting the kidneys from damage by hemoglobin, while making the hemoglobin accessible to degradative enzymes. Defects in HP are the cause of anhaptoglobinemia (AHP). AHP is a condition characterized by the absence of the serum glycoprotein haptoglobin. Serum levels of haptoglobin vary among normal persons: levels are low in the neonatal period and in the elderly, differ by population, and can be influenced by environmental factors, such as infection. Secondary hypohaptoglobinemia can occur as a consequence of hemolysis, during which haptoglobin binds to free hemoglobin. Belongs to the peptidase S1 family. Protein type: Secreted, signal peptide; Secreted; Endoplasmic reticulum. Chromosomal Location of Human Ortholog: 16q22.2. Cellular Component: extracellular region; extracellular space. Molecular Function: hemoglobin binding; protein binding. Biological Process: defense response; negative regulation of oxidoreductase activity; receptor-mediated endocytosis; response to hydrogen peroxide. Disease: Anhaptoglobinemia
size1 :
0.01 mg
price1 :
220 USD
size2 :
0.1 mg
price2 :
555
size3 :
1 mg
price3 :
2535
more info or order :
MyBioSource product webpage
company information
MyBioSource
P.O. Box 153308
San Diego, CA 92195-3308
sales@mybiosource.com
https://www.mybiosource.com
1-888-627-0165
headquarters: USA
MyBioSource, LLC was orginally founded in Vancouver by three enthusiastic scientists who are passionate about providing the world with the best reagents available. Together, they form a company with a big vision known as MyBioSource. MyBioSource is now located in San Diego, California, USA.

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