product summary
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company name :
MyBioSource
product type :
protein
product name :
Glutathione S-Transferase Omega 1 140 D
catalog :
MBS343033
quantity :
0.01 mg
price :
190 USD
more info or order :
MyBioSource product webpage
product information
catalog number :
MBS343033
products type :
Recombinant Protein
products full name :
Glutathione S-Transferase Omega 1 140 D
products short name :
Glutathione S-Transferase Omega 1 140 D
products name syn :
GSTO1 140 D; Glutathione S-transferase omega 1 (GSTO1 140 D); Glutathione S-Transferase Omega 1; GSTTLp28; P28, glutathione S-transferase omega 1-1; glutathione transferase omega; glutathione transferase omega 1; glutathione-S-transferase like, Monomethyl
other names :
glutathione S-transferase omega; Glutathione S-transferase omega-1; glutathione S-transferase omega-1; GSTO-1; glutathione-dependent dehydroascorbate reductase; Glutathione-dependent dehydroascorbate reductase
products gene name :
GSTO1 140 D
other gene names :
GSTO1; GSTO1
uniprot entry name :
GSTO1_PIG
sequence length :
241
purity :
>95% by SDS-PAGE
form :
Liquid
products categories :
Human Recombinant Protein
products description :
GSTO1 is a member of the theta class glutathione S-transferase-like (GSTTL) protein family. GSTO1 is expressed in a wide range of human tissues and exhibits glutathione-dependent thiol transferase and dehydroascorbate reductase activities and also catalyzes the reduction of monomethylarsonate, an intermediate in the pathway of arsenic biotransformation. GSTO1 protects from oxidative stress, a risk factor for Alzheimer disease, vascular dementia and stroke. Several polymorphisms in the coding regions of the human GSTO1 have been identified. A polymorphism causing an alanine-to-aspartate (A140D) substitution in amino acid 140 produces a variant with lowered enzyme activities in the arsenic biotransformation. Our recombinant GSTO1 140D comprises a 241 amino acid fragment (1-241) corresponding to the GSTO1 140D mutant mature protein, which is expressed in E. coli with an amino-terminal hexahistidine tag. This product is for research use only and is not intended for diagnostic or therapeutic use.
products references :
Withbread, A. K. et al., Methods in Enzymology 2005; 401: 78-99 Kolsch, H. et al., Neurology 2004; 63 : 2255-2260.
ncbi gi num :
12249197
ncbi acc num :
AAF71994.2
uniprot acc num :
Q9N1F5
ncbi mol weight :
27,419 Da
ncbi pathways :
Biological Oxidations Pathway 370363!!Drug Metabolism - Cytochrome P450 Pathway 84449!!Drug Metabolism - Cytochrome P450 Pathway 427!!Glutathione Conjugation Pathway 370387!!Glutathione Metabolism Pathway 84401!!Glutathione Metabolism Pathway 343!!Metabolism Of Xenobiotics By Cytochrome P450 Pathway 84448!!Metabolism Of Xenobiotics By Cytochrome P450 Pathway 425!!Phase II Conjugation Pathway 370380
uniprot summary :
Function: Exhibits glutathione-dependent thiol transferase and dehydroascorbate reductase activities. Catalytic activity: RX + glutathione = HX + R-S-glutathione. Subunit structure: Homodimer. Ref.1. Subcellular location: Cytoplasm Ref.1. Tissue specificity: Most abundant in the liver and skeletal muscle; also expressed in heart, diaphragm, colon, thymus, kidney, lung, ovaries, spleen, intestine and pancreas. Ref.1. Sequence similarities: Belongs to the GST superfamily. Omega family.Contains 1 GST C-terminal domain.Contains 1 GST N-terminal domain. Mass spectrometry: Molecular mass is 27328 3 Da from positions 1 - 241. Determined by ESI. Ref.1
size :
0.01 mg
price :
190 USD
more info or order :
MyBioSource product webpage
company information
MyBioSource
P.O. Box 153308
San Diego, CA 92195-3308
sales@mybiosource.com
https://www.mybiosource.com
1-888-627-0165
headquarters: USA
MyBioSource, LLC was orginally founded in Vancouver by three enthusiastic scientists who are passionate about providing the world with the best reagents available. Together, they form a company with a big vision known as MyBioSource. MyBioSource is now located in San Diego, California, USA.

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