protein

C-Reactive Protein (Western Blot Control)

MBS343008

0.01 mg

150 USD

Recombinant Protein

C-Reactive Protein (Western Blot Control)

C-Reactive Protein (Western Blot Control)

CRP; C-Reactive Protein; CRP

C-reactive protein; C-reactive protein; C-reactive protein; pentraxin 1; OTTHUMP00000033307; C-reactive protein, pentraxin-related

CRP

CRP; CRP; PTX1; MGC88244; MGC149895; PTX1

CRP_HUMAN

Single band on Western blot.

Liquid. Supplied in 1x Laemmli Buffer (25mM Tris-HCl pH6.8, 50mM DTT, 1% (w/v) SDS, 0.1% (w/v) Bromophenol Blue, 2.5% Glycerol).

Human Recombinant Protein

Human C reactive protein (CRP) is a member of the pentraxin family of serum proteins and is composed of five identical non- covalently linked subunits. CRP is one of the major plasma proteins that increase in concentration during the acute phase response to tissue injury or inflammation. Increased serum levels of CRP have been associated with myocardial infarction, atherosclerosis and end-stage kidney disease. The amino acid sequence of ABC recombinant CRP is the same as the native form and is expressed in E. coli. This product is for research use only and is not intended for diagnostic or therapeutic use.

Woo, P et al., (1985) J. Biol. Chem. 260 (24): 13384- 13388. Pai, J.K. et al., (2004) N. Engl. J. Med. 351 (25): 2599- 2610.

30224

CAA39671.1

P02741

25,039 Da

Classical Antibody-mediated Complement Activation Pathway 106409!!Complement Cascade Pathway 106405!!Creation Of C4 And C2 Activators Pathway 106407!!IL6-mediated Signaling Events Pathway 137932!!Immune System Pathway 106386!!Initial Triggering Of Complement Pathway 106406!!Innate Immunity Signaling Pathway 106387!!Selenium Pathway 198825

The protein encoded by this gene belongs to the pentaxin family. It is involved in several host defense related functions based on its ability to recognize foreign pathogens and damaged cells of the host and to initiate their elimination by interacting with humoral and cellular effector systems in the blood. Consequently, the level of this protein in plasma increases greatly during acute phase response to tissue injury, infection, or other inflammatory stimuli. [provided by RefSeq]

Function: Displays several functions associated with host defense: it promotes agglutination, bacterial capsular swelling, phagocytosis and complement fixation through its calcium-dependent binding to phosphorylcholine. Can interact with DNA and histones and may scavenge nuclear material released from damaged circulating cells. Cofactor: Binds 2 calcium ions per subunit. Subunit structure: Homopentamer. Pentaxin (or pentraxin) have a discoid arrangement of 5 non-covalently bound subunits. Subcellular location: Secreted. Tissue specificity: Found in plasma. Induction: The concentration of CRP in plasma increases greatly during acute phase response to tissue injury, infection or other inflammatory stimuli. It is induced by IL1/interleukin-1 and IL6//interleukin-6. Miscellaneous: This protein owes its name to its ability precipitate pneumococcal C-polysaccharide in the presence of calcium. Sequence similarities: Belongs to the pentaxin family.Contains 1 pentaxin domain. Mass spectrometry: Molecular mass is 23028 Da from positions 19 - 224. Determined by MALDI. Ref.15Molecular mass is 22930 Da from positions 19 - 223. Determined by MALDI. Ref.15

0.01 mg

150 USD