Vascular Cell Adhesion Molecule 1 (VCAM-1) | MyBioSource MBS340504 product information

product summary

company name :

MyBioSource

product type :

antibody

product name :

Vascular Cell Adhesion Molecule 1 (VCAM-1)

catalog :

MBS340504

quantity :

1 mL

price :

465 USD

clonality :

polyclonal

host :

sheep

conjugate :

nonconjugated

reactivity :

human

application :

western blot, ELISA, immunohistochemistry, enzyme immunoassay

more info or order :

MyBioSource product webpage

product information

catalog number :

MBS340504

products type :

Antibody

products full name :

Vascular Cell Adhesion Molecule 1 (VCAM-1)

products short name :

Vascular Cell Adhesion Molecule 1 (VCAM-1)

products name syn :

Vascular cell adhesion protein 1; V-CAM1; INCAM-100; CD106 antigen; VCAM1; L1CAM

other names :

vascular cell adhesion molecule-1; Vascular cell adhesion protein 1; vascular cell adhesion protein 1; vascular cell adhesion molecule 1; INCAM-100; CD_antigen: CD106

products gene name :

VCAM-1

other gene names :

VCAM1; VCAM1; CD106; INCAM-100; L1CAM; V-CAM 1; VCAM-1

uniprot entry name :

VCAM1_HUMAN

clonality :

Polyclonal

host :

Sheep

sequence length :

739

form :

Ig Fraction - Liquid

concentration :

>5mg/ml (U.V.abs @ 280nm)

storage stability :

Upon delivery aliquot and store at -20 degree C. Avoid freeze / thaw cycles. Short term storage 2 - 8 degree C.

tested application :

ELISA (EIA), Western Blot (WB), Dot Blot (DB), Immunohistochemistry (IHC), Immunoassays, Development of Rapid tests and Other Immunoassay, Antibody Recognition Assays

other info1 :

Immunogen: Recombinant Human VCAM-1

other info2 :

Buffer: 20mM Phosphate, 150mM Sodium Chloride. Preservative: 0.09% Sodium Azide

products categories :

Polyclonal Antibodies; Biochemical Markers; Proteins; Vascular Cell Adhesion Molecule-1

products description :

VCAM-1 is a cell surface sialoglycoprotein expressed by cytokine activated endothelium. The protein has a number of functions including the regulation of leukocyte migration, leukocyte-endothelial cell adhesion and signal transduction and may play a role in a number of inflammatory diseases. Recombinant VCAM comprises a 674 amino acid fragment (25-698) corresponding to the mature extracellular VCAM protein and is expressed in E Coli with an amino-terminal hexahistidine tag. This product is for research use only and is not intended for diagnostic or therapeutic use.

products references :

Steeber, D. A & Tedder, T.F. (2000) Immuno. Res. 22(2- 3): 299- 317. Albelda, S.M et al. (1994) FASEB J. 8(8): 504-512

ncbi gi num :

340194

ncbi acc num :

AAA61269.1

uniprot acc num :

P19320

ncbi mol weight :

74,346 Da

ncbi pathways :

AGE-RAGE Signaling Pathway In Diabetic Complications (1319988); AGE-RAGE Signaling Pathway In Diabetic Complications (1319775); Adaptive Immune System Pathway (1269171); African Trypanosomiasis Pathway (194384); African Trypanosomiasis Pathway (194323); Cell Adhesion Molecules (CAMs) Pathway (83069); Cell Adhesion Molecules (CAMs) Pathway (480); Cellular Roles Of Anthrax Toxin Pathway (138076); Cytokine Signaling In Immune System Pathway (1269310); Extracellular Matrix Organization Pathway (1270244)

ncbi summary :

This gene is a member of the Ig superfamily and encodes a cell surface sialoglycoprotein expressed by cytokine-activated endothelium. This type I membrane protein mediates leukocyte-endothelial cell adhesion and signal transduction, and may play a role in the development of artherosclerosis and rheumatoid arthritis. Three alternatively spliced transcripts encoding different isoforms have been described for this gene. [provided by RefSeq, Dec 2010]

uniprot summary :

VCAM1: Important in cell-cell recognition. Appears to function in leukocyte-endothelial cell adhesion. Interacts with the beta-1 integrin VLA4 on leukocytes, and mediates both adhesion and signal transduction. The VCAM1/VLA4 interaction may play a pathophysiologic role both in immune responses and in leukocyte emigration to sites of inflammation. 2 isoforms of the human protein are produced by alternative splicing. Protein type: Cell adhesion; Motility/polarity/chemotaxis; Membrane protein, integral. Chromosomal Location of Human Ortholog: 1p32-p31. Cellular Component: apical part of cell; cell surface; early endosome; endoplasmic reticulum; external side of plasma membrane; extracellular space; filopodium; Golgi apparatus; microvillus; plasma membrane; podosome. Molecular Function: amine oxidase activity; cell adhesion molecule binding; integrin binding. Biological Process: amine metabolic process; B cell differentiation; cell adhesion; cell-matrix adhesion; extracellular matrix organization and biogenesis; heterophilic cell adhesion; leukocyte adhesion; leukocyte tethering or rolling; membrane to membrane docking; positive regulation of T cell proliferation; regulation of immune response

size1 :

1 mL

price1 :

465 USD

more info or order :

MyBioSource product webpage