antibody

Phenytoin

MBS340353

0.1 mL

600 USD

polyclonal

sheep

nonconjugated

western blot, ELISA, immunohistochemistry, enzyme immunoassay

Antibody

Phenytoin

Phenytoin

Phenytoin sodium; Phenytek; Dilantin; Dilantin Kapseals; Dilantin Infatabs; Eptoin Epanutin; Diphenin; Dipheninum

Polyclonal

Sheep

Ig Fraction - Liquid

>5mg/ml (U.V.abs @ 280nm)

Upon delivery aliquot and store at -20 degree C. Avoid freeze / thaw cycles. Short term storage 2 - 8 degree C.

ELISA (EIA), Western Blot (WB), Dot Blot (DB), Immunohistochemistry (IHC), Immunoassays, Development of Rapid tests and Other Immunoassay, Antibody Recognition Assays

Immunogen: Phenytoin-BTG

Buffer: 20mM Phosphate, 150mM Sodium Chloride. Preservative: 0.09% Sodium Azide

Polyclonal Antibodies; Drugs of Abuse; Therapeutic Drugs; Phenytoin

Phenytoin is an anticonvulsant that is used in a wide variety of seizures. It is also an anti-arrhythmic and a muscle relaxant. The mechanism of therapeutic action is not clear, although several cellular actions have been described including effects on ion channels, active transport, and general membrane stabilization. The mechanism of its muscle relaxant effect appears to involve a reduction in the sensitivity of muscle spindles to stretch. Phenytoin has been proposed for several other therapeutic uses, but its use has been limited by its many adverse effects and interactions with other drugs. Phenytoin is an antiepileptic drug which can be useful in the treatment of epilepsy. The primary site of action appears to be the motor cortex where spread of seizure activity is inhibited. Phenytoin reduces the maximal activity of brain stem centres responsible for the tonic phase of tonic-clonic (grand mal) seizures. Phenytoin acts to damp the unwanted, runaway brain activity seen in seizure by reducing electrical conductance among brain cells. It lacks the sedation effects associated with phenobarbital. There are some indications that phenytoin has other effects, including anxiety control and mood stabilization, although it has never been approved for those purposes by the FDA. Phenytoin acts on sodium channels on the neuronal cell membrane, limiting the spread of seizure activity and reducing seizure propagation. By promoting sodium efflux from neurons, phenytoin tends to stabilize the threshold against hyperexcitability caused by excessive stimulation or environmental changes capable of reducing membrane sodium gradient.

0.1 mL

600 USD

1 mL

2330