Neutrophil Gelatinase Associate Lipocalin (NGAL) | MyBioSource MBS340313 product information

product summary

company name :

MyBioSource

product type :

antibody

product name :

Neutrophil Gelatinase Associate Lipocalin (NGAL)

catalog :

MBS340313

quantity :

1 mL

price :

465 USD

clonality :

polyclonal

host :

sheep

conjugate :

nonconjugated

reactivity :

human

application :

western blot, ELISA, immunohistochemistry, enzyme immunoassay

more info or order :

MyBioSource product webpage

product information

catalog number :

MBS340313

products type :

Antibody

products full name :

Neutrophil Gelatinase Associate Lipocalin (NGAL)

products short name :

Neutrophil Gelatinase Associate Lipocalin (NGAL)

products name syn :

Neutrophil gelatinase-associated lipocalin;; 25; 25 kDa alpha-2-microglobulin-related subunit of MMP-9; Lipocalin-2; Oncogene 24p3

other names :

neutrophil gelatinase-associated lipocalin; Neutrophil gelatinase-associated lipocalin; neutrophil gelatinase-associated lipocalin; lipocalin 2; 25 kDa alpha-2-microglobulin-related subunit of MMP-9; Lipocalin-2; Oncogene 24p3; Siderocalin LCN2; p25

products gene name :

NGAL

other gene names :

LCN2; LCN2; p25; 24p3; MSFI; NGAL; HNL; NGAL; NGAL

uniprot entry name :

NGAL_HUMAN

clonality :

Polyclonal

host :

Sheep

sequence length :

198

form :

Ig Fraction - Liquid

concentration :

>5mg/ml (U.V.abs @ 280nm)

storage stability :

Upon delivery aliquot and store at -20 degree C. Avoid freeze / thaw cycles. Short term storage 2 - 8 degree C.

tested application :

ELISA (EIA), Western Blot (WB), Dot Blot (DB), Immunohistochemistry (IHC), Immunoassays, Development of Rapid tests and Other Immunoassay, Antibody Recognition Assays

other info1 :

Immunogen: Recombinant Human NGAL

other info2 :

Buffer: 20mM Phosphate, 150mM Sodium Chloride. Preservative: 0.09% Sodium Azide

products categories :

Polyclonal Antibodies; Biochemical Markers; Proteins; Neutrophil Gelatinase Associated Lipocalin

products description :

The lipocalins are a family of around 25 proteins, which are characterized by their ability to bind small lipophilic substances in their hydrophobic core. They thereby serve as transporters of substances like retinal, biliverdins & prostaglandins. There are indications that NGAL is involved in modulation of the inflammatory response and is found in the plasma of patients after stroke. Recombinant human NGAL is expressed in E Coli with an amino-terminal hexahistidine tag. This product is for research use only and is not intended for diagnostic or therapeutic use.

products references :

Elneihoum, A.M. et al. (1996) Stroke 27(10): 1734-38.

ncbi gi num :

38455402

ncbi acc num :

NP_005555.2

ncbi gb acc num :

NM_005564.4

uniprot acc num :

P80188

ncbi mol weight :

22,457 Da

ncbi pathways :

Iron Uptake And Transport Pathway (1269948); Transmembrane Transport Of Small Molecules Pathway (1269903)

ncbi summary :

This gene encodes a protein that belongs to the lipocalin family. Members of this family transport small hydrophobic molecules such as lipids, steroid hormones and retinoids. The protein encoded by this gene is a neutrophil gelatinase-associated lipocalin and plays a role in innate immunity by limiting bacterial growth as a result of sequestering iron-containing siderophores. The presence of this protein in blood and urine is an early biomarker of acute kidney injury. This protein is thought to be be involved in multiple cellular processes, including maintenance of skin homeostasis, and suppression of invasiveness and metastasis. Mice lacking this gene are more susceptible to bacterial infection than wild type mice. [provided by RefSeq, Sep 2015]

uniprot summary :

LCN2: Iron-trafficking protein involved in multiple processes such as apoptosis, innate immunity and renal development. Binds iron through association with 2,5-dihydroxybenzoic acid (2,5- DHBA), a siderophore that shares structural similarities with bacterial enterobactin, and delivers or removes iron from the cell, depending on the context. Iron-bound form (holo-24p3) is internalized following binding to the SLC22A17 (24p3R) receptor, leading to release of iron and subsequent increase of intracellular iron concentration. In contrast, association of the iron-free form (apo-24p3) with the SLC22A17 (24p3R) receptor is followed by association with an intracellular siderophore, iron chelation and iron transfer to the extracellular medium, thereby reducing intracellular iron concentration. Involved in apoptosis due to interleukin-3 (IL3) deprivation: iron-loaded form increases intracellular iron concentration without promoting apoptosis, while iron-free form decreases intracellular iron levels, inducing expression of the proapoptotic protein BCL2L11/BIM, resulting in apoptosis. Involved in innate immunity, possibly by sequestrating iron, leading to limit bacterial growth. Belongs to the calycin superfamily. Lipocalin family. 2 isoforms of the human protein are produced by alternative splicing. Protein type: Secreted, signal peptide; Secreted. Chromosomal Location of Human Ortholog: 9q34. Cellular Component: extracellular region; extracellular space. Molecular Function: iron ion binding. Biological Process: cellular iron ion homeostasis; innate immune response; siderophore transport

size1 :

1 mL

price1 :

465 USD

more info or order :

MyBioSource product webpage