antibody

Macrophage Inflammatory Protein-1 alpha

MBS340248

1 ml

350 USD

polyclonal

sheep

nonconjugated

Antibody

Macrophage Inflammatory Protein-1 alpha

Macrophage Inflammatory Protein-1 alpha

Anti - Macrophage Inflammatory, Protein-1a (MIP-1a); MACROPHAGE INFLAMMATORY PROTEIN 1 ALPHA

macrophage inflammatory protein 1 alpha; C-C motif chemokine 3; C-C motif chemokine 3; SIS-beta; PAT 464.1; OTTHUMP00000163953; G0/G1 switch regulatory protein 19-1; macrophage inflammatory protein 1-alpha; tonsillar lymphocyte LD78 alpha protein; small inducible cytokine A3 (homologous to mouse Mip-1a); chemokine (C-C motif) ligand 3; G0/G1 switch regulatory protein 19-1; Macrophage inflammatory protein 1-alpha; MIP-1-alpha; PAT 464.1; SIS-beta; Small-inducible cytokine A3; Tonsillar lymphocyte LD78 alpha proteinCleaved into the following chain:MIP-1-alpha(4-69); Alternative name(s):; LD78-alpha(4-69)

MIP-1a

CCL3; CCL3; MIP1A; SCYA3; G0S19-1; LD78ALPHA; MIP-1-alpha; G0S19-1; MIP1A; SCYA3

CCL3_HUMAN

Polyclonal

Sheep

92

Ig fraction, liquid

Store at -20 degree C. Avoid repeated freeze/thaw cycles.

Immunogen: Recombinant Human MIP-1a

Buffer: 20mM Phosphate, 150mM Sodium Chloride, pH 7.2. Preservative: 0.09% Sodium Azide

2905628

AAC03539.1

P10147

10,085 Da

Chagas Disease (American Trypanosomiasis) Pathway 147809!!Chagas Disease (American Trypanosomiasis) Pathway 147795!!Chemokine Receptors Bind Chemokines Pathway 106359!!Chemokine Signaling Pathway 99051!!Chemokine Signaling Pathway 96864!!Class A/1 (Rhodopsin-like Receptors) Pathway 106357!!Cytokine-cytokine Receptor Interaction Pathway 83051!!Cytokine-cytokine Receptor Interaction Pathway 460!!GPCR Ligand Binding Pathway 161020!!IL12-mediated Signaling Events Pathway 137922

This locus represents a small inducible cytokine. The encoded protein, also known as macrophage inflammatory protein 1 alpha, plays a role in inflammatory responses through binding to the receptors CCR1, CCR4 and CCR5. Polymorphisms at this locus may be associated with both resistance and susceptibility to infection by human immunodeficiency virus type 1.

Function: Monokine with inflammatory and chemokinetic properties. Binds to CCR1, CCR4 and CCR5. One of the major HIV-suppressive factors produced by CD8+ T-cells. Recombinant MIP-1-alpha induces a dose-dependent inhibition of different strains of HIV-1, HIV-2, and simian immunodeficiency virus (SIV). Ref.8. Subunit structure: Self-associates. Also heterodimer of MIP-1-alpha(4-69) and MIP-1-beta(3-69). Ref.11. Subcellular location: Secreted. Induction: By TPA or PHA (TPA = 12-O-tetradecanoyl phorbol-13 acetate (tumor promoter); PHA = phytohemagglutinin (T-cell mitogen)). Post-translational modification: N-terminal processed form LD78-alpha(4-69) is produced by proteolytic cleavage after secretion from HTLV1-transformed T-cells. Sequence similarities: Belongs to the intercrine beta (chemokine CC) family.

1 ml

350 USD