catalog number :
MBS335334
products full name :
Mouse Anti-Human CD109 Monoclonal Antibody, Azide Free Clone B-E47
products short name :
CD109
products name syn :
CD109
other names :
CD109 antigen isoform 3 preproprotein; CD109 antigen; CD109 antigen; CD109 molecule; 150 kDa TGF-beta-1-binding protein; C3 and PZP-like alpha-2-macroglobulin domain-containing protein 7; Platelet-specific Gov antigen; p180; r150; CD_antigen: CD109
products gene name :
CD109
other gene names :
CD109; CD109; p180; r150; CPAMD7; CPAMD7
uniprot entry name :
CD109_HUMAN
specificity :
Recognises a 170 kDa protein
purity :
Ion exchange chromatography
form :
Azide free. Phosphate-buffered saline. Sterile-filtered through 0.22 um. Carrier and preservative free
concentration :
Quantity: 200ug/ 200ul
storage stability :
Store at +2-8 degree C for 12 months. For longer storage, freeze aliquots.
tested application :
Flow Cytometry (FC/FACS)
other info2 :
Antigen: CD109. Hybridoma: Myeloma X63/AG.8653 x Balb/c spleen cells. Immunisation: Eahy 926 cell line
ncbi acc num :
NP_001153060.1
ncbi gb acc num :
NM_001159588.2
ncbi mol weight :
159,696 Da
ncbi summary :
This gene encodes a glycosyl phosphatidylinositol (GPI)-linked glycoprotein that localizes to the surface of platelets, activated T-cells, and endothelial cells. The protein binds to and negatively regulates signalling by transforming growth factor beta (TGF-beta). Multiple transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Apr 2014]
uniprot summary :
CD109: Modulates negatively TGFB1 signaling in keratinocytes. Belongs to the protease inhibitor I39 (alpha-2- macroglobulin) family. 4 isoforms of the human protein are produced by alternative splicing. Protein type: Membrane protein, GPI anchor. Chromosomal Location of Human Ortholog: 6q13. Cellular Component: extracellular space; cell surface; plasma membrane. Molecular Function: serine-type endopeptidase inhibitor activity; transforming growth factor beta binding. Biological Process: negative regulation of protein amino acid phosphorylation; hair follicle development; negative regulation of transforming growth factor beta receptor signaling pathway; regulation of keratinocyte differentiation