product summary
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company name :
MyBioSource
product type :
antibody
product name :
Mouse Anti-Human MICB Monoclonal Antibody, Azide Free Clone B-D55
catalog :
MBS335251
quantity :
0.2 mg
price :
300 USD
clonality :
monoclonal
host :
mouse
conjugate :
nonconjugated
clone name :
B-D55
reactivity :
human
application :
ELISA, enzyme immunoassay
more info or order :
MyBioSource product webpage
product information
catalog number :
MBS335251
products type :
Antibody
products full name :
Mouse Anti-Human MICB Monoclonal Antibody, Azide Free Clone B-D55
products short name :
MICB
products name syn :
MICB
other names :
MICB, partial; MHC class I polypeptide-related sequence B; MHC class I polypeptide-related sequence B; MHC class I polypeptide-related sequence B
products gene name :
MICB
other gene names :
MICB; MICB; PERB11.2; MIC-B
uniprot entry name :
MICB_HUMAN
clonality :
Monoclonal
isotype :
IgG1
clone :
B-D55
host :
Mouse
reactivity :
Human
sequence length :
305
specificity :
Recognises both natural and recombinant human MICB
purity :
Ion exchange chromatography
form :
Azide free. Phosphate-buffered saline. Sterile-filtered through 0.22 um. Carrier and preservative free
storage stability :
Stable at +2-8 degree C for 12 months. For longer storage, freeze aliquots.
tested application :
ELISA (EIA)
app notes :
Recognises soluble antigen
other info2 :
Antigen: MICB. Hybridoma: Myeloma X63/AG.8653 x Balb/c node cells. Immunisation: Recombinant human MICB
ncbi gi num :
4521252
ncbi acc num :
BAA23485.1
uniprot acc num :
Q29980
ncbi mol weight :
4,287 Da
ncbi pathways :
Adaptive Immune System Pathway (1269171); Immune System Pathway (1269170); Immunoregulatory Interactions Between A Lymphoid And A Non-Lymphoid Cell Pathway (1269201); Natural Killer Cell Mediated Cytotoxicity Pathway (83079); Natural Killer Cell Mediated Cytotoxicity Pathway (490)
ncbi summary :
This gene encodes a heavily glycosylated protein which is a ligand for the NKG2D type II receptor. Binding of the ligand activates the cytolytic response of natural killer (NK) cells, CD8 alphabeta T cells, and gammadelta T cells which express the receptor. This protein is stress-induced and is similar to MHC class I molecules; however, it does not associate with beta-2-microglobulin or bind peptides. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Jan 2014]
uniprot summary :
MICB: Seems to have no role in antigen presentation. Acts as a stress-induced self-antigen that is recognized by gamma delta T cells. Ligand for the KLRK1/NKG2D receptor. Binding to KLRK1 leads to cell lysis. Genetic variations in MICA are a cause of susceptibility to rheumatoid arthritis (RA). It is a systemic inflammatory disease with autoimmune features and a complex genetic component. It primarily affects the joints and is characterized by inflammatory changes in the synovial membranes and articular structures, widespread fibrinoid degeneration of the collagen fibers in mesenchymal tissues, and by atrophy and rarefaction of bony structures. The MICB*004 allele is associated with rheumatoid arthritis. Genetic variation in MICB is associated with cytomegalovirus and herpes simplex virus I seropositivity and this may be associated with schizophrenia risk. Belongs to the MHC class I family. MIC subfamily. 3 isoforms of the human protein are produced by alternative splicing. Protein type: Membrane protein, integral. Chromosomal Location of Human Ortholog: 6p21.3. Cellular Component: cell surface; integral to membrane; plasma membrane. Molecular Function: beta-2-microglobulin binding; antigen binding; natural killer cell lectin-like receptor binding. Biological Process: antigen processing and presentation; regulation of immune response; response to retinoic acid; viral reproduction; natural killer cell mediated cytotoxicity; response to heat; cytolysis; immune response-activating cell surface receptor signaling pathway; response to oxidative stress; negative regulation of defense response to virus by host; gamma-delta T cell activation; T cell mediated cytotoxicity
size1 :
0.2 mg
price1 :
300 USD
more info or order :
MyBioSource product webpage
company information
MyBioSource
P.O. Box 153308
San Diego, CA 92195-3308
sales@mybiosource.com
https://www.mybiosource.com
1-888-627-0165
headquarters: USA
MyBioSource, LLC was orginally founded in Vancouver by three enthusiastic scientists who are passionate about providing the world with the best reagents available. Together, they form a company with a big vision known as MyBioSource. MyBioSource is now located in San Diego, California, USA.

"MyBioSource's number 1 vision is to be the world's number 1 quality reagents provider."

Our goal is to provide researchers, scientists and customers alike with a one-stop-shop for all of their reagents needs, whether it is monoclonal antibody, polyclonal antibody, recombinant protein, peptide, etc...

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