catalog number :
MBS335058
products full name :
Mouse Anti-Human Galectin-3 Monoclonal Antibody, Azide Free Clone B-E53
products short name :
Galectin-3
products name syn :
Galectin-3
other names :
galectin-3; Galectin-3; galectin-3; lectin, galactoside-binding, soluble, 3; 35 kDa lectin; Carbohydrate-binding protein 35; CBP 35; Galactose-specific lectin 3; Galactoside-binding protein; GALBP; IgE-binding protein; L-31; Laminin-binding protein; Lectin L-29; Mac-2 antigen
other gene names :
LGALS3; LGALS3; L31; GAL3; MAC2; CBP35; GALBP; GALIG; LGALS2; MAC2; Gal-3; CBP 35; GALBP
uniprot entry name :
LEG3_HUMAN
specificity :
Recognises both natural and recombinant protein
purity :
Ion exchange chromatography
form :
Azide free. Phosphate-buffered saline. Sterile-filtered through 0.22 um. Carrier and preservative free
storage stability :
Stable at +2-8 degree C for 12 months. For longer storage, freeze aliquots.
tested application :
ELISA (EIA)
app notes :
Recognises soluble antigen
other info2 :
Antigen: Galectin-9/ Ecalectin / HUAT / LGALS9. Hybridoma: Myeloma X63/AG8. x Balb/c node cells. Immunisation: Recombinant human Galectin-3
ncbi acc num :
BAA22164.1
ncbi mol weight :
26,152 Da
ncbi pathways :
AGE/RAGE Pathway (698754); Advanced Glycosylation Endproduct Receptor Signaling Pathway (1269258); Hedgehog Signaling Events Mediated By Gli Proteins Pathway (137912); Immune System Pathway (1269170); Innate Immune System Pathway (1269203); Spinal Cord Injury Pathway (739007)
ncbi summary :
This gene encodes a member of the galectin family of carbohydrate binding proteins. Members of this protein family have an affinity for beta-galactosides. The encoded protein is characterized by an N-terminal proline-rich tandem repeat domain and a single C-terminal carbohydrate recognition domain. This protein can self-associate through the N-terminal domain allowing it to bind to multivalent saccharide ligands. This protein localizes to the extracellular matrix, the cytoplasm and the nucleus. This protein plays a role in numerous cellular functions including apoptosis, innate immunity, cell adhesion and T-cell regulation. The protein exhibits antimicrobial activity against bacteria and fungi. Alternate splicing results in multiple transcript variants.[provided by RefSeq, Oct 2014]
uniprot summary :
Galectin-3: galactose-specific lectin which binds IgE. Expressed at a high level in the colonic epithelium. Also abundant in activated macrophages. Protein type: Cell surface; Motility/polarity/chemotaxis; Extracellular matrix. Chromosomal Location of Human Ortholog: 14q22.3. Cellular Component: spliceosome; extracellular matrix; proteinaceous extracellular matrix; extracellular space; membrane; mitochondrial inner membrane; cytoplasm; plasma membrane; immunological synapse; nucleus; external side of plasma membrane. Molecular Function: protein binding; laminin binding; IgE binding; carbohydrate binding; chemoattractant activity. Biological Process: neutrophil chemotaxis; extracellular matrix organization and biogenesis; negative regulation of endocytosis; RNA splicing; regulation of T cell proliferation; negative regulation of T cell receptor signaling pathway; macrophage chemotaxis; monocyte chemotaxis; epithelial cell differentiation; positive chemotaxis; eosinophil chemotaxis; innate immune response; mRNA processing; skeletal development