protein

Ferritin Light Chain Recomb.

MBS319818

1 mg

200 USD

Recombinant Protein

Ferritin Light Chain Recomb.

[Ferritin Light Chain]

[ferritin light chain; Ferritin light chain; ferritin light chain; ferritin, light polypeptide]

[FTL; FTL; LFTD; NBIA3; Ferritin L subunit]

FRIL_HUMAN

E Coli

175

> 95% pure (PAGE). Heat treatment purification.

Purified, Liquid

5.26 mg/mL Centaur Ferritin Assay

Store at 2-8 degree C. For long term, aliquot and store at -20 degree C to avoid multiple/freeze thaw cycles.

ELISA (EIA)

Buffer: Phosphate Buffered Saline, pH 7.4 0.2. Preservative: None

Important Note: Centrifuge before opening to ensure complete recovery of vial contents

Purified Proteins and Bioactive Peptides

Ferritin Light Chain Recomb. Ferritin Light Chain Recombinant. NCBI reference number: NM 000146.3. 185 a.a. in length. There is no fusion tag included in this product. Centaur Ferritin/Vitamin B12 Ratio - > 5,260,000. Cobas Ferritin/Vitamin B12 Ratio - 4,500,000. Cobas CEA Assay - Lot Specific. Centaur CEA Assay - Lot Specific. Cobas Ferritin Assay - Lot Specific. Cobas B12 Assay - Lot Specific

20149498

NP_000137.2

NM_000146.3

Binding And Uptake Of Ligands By Scavenger Receptors Pathway (1269897); Clathrin Derived Vesicle Budding Pathway (1269881); Golgi Associated Vesicle Biogenesis Pathway (1269882); Integrated Pancreatic Cancer Pathway (711360); Iron Uptake And Transport Pathway (1269948); Membrane Trafficking Pathway (1269877); Mineral Absorption Pathway (212237); Mineral Absorption Pathway (212220); Scavenging By Class A Receptors Pathway (1269899); Transmembrane Transport Of Small Molecules Pathway (1269903)

This gene encodes the light subunit of the ferritin protein. Ferritin is the major intracellular iron storage protein in prokaryotes and eukaryotes. It is composed of 24 subunits of the heavy and light ferritin chains. Variation in ferritin subunit composition may affect the rates of iron uptake and release in different tissues. A major function of ferritin is the storage of iron in a soluble and nontoxic state. Defects in this light chain ferritin gene are associated with several neurodegenerative diseases and hyperferritinemia-cataract syndrome. This gene has multiple pseudogenes. [provided by RefSeq, Jul 2008]

FTL: Stores iron in a soluble, non-toxic, readily available form. Important for iron homeostasis. Iron is taken up in the ferrous form and deposited as ferric hydroxides after oxidation. Also plays a role in delivery of iron to cells. Mediates iron uptake in capsule cells of the developing kidney. Defects in FTL are the cause of hereditary hyperferritinemia-cataract syndrome (HHCS). It is an autosomal dominant disease characterized by early-onset bilateral cataract. Affected patients have elevated level of circulating ferritin. HHCS is caused by mutations in the iron responsive element (IRE) of the FTL gene. Defects in FTL are the cause of neurodegeneration with brain iron accumulation type 3 (NBIA3); also known as adult-onset basal ganglia disease. It is a movement disorder with heterogeneous presentations starting in the fourth to sixth decade. It is characterized by a variety of neurological signs including parkinsonism, ataxia, corticospinal signs, mild nonprogressive cognitive deficit and episodic psychosis. It is linked with decreased serum ferritin levels. Belongs to the ferritin family. Protein type: Oxidoreductase. Chromosomal Location of Human Ortholog: 19q13.33. Cellular Component: cytosol; ferritin complex; membrane. Molecular Function: ferric iron binding; identical protein binding; iron ion binding; protein binding. Biological Process: cellular iron ion homeostasis; iron ion homeostasis; iron ion transport; post-Golgi vesicle-mediated transport; receptor-mediated endocytosis; transmembrane transport. Disease: Hyperferritinemia With Or Without Cataract; L-ferritin Deficiency; Neurodegeneration With Brain Iron Accumulation 3

1 mg

200 USD