antibody

Troponin I-cardiac (region 24-40)

MBS319676

1 mg

560 USD

monoclonal

mouse

nonconjugated

[B1614M]

western blot, ELISA, enzyme immunoassay

Antibody

Troponin I-cardiac (region 24-40)

[Troponin I-Cardiac]

[Monoclonal Antibody to Human Cardiac Troponin I (cTnI); MAb TO TROPONIN I-CARDIAC]

[troponin I, cardiac muscle; Troponin I, cardiac muscle; troponin I, cardiac muscle; cardiomyopathy, dilated 2A (autosomal recessive); troponin I type 3 (cardiac); Cardiac troponin I]

[TNNI3; TNNI3; CMH7; RCM1; cTnI; CMD2A; TNNC1; CMD1FF; TNNC1]

TNNI3_HUMAN

Monoclonal

IgG1

[B1614M]

Mouse

210

Human Cardiac Troponin I (cTnI) (24-40 region)

> 95% pure (HPLC). Protein A Chromatography. Purified

Liquid

3.7 mg/mL (OD280 E 0.1% =1.4)

Store at 2-8 degree C.

ELISA (EIA), Western Blot (WB)

Recombinant pairs for sandwich immunoassay: . Capture: MBS311155; Detection: MBS319676

Source: Ascites

Buffer: 20 mM Sodium Phosphate, 150 mM Sodium Chloride, pH 7.2. Immunogen: Proprietary.

Monoclonal Antibodies to Cardiac Markers

151101270

NP_000354.4

NM_000363.4

24,008 Da

Adrenergic Signaling In Cardiomyocytes Pathway (908257); Adrenergic Signaling In Cardiomyocytes Pathway (909696); Cardiac Progenitor Differentiation Pathway (712094); Cardiac Muscle Contraction Pathway (93344); Cardiac Muscle Contraction Pathway (93992); Dilated Cardiomyopathy Pathway (121494); Dilated Cardiomyopathy Pathway (121285); Hypertrophic Cardiomyopathy (HCM) Pathway (114229); Hypertrophic Cardiomyopathy (HCM) Pathway (106591); Muscle Contraction Pathway (106261)

Troponin I (TnI), along with troponin T (TnT) and troponin C (TnC), is one of 3 subunits that form the troponin complex of the thin filaments of striated muscle. TnI is the inhibitory subunit; blocking actin-myosin interactions and thereby mediating striated muscle relaxation. The TnI subfamily contains three genes: TnI-skeletal-fast-twitch, TnI-skeletal-slow-twitch, and TnI-cardiac. This gene encodes the TnI-cardiac protein and is exclusively expressed in cardiac muscle tissues. Mutations in this gene cause familial hypertrophic cardiomyopathy type 7 (CMH7) and familial restrictive cardiomyopathy (RCM). [provided by RefSeq, Jul 2008]

TNNI3: Troponin I is the inhibitory subunit of troponin, the thin filament regulatory complex which confers calcium-sensitivity to striated muscle actomyosin ATPase activity. Binds to actin and tropomyosin. Interacts with TRIM63. Interacts with STK4/MST1. Belongs to the troponin I family. Protein type: Motor; Actin-binding; Motility/polarity/chemotaxis. Chromosomal Location of Human Ortholog: 19q13.4. Cellular Component: sarcomere; troponin complex; cytosol. Molecular Function: troponin T binding; protein domain specific binding; troponin C binding; protein binding; metal ion binding; calcium channel inhibitor activity; actin binding; protein kinase binding; calcium-dependent protein binding. Biological Process: regulation of smooth muscle contraction; cellular calcium ion homeostasis; heart contraction; regulation of systemic arterial blood pressure by ischemic conditions; heart development; ventricular cardiac muscle morphogenesis; vasculogenesis; negative regulation of ATPase activity; cardiac muscle contraction; muscle filament sliding. Disease: Cardiomyopathy, Dilated, 1ff; Cardiomyopathy, Familial Restrictive, 1; Cardiomyopathy, Familial Hypertrophic, 7; Cardiomyopathy, Dilated, 2a

1 mg

560 USD