protein

BETA 2 MICROGLOBULIN

MBS319462

1 mg

350 USD

Protein

BETA 2 MICROGLOBULIN

[Beta 2 Microglobulin]

[beta-2-microglobulin; Beta-2-microglobulin; beta-2-microglobulin; beta-2-microglobin; beta chain of MHC class I molecules; beta-2-microglobulin]

[B2M; B2M]

B2MG_HUMAN

Beta 2 Microglobulin

>= 98% Purity (SDS-PAGE). Purification by proprietary methods.

Purified, Lyophilized

Reconstitute with PBS, pH > 7.0 with 0.15 M Sodium Chloride.

Store at 2-8 degree C. After reconstitution, aliquot and store at -20 degree C for up to 6 months.

Specific methodologies have not been tested using this product.

Buffer: Lyophilized from 0.02 M Ammonium Bicarbonate. May contain traces of buffer salts. Preservative: None. Warning: All human source materials have tested non-reactive for HIV 1, HCV, HBV by NAT, HBsAg, HCV, HIV 1 & 2 antibodies and RPR by currently approved FDA methods. No test guarantees a product to be noninfectious. Therefore, all material derived from human fluids or tissues should be considered as potentially infectious.

Purified Proteins and Bioactive Peptides

Beta 2 Microglobulin. Human Beta 2 Microglobulin

4757826

NP_004039.1

NM_004048.2

P61769

13,715 Da

Adaptive Immune System Pathway (366160); Amyloids Pathway (366238); Antigen Presentation: Folding, Assembly And Peptide Loading Of Class I MHC Pathway (366163); Antigen Processing And Presentation Pathway (83074); Antigen Processing And Presentation Pathway (485); Antigen Processing-Cross Presentation Pathway (477122); Class I MHC Mediated Antigen Processing Presentation Pathway (366161); Cytokine Signaling In Immune System Pathway (366171); DAP12 Interactions Pathway (685549); DAP12 Signaling Pathway (685550)

This gene encodes a serum protein found in association with the major histocompatibility complex (MHC) class I heavy chain on the surface of nearly all nucleated cells. The protein has a predominantly beta-pleated sheet structure that can form amyloid fibrils in some pathological conditions. A mutation in this gene has been shown to result in hypercatabolic hypoproteinemia.[provided by RefSeq, Sep 2009]

Function: Component of the class I major histocompatibility complex (MHC). Involved in the presentation of peptide antigens to the immune system. Subunit structure: Heterodimer of an alpha chain and a beta chain. Beta-2-microglobulin is the beta-chain of major histocompatibility complex class I molecules. Polymers of beta 2-microglobulin can be found in tissues from patients on long-term hemodialysis. Ref.14. Subcellular location: Secreted. Note: Detected in serum and urine. Ref.16 Ref.17. Post-translational modification: Glycation of Ile-21 is observed in long-term hemodialysis patients. Involvement in disease: Hypercatabolic hypoproteinemia (HYCATHYP) [MIM:241600]: Affected individuals show marked reduction in serum concentrations of immunoglobulin and albumin, probably due to rapid degradation.Note: The disease is caused by mutations affecting the gene represented in this entry. Ref.33Beta-2-microglobulin may adopt the fibrillar configuration of amyloid in certain pathologic states. The capacity to assemble into amyloid fibrils is concentration dependent. Persistently high beta(2)-microglobulin serum levels lead to amyloidosis in patients on long-term hemodialysis. Ref.13 Ref.14 Ref.15 Ref.16 Ref.17 Ref.25 Ref.26 Ref.27 Ref.28 Ref.29 Ref.30 Ref.31 Ref.32. Sequence similarities: Belongs to the beta-2-microglobulin family.Contains 1 Ig-like C1-type (immunoglobulin-like) domain.

1 mg

350 USD