protein

hGH, Recombinant

MBS319391

0.1 mg

170 USD

Recombinant Protein

hGH, Recombinant

Growth Hormone, Recombinant

hGH, Recombinant; Human Growth Hormone (hGH), Recombinant

growth hormone; Somatotropin; somatotropin; pituitary growth hormone; growth hormone 1; Growth hormone; GH; GH-N; Growth hormone 1; Pituitary growth hormone

GH1; GH1; GH; GHN; GH-N; hGH-N; IGHD1B

SOMA_HUMAN

E Coli

Human

Growth Hormone, Recombinant

>98% pure (RP-HPLC and SDS-PAGE). Purified by chromatographic techniques. Product is sterile filtered.

Purified, Lyophilized. Reconstitute using sterile deionized water to a concentration >100ug/ml. Further dilutions can be made in other aqueous buffers.

Total protein: 1mg/ml (OD280nm, E 0.1% = 0.72). Activity: 3Units/mg

The lyophilized product, though stable for 3 weeks at room temperature, is best stored at -20 degree C. After reconstitution, short term (up to 1 week) store at 2-8 degree C. Long term, add 0.1% HSA or BSA, aliquot and store at -20 degree C. Avoid multiple freeze/thaw cycles.

Buffer: Lyophilized from sodium phosphate buffer containing mannitol. Preservative: No Preservative

Purified Hormones and Steroids

Recombinant Human growth hormone (hGH) is a single, non-glycosylated, polypeptide chain containing 192 amino acids. Molecular weight: 22,260Da. The sequence of the first five N-terminal amino acids was determined to be Met-Phe-Pro-Thr-Ile.

183157

P01241

24,847 Da

Adipogenesis Pathway 198832!!Cytokine-cytokine Receptor Interaction Pathway 83051!!Cytokine-cytokine Receptor Interaction Pathway 460!!Diabetes Pathways 105902!!Endochondral Ossification Pathway 198812!!Jak-STAT Signaling Pathway 83077!!Jak-STAT Signaling Pathway 488!!Neuroactive Ligand-receptor Interaction Pathway 83053!!Neuroactive Ligand-receptor Interaction Pathway 462!!Synthesis, Secretion, And Deacylation Of Ghrelin Pathway 119538

The protein encoded by this gene is a member of the somatotropin/prolactin family of hormones which play an important role in growth control. The gene, along with four other related genes, is located at the growth hormone locus on chromosome 17 where they are interspersed in the same transcriptional orientation; an arrangement which is thought to have evolved by a series of gene duplications. The five genes share a remarkably high degree of sequence identity. Alternative splicing generates additional isoforms of each of the five growth hormones, leading to further diversity and potential for specialization. This particular family member is expressed in the pituitary but not in placental tissue as is the case for the other four genes in the growth hormone locus. Mutations in or deletions of the gene lead to growth hormone deficiency and short stature. [provided by RefSeq]

Function: Plays an important role in growth control. Its major role in stimulating body growth is to stimulate the liver and other tissues to secrete IGF-1. It stimulates both the differentiation and proliferation of myoblasts. It also stimulates amino acid uptake and protein synthesis in muscle and other tissues. Subunit structure: Monomer, dimer, trimer, tetramer and pentamer, disulfide-linked or non-covalently associated, in homopolymeric and heteropolymeric combinations. Can also form a complex either with GHBP or with the alpha2-macroglobulin complex. Subcellular location: Secreted. Involvement in disease: Defects in GH1 are a cause of growth hormone deficiency isolated type 1A (IGHD1A) [. MIM:262400]; also known as pituitary dwarfism I. IGHD1A is an autosomal recessive deficiency of GH which causes short stature. IGHD1A patients have an absence of GH with severe dwarfism and often develop anti-GH antibodies when given exogenous GH. Ref.19Defects in GH1 are a cause of growth hormone deficiency isolated type 1B (IGHD1B) [. MIM:612781]; also known as dwarfism of Sindh. IGHD1B is an autosomal recessive deficiency of GH which causes short stature. IGHD1B patients have low but detectable levels of GH. Dwarfism is less severe than in IGHD1A and patients usually respond well to exogenous GH.Defects in GH1 are the cause of Kowarski syndrome (KWKS) [. MIM:262650]; also known as pituitary dwarfism VI. Ref.28 Ref.31 Ref.38Defects in GH1 are a cause of growth hormone deficiency isolated type 2 (IGHD2) [. MIM:173100]. IGHD2 is an autosomal dominant deficiency of GH which causes short stature. Clinical severity is variable. Patients have a positive response and immunologic tolerance to growth hormone therapy. Pharmaceutical use: Available under the names Nutropin or Protropin (Genentech), Norditropin (Novo Nordisk), Genotropin (Pharmacia Upjohn), Humatrope (Eli Lilly) and Saizen or Serostim (Serono). Used for the treatment of growth hormone deficiency and for Turner's syndrome. Miscellaneous: Circulating GH shows a great heterogeneity due to alternative splicing, differential post-translational modifications of monomeric forms, oligomerization, optional binding to 2 different GH-binding proteins, and potentially proteolytic processing. Sequence similarities: Belongs to the somatotropin/prolactin family.

0.1 mg

170 USD