Cystatin C, Recombinant | MyBioSource MBS319387 product information

product summary

company name :

MyBioSource

product type :

protein

product name :

Cystatin C, Recombinant

catalog :

MBS319387

quantity :

1 mg

price :

1335 USD

more info or order :

MyBioSource product webpage

product information

catalog number :

MBS319387

products type :

Recombinant Protein

products full name :

Cystatin C, Recombinant

products short name :

Cystatin C, Recombinant

products name syn :

Cystatin C, Recombinant

other names :

cystatin-C; Cystatin-C; cystatin-C; cystatin 3; cystatin-3; gamma-trace; OTTHUMP00000030440; OTTHUMP00000164181; OTTHUMP00000164182; post-gamma-globulin; bA218C14.4 (cystatin C); neuroendocrine basic polypeptide; cystatin C; Cystatin-3; Gamma-trace; Neuroendocrine basic polypeptide; Post-gamma-globulin

other gene names :

CST3; CST3; ARMD11; MGC117328

uniprot entry name :

CYTC_HUMAN

host :

E. coli

specificity :

Cystatin C, Recombinant

purity :

>95% pure (SDS-PAGE). Immunoaffinity and size-exclusion chromatography

form :

Affinity Purified, Lyophilized. Reconstitute with deionized water.

storage stability :

Store lyophilized product at -70 degree C. After reconstitution, aliquot and store at -70 degree C. Avoid multiple freeze/thaw cycles.

tested application :

Immunoassay

app notes :

Calibrator or standard in immunoassays, immunogen for antibody production

other info1 :

Buffer: Lyophilized from 50mM Tris-HCl, pH 7.6 containing 150mM Sodium chloride. Preservative: None

other info2 :

Inactivation: Not applicable

products categories :

Purified Proteins and Bioactive Peptides

products description :

A single polypeptide chain corresponding to mature secreted Cystatin C (120 a.a.). Immunoreactivity is checked using monoclonal antibodies specific to Cystatin C. Recombinant protein has the same sequence as native protein with additional Met residue at the N-terminus of the molecule. Does not contain a fusion partner.

ncbi gi num :

4503107

ncbi acc num :

NP_000090.1

ncbi gb acc num :

NM_000099.2

uniprot acc num :

P01034

ncbi mol weight :

15,799 Da

ncbi pathways :

Amyloids Pathway (366238); Salivary Secretion Pathway (153376); Salivary Secretion Pathway (153352)

ncbi summary :

The cystatin superfamily encompasses proteins that contain multiple cystatin-like sequences. Some of the members are active cysteine protease inhibitors, while others have lost or perhaps never acquired this inhibitory activity. There are three inhibitory families in the superfamily, including the type 1 cystatins (stefins), type 2 cystatins and the kininogens. The type 2 cystatin proteins are a class of cysteine proteinase inhibitors found in a variety of human fluids and secretions, where they appear to provide protective functions. The cystatin locus on chromosome 20 contains the majority of the type 2 cystatin genes and pseudogenes. This gene is located in the cystatin locus and encodes the most abundant extracellular inhibitor of cysteine proteases, which is found in high concentrations in biological fluids and is expressed in virtually all organs of the body. A mutation in this gene has been associated with amyloid angiopathy. Expression of this protein in vascular wall smooth muscle cells is severely reduced in both atherosclerotic and aneurysmal aortic lesions, establishing its role in vascular disease. [provided by RefSeq]

uniprot summary :

Function: As an inhibitor of cysteine proteinases, this protein is thought to serve an important physiological role as a local regulator of this enzyme activity. Subunit structure: Homodimer. Subcellular location: Secreted Ref.19. Tissue specificity: Expressed in submandibular and sublingual saliva but not in parotid saliva (at protein level). Expressed in various body fluids, such as the cerebrospinal fluid and plasma. Expressed in highest levels in the epididymis, vas deferens, brain, thymus, and ovary and the lowest in the submandibular gland. Ref.16 Ref.19. Post-translational modification: The Thr-25 variant is O-glycosylated with a core 1 or possibly core 8 glycan. The signal peptide of the O-glycosylated Thr-25 variant is cleaved between Ala-20 and Val-21. Ref.18. Involvement in disease: Defects in CST3 are the cause of amyloidosis type 6 (AMYL6) [. MIM:105150]; also known as hereditary cerebral hemorrhage with amyloidosis (HCHWA), cerebral amyloid angiopathy (CAA) or cerebroarterial amyloidosis Icelandic type. AMYL6 is a hereditary generalized amyloidosis due to cystatin C amyloid deposition. Cystatin C amyloid accumulates in the walls of arteries, arterioles, and sometimes capillaries and veins of the brain, and in various organs including lymphoid tissue, spleen, salivary glands, and seminal vesicles. Amyloid deposition in the cerebral vessels results in cerebral amyloid angiopathy, cerebral hemorrhage and premature stroke. Cystatin C levels in the cerebrospinal fluid are abnormally low. Ref.3 Ref.22Genetic variations in CST3 are associated with age-related macular degeneration type 11 (ARMD11) [. MIM:611953]. ARMD is a multifactorial eye disease and the most common cause of irreversible vision loss in the developed world. In most patients, the disease is manifest as ophthalmoscopically visible yellowish accumulations of protein and lipid that lie beneath the retinal pigment epithelium and within an elastin-containing structure known as Bruch membrane. Ref.23. Miscellaneous: Potential cerebrospinal fluid marker for the diagnosis of Creutzfeldt-Jakob disease. Sequence similarities: Belongs to the cystatin family. Mass spectrometry: Molecular mass is 13334.5829 0.0140 Da from positions 27 - 146. Determined by ESI. Ref.19

size1 :

1 mg

price1 :

1335 USD

more info or order :

MyBioSource product webpage