protein

Mouse PAI-1, Recombinant

MBS319078

0.5 mg

1245 USD

Recombinant Protein

Mouse PAI-1, Recombinant

Plasminogen Activator Inhibitor 1, Recombinant

plasminogen activator inhibitor 1 isoform 1; Plasminogen activator inhibitor 1; plasminogen activator inhibitor 1; serpin E1; OTTHUMP00000211478; endothelial plasminogen activator inhibitor; serine (or cysteine) proteinase inhibitor, clade E (nexin, plasminogen activator inhibitor type 1), member 1; serpin peptidase inhibitor, clade E (nexin, plasminogen activator inhibitor type 1), member 1; Endothelial plasminogen activator inhibitor; Serpin E1

SERPINE1; SERPINE1; PAI; PAI1; PAI-1; PLANH1; PAI1; PLANH1

PAI1_HUMAN

E Coli

Mouse

Plasminogen Activator Inhibitor 1, Recombinant

>98% pure (SDS-PAGE). 80 + 5% active by uPA titration. Column chromatography

Purified, Liquid

2.4mg/ml (OD280nm, E0.1% = 1.0)

Store at -70 degree C. Avoid multiple freeze/thaw cycles.

Inactivation: Not applicable.

Buffer: 0.05M Sodium acetate, 0.1M Sodium chloride, 1mM EDTA, pH 5.0. Preservative: No. Dry Ice Shipment: Extra charge fee may add to your shipping cost as dry ice is required to ship this product.

Purified Platelets and Hemostasis Antigens

Mouse Plasminogen Activator Inhibitor 1 (PAI-1) (wild type), Recombinant. Does not contain a fusion partner. Molecular weight: 43kDa

10835159

NP_000593.1

NM_000602.3

P05121

45,060 Da

Adipogenesis Pathway 198832!!Blood Clotting Cascade Pathway 198840!!Chagas Disease (American Trypanosomiasis) Pathway 147809!!Chagas Disease (American Trypanosomiasis) Pathway 147795!!Circadian Clock Pathway 187173!!Complement And Coagulation Cascades Pathway 198880!!Complement And Coagulation Cascades Pathway 83073!!Complement And Coagulation Cascades Pathway 484!!Direct P53 Effectors Pathway 137939!!Dissolution Of Fibrin Clot Pathway 106061

This gene encodes a member of the serine proteinase inhibitor (serpin) superfamily. This member is the principal inhibitor of tissue plasminogen activator (tPA) and urokinase (uPA), and hence is an inhibitor of fibrinolysis. Defects in this gene are the cause of plasminogen activator inhibitor-1 deficiency (PAI-1 deficiency), and high concentrations of the gene product are associated with thrombophilia. Alternatively spliced transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq]

Function: This inhibitor acts as 'bait' for tissue plasminogen activator, urokinase, and protein C. Its rapid interaction with TPA may function as a major control point in the regulation of fibrinolysis. Subunit structure: Interacts with VTN. Binds LRP1B; binding is followed by internalization and degradation. Ref.14 Ref.16. Subcellular location: Secreted. Tissue specificity: Found in plasma and platelets and in endothelial, hepatoma and fibrosarcoma cells. Post-translational modification: Inactivated by proteolytic attack of the urokinase-type (u-PA) and the tissue-type (TPA), cleaving the 369-Arg- -Met-370 bond. Involvement in disease: Defects in SERPINE1 are the cause of plasminogen activator inhibitor-1 deficiency (PAI-1D) [. MIM:613329]. It is a hematologic disorder characterized by increased bleeding after trauma, injury, or surgery. Affected females have menorrhagia. The bleeding defect is due to increased fibrinolysis of fibrin blood clots due to deficiency of plasminogen activator inhibitor-1, which inhibits tissue and urinary activators of plasminogen. Ref.15Note=High concentrations of SERPINE1 seem to contribute to the development of venous but not arterial occlusions. Sequence similarities: Belongs to the serpin family.

0.5 mg

1245 USD