catalog number :
MBS319050
products type :
Recombinant Protein
products full name :
TGF Beta 3, Recombinant
products short name :
Transforming Growth Factor-beta 3 (TGF-b3) Recombinant
products name syn :
Recombinant Human Transforming Growth Factor-beta 3 (TGF)
other names :
transforming growth factor-beta 3; Transforming growth factor beta-3; transforming growth factor beta-3; TGF-beta-3; transforming growth factor, beta 3
other gene names :
TGFB3; TGFB3; ARVD; FLJ16571; TGF-beta3
uniprot entry name :
TGFB3_HUMAN
specificity :
Transforming Growth Factor-beta 3 (TGF-b3) Recombinant
purity :
>99% pure (SDS-PAGE Silver Stained gel, reducing and non-reducing). Purified using standard chromatographic techniques. Product is sterile filtered.
concentration :
0.25mg/ml
storage stability :
Store at 2 to 8 degree C. For long-term storage, it is recommended to add a carrier protein (0.1% HSA or BSA).
other info1 :
Immunogen: N-terminal amino acids was determined and found to be Ala-Leu-Asp-Thr-Asn. Contains less than 1% dimers and aggregates. Inactivation: Not applicable
other info2 :
Buffer: 20% ethanol and 0.1% acetate. Preservative: No
products categories :
Purified Cytokines and Growth Factors
products description :
Recombinant Human TGF- beta 3 is a single, non-glycosylated, polypeptide chain containing 112 amino acids and having a molecular mass of 25,445 Dalton. The sequence of the first five
ncbi acc num :
AAC79727.1
ncbi mol weight :
47,328 Da
ncbi pathways :
ALK1 Signaling Events Pathway 137968!!Amoebiasis Pathway 167324!!Amoebiasis Pathway 167191!!Cell Cycle Pathway 83054!!Cell Cycle Pathway 463!!Chagas Disease (American Trypanosomiasis) Pathway 147809!!Chagas Disease (American Trypanosomiasis) Pathway 147795!!Chronic Myeloid Leukemia Pathway 83116!!Chronic Myeloid Leukemia Pathway 528!!Colorectal Cancer Pathway 83106
ncbi summary :
This gene encodes a member of the TGF-beta family of proteins. The encoded protein is secreted and is involved in embryogenesis and cell differentiation. Defects in this gene are a cause of familial arrhythmogenic right ventricular dysplasia 1. [provided by RefSeq]
uniprot summary :
Function: Involved in embryogenesis and cell differentiation. Subunit structure: Homodimer; disulfide-linked. Interacts with ASPN. Ref.8. Subcellular location: Secreted. Involvement in disease: Defects in TGFB3 are a cause of familial arrhythmogenic right ventricular dysplasia type 1 (ARVD1) [. MIM:107970]; also known as arrhythmogenic right ventricular cardiomyopathy 1 (ARVC1). ARVD is an autosomal dominant disease characterized by partial degeneration of the myocardium of the right ventricle, electrical instability, and sudden death. It is clinically defined by electrocardiographic and angiographic criteria; pathologic findings, replacement of ventricular myocardium with fatty and fibrous elements, preferentially involve the right ventricular free wall. Ref.10. Sequence similarities: Belongs to the TGF-beta family. Sequence caution: The sequence CAA33024.1 differs from that shown. Reason: Erroneous initiation.