protein

Prostate Specific Antigen

MBS318585

0.1 mg

355 USD

Native Protein

Prostate Specific Antigen

Prostate Specific Antigen (PSA) >98% Pure

Prostate Specific Antigen (PSA) >98% Pure

prostate-specific antigen isoform 1 preproprotein; Prostate-specific antigen; prostate-specific antigen; seminin; P-30 antigen; kallikrein-3; semenogelase; gamma-seminoprotein; prostate specific antigen; kallikrein-related peptidase 3; Gamma-seminoprotein; Seminin; Kallikrein-3; P-30 antigen; Semenogelase

KLK3; KLK3; APS; PSA; hK3; KLK2A1; APS

KLK3_HUMAN

Human Seminal Fluid

261

Prostate Specific Antigen (PSA) >98% Pure

>98% pure Product is 0.2um filtered.

Purified, Liquid

5.64mg/ml

Store at 2 to 8 degree C. DO NOT FREEZE!

Inactivation: Not applicable

Buffer: 0.05M Phosphate buffer containing 0.15M Sodium chloride, pH 7.5. Preservative: 0.1% Sodium azide. Warnings: All human source materials have tested negative for HIV1, HIV2, HCV antibodies, HIV-1 Antigen, HBsAg and Syphilis by current FDA approval methods. No test guarantees a product to be non-infectious. Therefore, all material derived from human flui

Purified Reagents for Cancer Research

Free PSA. Molecular weight 34kDa (monomeric protein)

4502173

NP_001639.1

NM_001648.2

P07288

28,741 Da

Coregulation Of Androgen Receptor Activity Pathway (138085); Diabetes Pathways (105902); FOXA1 Transcription Factor Network Pathway (137979); Pathways In Cancer (83105); Prostate Cancer Pathway (83111); Prostate Cancer Pathway (523); Regulation Of Androgen Receptor Activity Pathway (138027); Regulation Of Insulin-like Growth Factor (IGF) Activity By Insulin-like Growth Factor Binding Proteins (IGFBPs) Pathway (105908)

Kallikreins are a subgroup of serine proteases having diverse physiological functions. Growing evidence suggests that many kallikreins are implicated in carcinogenesis and some have potential as novel cancer and other disease biomarkers. This gene is one of the fifteen kallikrein subfamily members located in a cluster on chromosome 19. Its protein product is a protease present in seminal plasma. It is thought to function normally in the liquefaction of seminal coagulum, presumably by hydrolysis of the high molecular mass seminal vesicle protein. Serum level of this protein, called PSA in the clinical setting, is useful in the diagnosis and monitoring of prostatic carcinoma. Alternate splicing of this gene generates several transcript variants encoding different isoforms. [provided by RefSeq]

Function: Hydrolyzes semenogelin-1 thus leading to the liquefaction of the seminal coagulum. Catalytic activity: Preferential cleavage: -Tyr- -Xaa-. Enzyme regulation: Activity is strongly inhibited by Zn2+, 100 times more abundant in semen than in serum. This inhibition is relieved by exposure to semenogelins, which are avid zinc binders. Ref.18. Subcellular location: Secreted. Sequence similarities: Belongs to the peptidase S1 family. Kallikrein subfamily.Contains 1 peptidase S1 domain. Sequence caution: The sequence AAD14185.1 differs from that shown. Reason: Erroneous initiation.

0.1 mg

355 USD