protein

Soluble Transferrin Receptor

MBS318313

0.1 mg

980 USD

Native Protein

Soluble Transferrin Receptor

Transferrin Receptor, Soluble

transferrin receptor protein 1; Transferrin receptor protein 1; transferrin receptor protein 1; T9; TR; p90; OTTHUMP00000208523; OTTHUMP00000208524; OTTHUMP00000208525; transferrin receptor (p90, CD71); T9; p90

TFRC; TFRC; TFR; CD71; TFR1; TRFR

TFR1_HUMAN

Human Blood

760

Transferrin Receptor, Soluble

>95% pure (SDS-PAGE). Immunoaffinity purified

Affinity Purified, Lyophilized. Reconstitute in deionized water.

Store lyophilized product at -20 degree C. After reconstitution, store at 2 to 8 degree. DO NOT FREEZE after reconstitution.

EIA/ELISA

Inactivation: Not applicable

Buffer: Lyophilized from 10mM Tris-HCl containing 0.15M Sodium chloride, 5% Mannitol, 0.1% CHAPS. Preservative: No. Lyophilized: Yes. Warnings: All human source materials have tested negative for HIV1, HIV2, HCV antibodies and HBsAg and Syphilis. No test guarantees a product to be non-infectious. Therefore, all material derived from human fluids or tissues should be considered as potent

Purified Proteins and Bioactive Peptides

189458819

NP_001121620.1

NM_001128148.1

P02786

84,871 Da

Clathrin Derived Vesicle Budding Pathway (119545); Endocytosis Pathway (102279); Endocytosis Pathway (102181); FOXA2 And FOXA3 Transcription Factor Networks Pathway (137911); Golgi Associated Vesicle Biogenesis Pathway (119546); HIF-1-alpha Transcription Factor Network Pathway (138045); Hematopoietic Cell Lineage Pathway (83078); Hematopoietic Cell Lineage Pathway (489); Iron Uptake And Transport Pathway (187191); Membrane Trafficking Pathway (106160)

Function: Cellular uptake of iron occurs via receptor-mediated endocytosis of ligand-occupied transferrin receptor into specialized endosomes. Endosomal acidification leads to iron release. The apotransferrin-receptor complex is then recycled to the cell surface with a return to neutral pH and the concomitant loss of affinity of apotransferrin for its receptor. Transferrin receptor is necessary for development of erythrocytes and the nervous system. By similarity. A second ligand, the heditary hemochromatosis protein HFE, competes for binding with transferrin for an overlapping C-terminal binding site. Ref.13. Subunit structure: Homodimer; disulfide-linked. Binds one transferrin or HFE molecule per subunit. Binds the HLA class II histocompatibility antigen, DR1. Interacts with SH3BP3. Interacts with Machupo arenavirus GPC. Ref.25 Ref.30. Subcellular location: Cell membrane; Single-pass type II membrane protein. Melanosome. Note: Identified by mass spectrometry in melanosome fractions from stage I to stage IV. Ref.29Transferrin receptor protein 1, serum form: Secreted Ref.29. Induction: Regulated by cellular iron levels through binding of the iron regulatory proteins, IRP1 and IRP2, to iron-responsive elements in the 3'-UTR. Up-regulated upon mitogenic stimulation. Post-translational modification: N- and O-glycosylated, phosphorylated and palmitoylated. The serum form is only glycosylated. Ref.27 Ref.28 Ref.31 Ref.32 Ref.34Proteolytically cleaved on Arg-100 to produce the soluble serum form (sTfR).Palmitoylated on both Cys-62 and Cys-67. Cys-62 seems to be the major site of palmitoylation. Ref.14. Miscellaneous: Serum transferrin receptor (sTfR) is used as a means of detecting erythropoietin (EPO) misuse by athletes and as a diagnostic test for anemia resulting from a number of conditions including rheumatoid arthritis, pregnancy, irritable bowel syndrome and in HIV patients.Canine and feline parvoviruses bind human and feline transferrin receptors and use these receptors to enter and infect cells. Sequence similarities: Belongs to the peptidase M28 family. M28B subfamily.Contains 1 PA (protease associated) domain. Sequence caution: The sequence BAD92491.1 differs from that shown. Reason: Erroneous initiation.

0.1 mg

980 USD