Human Brain S-100b Protein | MyBioSource MBS318295 product information

product summary

company name :

MyBioSource

product type :

protein

product name :

Human Brain S-100b Protein

catalog :

MBS318295

quantity :

1 mg

price :

2240 USD

more info or order :

MyBioSource product webpage

product information

catalog number :

MBS318295

products type :

Native Protein

products full name :

Human Brain S-100b Protein

products short name :

S-100B, Protein (beta-beta)

products name syn :

Human Brain S-100 beta-beta homodimer (S100b) Protein

other names :

protein S100-B; Protein S100-B; protein S100-B; OTTHUMP00000115888; S-100 protein subunit beta; S-100 calcium-binding protein, beta chain; S100 calcium-binding protein, beta (neural); S100 calcium binding protein B; S-100 protein beta chain; S-100 protein subunit beta; S100 calcium-binding protein B

other gene names :

S100B; S100B; NEF; S100; S100-B; S100beta

uniprot entry name :

S100B_HUMAN

host :

Human Brain Tissue

sequence length :

specificity :

S-100B, Protein (beta-beta)

purity :

>95% pure

form :

Purified, Lyophilized. Reconstitute in 5mM 2-mercaptoethanol solution

storage stability :

Upon receipt, store lyophilized product at -20 degree C. After reconstitution, aliquot and store at -20 degree C. Avoid multiple freeze/thaw cycles.

other info1 :

Inactivation: Not applicable

other info2 :

Buffer: Lyophilized from 5mM Tris-HCl, pH 7.5 containing 5mM 2-mercaptoethanol and 2mM EDTA. Preservative: No. Lyophilized: Yes. Warnings: Blood samples from tissue donors have tested negative for HIV1, HIV2, HCV antibodies HBsAg and syphilis. No test guarantees a product to be non-infectious. Therefore, all material derived from human fluids or tissues should be considered as pote

products categories :

Purified Neuroscience Reagents

ncbi gi num :

5454034

ncbi acc num :

NP_006263.1

ncbi gb acc num :

NM_006272.2

uniprot acc num :

P04271

ncbi mol weight :

10,713 Da

ncbi pathways :

Activated TLR4 Signalling Pathway (106400); Advanced Glycosylation Endproduct Receptor Signaling Pathway (187092); Immune System Pathway (106386); Innate Immunity Signaling Pathway (106387); MyD88 Cascade Initiated On Plasma Membrane Pathway (205107); MyD88 Dependent Cascade Initiated On Endosome Pathway (187081); MyD88-independent Cascade Initiated On Plasma Membrane Pathway (106401); MyD88:Mal Cascade Initiated On Plasma Membrane Pathway (106390); NFkB And MAP Kinases Activation Mediated By TLR4 Signaling Repertoire Pathway (187089); RIG-I/MDA5 Mediated Induction Of IFN-alpha/beta Pathways (187097)

ncbi summary :

The protein encoded by this gene is a member of the S100 family of proteins containing 2 EF-hand calcium-binding motifs. S100 proteins are localized in the cytoplasm and/or nucleus of a wide range of cells, and involved in the regulation of a number of cellular processes such as cell cycle progression and differentiation. S100 genes include at least 13 members which are located as a cluster on chromosome 1q21; however, this gene is located at 21q22.3. This protein may function in Neurite extension, proliferation of melanoma cells, stimulation of Ca2+ fluxes, inhibition of PKC-mediated phosphorylation, astrocytosis and axonal proliferation, and inhibition of microtubule assembly. Chromosomal rearrangements and altered expression of this gene have been implicated in several neurological, neoplastic, and other types of diseases, including Alzheimer's disease, Down's syndrome, epilepsy, amyotrophic lateral sclerosis, melanoma, and type I diabetes. [provided by RefSeq]

uniprot summary :

Function: Weakly binds calcium but binds zinc very tightly-distinct binding sites with different affinities exist for both ions on each monomer. Physiological concentrations of potassium ion antagonize the binding of both divalent cations, especially affecting high-affinity calcium-binding sites. Binds to and initiates the activation of STK38 by releasing autoinhibitory intramolecular interactions within the kinase. Interaction with AGER after myocardial infarction may play a role in myocyte apoptosis by activating ERK1/2 and p53/TP53 signaling. Subunit structure: Dimer of either two alpha chains, or two beta chains, or one alpha and one beta chain. The S100B dimer binds two molecules of STK38. Interacts with AGER. By similarity. The S100B dimer interacts with two molecules of CAPZA1. Ref.8. Subcellular location: Cytoplasm. Nucleus Ref.8. Tissue specificity: Although predominant among the water-soluble brain proteins, S100 is also found in a variety of other tissues. Miscellaneous: In addition to metal-ion binding, this protein is involved with the regulation of protein phosphorylation in brain tissue. Sequence similarities: Belongs to the S-101 family.Contains 2 EF-hand domains.

size1 :

1 mg

price1 :

2240 USD

more info or order :

MyBioSource product webpage