protein

Human Vitronectin

MBS318228

0.1 mg

470 USD

Native Protein

Human Vitronectin

Vitronectin

vitronectin; Vitronectin; vitronectin; epibolin; S-protein; somatomedin B; OTTHUMP00000163323; complement S-protein; serum spreading factor; serum-spreading factor; vitronectin; S-protein; Serum-spreading factor; V75

VTN; VTN; VN; V75; VNT

VTNC_HUMAN

Human plasma

Human

478

Vitronectin

>95% pure (SDS-PAGE). Column chromatography

Purified, Liquid

3.8mg/ml (OD280nm, E^0.1% = 1.38)

Store at -70 degree C. Avoid multiple freeze/thaw cycles.

Second order rate constants for inhibition of:. uPA = 6.3 x 10^6 M^-1 s^-1. tPA = 5.7 x 10^6 M^-1 s^-1

Inactivation: Not applicable.

Buffer: 0.05M Sodium phosphate, pH 7.4 containing 0.1M Sodium chloride. Preservative: No. Dry Ice Shipment: Extra charge fee may add to your shipping cost as dry ice is required to ship this product. Warnings: All human source materials have tested negative for HIV1, HIV2, HCV antibodies and HBsAg. No test guarantees a product to be non-infectious. Therefore, all material derived from human fluids or tissues should be considered as potentially infectious.

Purified Platelets and Hemostasis Antigens

14326449

AAK60270.1

P04004

54,306 Da

ECM-receptor Interaction Pathway (83068); ECM-receptor Interaction Pathway (479); FOXA1 Transcription Factor Network Pathway (137979); Focal Adhesion Pathway (198795); Focal Adhesion Pathway (83067); Focal Adhesion Pathway (478); Inflammatory Response Pathway (198766); Integrin Cell Surface Interactions Pathway (106110); Integrins In Angiogenesis Pathway (137999); Senescence And Autophagy Pathway (198780)

The protein encoded by this gene is a member of the pexin family. It is found in serum and tissues and promotes cell adhesion and spreading, inhibits the membrane-damaging effect of the terminal cytolytic complement pathway, and binds to several serpin serine protease inhibitors. It is a secreted protein and exists in either a single chain form or a clipped, two chain form held together by a disulfide bond. [provided by RefSeq]

Function: Vitronectin is a cell adhesion and spreading factor found in serum and tissues. Vitronectin interact with glycosaminoglycans and proteoglycans. Is recognized by certain members of the integrin family and serves as a cell-to-substrate adhesion molecule. Inhibitor of the membrane-damaging effect of the terminal cytolytic complement pathway.Somatomedin-B is a growth hormone-dependent serum factor with protease-inhibiting activity. Subunit structure: Exists in two forms: a single chain 75 kDa form (V75) and a clipped form composed of two chains (65 kDa and 10 kDa) (V65+V10) which are held together by a disulfide bond. Interacts with SERPINE1/PAI1 and insulin. Ref.9 Ref.10 Ref.15. Subcellular location: Secreted extracellular space. Tissue specificity: Plasma. Ref.25. Domain: The SMB domain mediates interaction with SERPINE1/PAI1. The heparin-binding domain mediates interaction with insulin. Post-translational modification: Sulfated on 2 tyrosine residues.N- and O-glycosylated. By similarity. Ref.18 Ref.19 Ref.22 Ref.24Phosphorylation on Thr-69 and Thr-76 favors cell adhesion and spreading.It has been suggested that the active SMB domain may be permitted considerable disulfide bond heterogeneity or variability, thus two alternate disulfide patterns based on 3D structures are described with 1 disulfide bond conserved in both.Phosphorylation sites are present in the extracelllular medium. Sequence similarities: Contains 4 hemopexin-like domains.Contains 1 SMB (somatomedin-B) domain.

0.1 mg

470 USD