protein

Human Apolipoprotein CII (APO CII)

MBS318209

0.05 mg

260 USD

Native Protein

Human Apolipoprotein CII (APO CII)

Apolipoprotein CII (Apo CII)

apolipoprotein C-II; Apolipoprotein C-II; apolipoprotein C-II; apolipoprotein C2; apolipoprotein C-II; Apolipoprotein C2

APOC2; APOC2; APO-CII; APOC-II; MGC75082; APC2

APOC2_HUMAN

Human Plasma, Very Low Density Lipoprotein (VLDL)

101

Apolipoprotein CII (Apo CII)

>=95% pure (SDS-PAGE)

Purified, Lyophilized. Reconstitute with 44.6 uL distilled water.

1.12 mg/ml (prior to lyophilization) (Lowry method)

Store at -20 degree C. Avoid multiple freeze/thaw cycles.

Inactivation: Not applicable

Buffer: Lyophilized from 10mM NH4HCO3, pH 7.4. Preservative: No. Lyophilized: Yes. Warnings: All human source materials have tested negative for HIV 1, HIV 2, anti-HCV, anti-HBc antibodies and HBsAg. No test guarantees a product to be non-infectious. Therefore, all material derived from human fluids or tissues should be considered as potentially infectious.

Purified Lipoproteins

32130518

NP_000474.2

NM_000483.4

P02655

11,284 Da

Chylomicron-mediated Lipid Transport Pathway (106157); HDL-mediated Lipid Transport Pathway (106158); Lipid Digestion, Mobilization, And Transport Pathway (106111); Lipoprotein Metabolism Pathway (106156); Metabolism Of Lipids And Lipoproteins Pathway (160976); Statin Pathway (198852)

This gene encodes a lipid-binding protein belonging to the apolipoprotein gene family. The protein is secreted in plasma where it is a component of very low density lipoprotein. This protein activates the enzyme lipoprotein lipase, which hydrolyzes triglycerides and thus provides free fatty acids for cells. Mutations in this gene cause hyperlipoproteinemia type IB, characterized by hypertriglyceridemia, xanthomas, and increased risk of pancreatitis and early atherosclerosis. This gene is present in a cluster with other related apolipoprotein genes on chromosome 19. Naturally occurring read-through transcription exists between this gene and the neighboring upstream apolipoprotein C-IV (APOC4) gene. [provided by RefSeq]

Function: Component of the very low density lipoprotein (VLDL) fraction in plasma, and is an activator of several triacylglycerol lipases. The association of APOC2 with plasma chylomicrons, VLDL, and HDL is reversible, a function of the secretion and catabolism of triglyceride-rich lipoproteins, and changes rapidly. Subcellular location: Secreted. Tissue specificity: Secreted in plasma. Involvement in disease: Defects in APOC2 are the cause of hyperlipoproteinemia type 1B (HLPP1B) [. MIM:207750]. It is an autosomal recessive trait characterized by hypertriglyceridemia, xanthomas, and increased risk of pancreatitis and early atherosclerosis. Ref.22. Sequence similarities: Belongs to the apolipoprotein C2 family.

0.05 mg

260 USD