protein

Human Thrombospondin

MBS318187

0.025 mg

250 USD

Native Protein

Human Thrombospondin

Thrombospondin, Human

thrombospondin; Thrombospondin-1; thrombospondin-1; OTTHUMP00000165029; thrombospondin-1p180; thrombospondin 1

THBS1; THBS1; TSP; THBS; TSP1; TSP-1; THBS-1; TSP; TSP1

TSP1_HUMAN

Human Platelet

Thrombospondin, Human

>95% pure (SDS-PAGE)

Purified, Lyophilized. Reconstitute with 250ul distilled water.

0.152 mg/ml (prior to lyophilization)

Store at -20 degree C. Avoid multiple freeze/thaw cycles.

Inactivation: Not applicable.

Buffer: Lyophilized from 20mM Tris, pH 8.0 containing 600mM Sodium chloride, 2mM CaCl2 and 20% sucrose. Preservative: No. Lyophilized: Yes. Warnings: All human source materials have tested negative for HIV 1 and HIV 2 and non reactive for HBsAg, anti-HCV and anti-HBc by FDA approved tests. No test guarantees a product to be non-infectious. Therefore, all material derived from human fluids or tissues should be considered as potentially infectious.

Purified Platelets and Hemostasis Antigens

A cellular adhesion protein. Thrombospondin is a component of the coagulation mechanism and is believed to have potential as a marker for platelet activation and renal failure.

538354

P07996

129,383 Da

Bladder Cancer Pathway (83115); Bladder Cancer Pathway (527); ECM-receptor Interaction Pathway (83068); ECM-receptor Interaction Pathway (479); Focal Adhesion Pathway (198795); Focal Adhesion Pathway (83067); Focal Adhesion Pathway (478); Formation Of Platelet Plug Pathway (106029); Hemostasis Pathway (106028); Inflammatory Response Pathway (198766)

The protein encoded by this gene is a subunit of a disulfide-linked homotrimeric protein. This protein is an adhesive glycoprotein that mediates cell-to-cell and cell-to-matrix interactions. This protein can bind to fibrinogen, fibronectin, laminin, type V collagen and integrins alpha-V/beta-1. This protein has been shown to play roles in platelet aggregation, angiogenesis, and tumorigenesis. [provided by RefSeq]

Function: Adhesive glycoprotein that mediates cell-to-cell and cell-to-matrix interactions. Binds heparin. May play a role in dentinogenesis and/or maintenance of dentin and dental pulp. By similarity. Ligand for CD36 mediating antiangiogenic properties. Ref.12 Ref.19. Subunit structure: Homotrimer; disulfide-linked. Interacts (via the TSP type I repeats) with HRG; the interaction blocks the antiangiogenic effect of THBS1 with CD36. By similarity. Can bind to fibrinogen, fibronectin, laminin, type V collagen and integrins alpha-V/beta-1, alpha-V/beta-3 and alpha-IIb/beta-3. Interacts (via the TSP type I repeats) with CD36; the interaction conveys an antiangiogenic effect. Ref.10 Ref.12 Ref.13 Ref.18 Ref.19 Ref.20. Sequence similarities: Belongs to the thrombospondin family.Contains 3 EGF-like domains.Contains 1 TSP C-terminal (TSPC) domain.Contains 1 TSP N-terminal (TSPN) domain.Contains 3 TSP type-1 domains.Contains 8 TSP type-3 repeats.Contains 1 VWFC domain.

0.025 mg

250 USD