protein

Purified Human Cathepsin D

MBS318186

0.025 mg

220 USD

Native Protein

Purified Human Cathepsin D

Cathepsin D

cathepsin D; Cathepsin D; cathepsin D; OTTHUMP00000042282; OTTHUMP00000196039; OTTHUMP00000198692; lysosomal aspartyl protease; lysosomal aspartyl peptidase; ceroid-lipofuscinosis, neuronal 10; cathepsin D

CTSD; CTSD; CPSD; CLN10; MGC2311; CPSD

CATD_HUMAN

Human Liver

22

Cathepsin D

>=95% pure (SDS-PAGE)

Purified, Lyophilized. Reconstitute with 28.3ul distilled water.

Protein: 0.883mg/ml (prior to lyophilization). Specific activity: 541 Units/mg (prior to lyophilization). One unit is the amount of enzyme which digests hemoglobin releasing peptides which are soluble in 10% TCA. The reaction is measured by an increas

Store at -20 degree C.

Inactivation: Not applicable.

Buffer: Lyophilized from 2mM Sodium Phosphate, pH 6.5. Preservative: No. Lyophilized: Yes. Warnings: All human source materials have tested negative for HIV 1, HIV 2, anti-HCV, anti-HBc antibodies and HBsAg. No test guarantees a product to be non-infectious. Therefore, all material derived from human fluids or tissues should be considered as po

Purified Reagents for Cancer Research

4261568

AAD13868.1

P07339

44,552 Da

Ceramide Signaling Pathway (138023); Direct P53 Effectors Pathway (137939); LKB1 Signaling Events Pathway (137957); Lysosome Pathway (99052); Lysosome Pathway (96865); Tuberculosis Pathway (213780); Tuberculosis Pathway (213743); Thyroid Hormone Biosynthesis Pathway (138495)

This gene encodes a lysosomal aspartyl protease composed of a dimer of disulfide-linked heavy and light chains, both produced from a single protein precursor. This proteinase, which is a member of the peptidase C1 family, has a specificity similar to but narrower than that of pepsin A. Transcription of this gene is initiated from several sites, including one which is a start site for an estrogen-regulated transcript. Mutations in this gene are involved in the pathogenesis of several diseases, including breast cancer and possibly Alzheimer disease. [provided by RefSeq]

Function: Acid protease active in intracellular protein breakdown. Involved in the pathogenesis of several diseases such as breast cancer and possibly Alzheimer disease. Catalytic activity: Specificity similar to, but narrower than, that of pepsin A. Does not cleave the 4-Gln- -His-5 bond in B chain of insulin. Subunit structure: Consists of a light chain and a heavy chain. Subcellular location: Lysosome. Melanosome. Note: Identified by mass spectrometry in melanosome fractions from stage I to stage IV. Ref.10 Ref.14. Polymorphism: The Val-58 allele is significantly overrepresented in demented patients (11.8%) compared with non-demented controls (4.9%). Carriers of the Val-58 allele have a 3.1-fold increased risk for developing AD than non-carriers. Involvement in disease: Defects in CTSD are the cause of neuronal ceroid lipofuscinosis type 10 (CLN10) [. MIM:610127]; also known as neuronal ceroid lipofuscinosis due to cathepsin D deficiency. A form of neuronal ceroid lipofuscinosis with onset at birth or early childhood. Neuronal ceroid lipofuscinoses are progressive neurodegenerative, lysosomal storage diseases characterized by intracellular accumulation of autofluorescent liposomal material, and clinically by seizures, dementia, visual loss, and/or cerebral atrophy. Ref.13 Ref.21. Sequence similarities: Belongs to the peptidase A1 family.

0.025 mg

220 USD