protein

Human Plasma Ceruloplasmin

MBS318183

1 mg

200 USD

Native Protein

Human Plasma Ceruloplasmin

Ceruloplasmin

ceruloplasmin; Ceruloplasmin; ceruloplasmin; OTTHUMP00000197026; OTTHUMP00000215840; OTTHUMP00000215841; ceruloplasmin (ferroxidase); Ferroxidase

CP; CP; CP-2

CERU_HUMAN

Human Plasma

4

Ceruloplasmin

>95% pure (SDS-PAGE)

Purified, Lyophilized. Reconstitute with 167.1ul distilled water.

5.98mg/ml (prior to lyophilization)

Store at -20 degree C. Avoid multiple freeze/thaw cycles.

Inactivation: Not applicable.

Buffer: Lyophilized from 50mM Potassium phosphate, pH 6.8, 100mM Potassium chloride, 20mM E-amino-n-caproic acid and 5mM EDTA. Preservative: No. Lyophilized: Yes. Warnings: All human source materials have tested negative for HIV-1 and HIV-2 and non-reactive with HCV and HBc antibodies and HBsAg. No test guarantees a product to be non-infectious. Therefore, all material derived from human fluids or tissues should be

Purified Proteins and Bioactive Peptides

1731685

BAA08085.1

P00450

122,205 Da

HIF-1-alpha Transcription Factor Network Pathway (138045); Iron Uptake And Transport Pathway (187191); Metal Ion SLC Transporters Pathway (161066); Porphyrin And Chlorophyll Metabolism Pathway (83021); Porphyrin And Chlorophyll Metabolism Pathway (407); SLC-mediated Transmembrane Transport Pathway (119558); Transmembrane Transport Of Small Molecules Pathway (106572); Transport Of Glucose And Other Sugars, Bile Salts And Organic Acids, Metal Ions And Amine Compounds Pathway (119571)

The protein encoded by this gene is a metalloprotein that binds most of the copper in plasma and is involved in the peroxidation of Fe(II)transferrin to Fe(III) transferrin. Mutations in this gene cause aceruloplasminemia, which results in iron accumulation and tissue damage, and is associated with diabetes and neurologic abnormalities. [provided by RefSeq]

Function: Ceruloplasmin is a blue, copper-binding (6-7 atoms per molecule) glycoprotein. It has ferroxidase activity oxidizing Fe2+ to Fe3+ without releasing radical oxygen species. It is involved in iron transport across the cell membrane. Catalytic activity: 4 Fe2+ + 4 H+ + O2 = 4 Fe3+ + 2 H2O. Cofactor: Binds 6 copper ions per monomer. Subcellular location: Secreted. Tissue specificity: Expressed by the liver and secreted in plasma. Involvement in disease: Defects in CP are the cause of aceruloplasminemia (ACERULOP) [. MIM:604290]. It is an autosomal recessive disorder of iron metabolism characterized by iron accumulation in the brain as well as visceral organs. Clinical features consist of the triad of retinal degeneration, diabetes mellitus and neurological disturbances.Note=Ceruloplasmin levels are decreased in Wilson disease, in which copper cannot be incorporated into ceruloplasmin in liver because of defects in the copper-transporting ATPase 2. Sequence similarities: Belongs to the multicopper oxidase family.Contains 3 F5/8 type A domains.Contains 6 plastocyanin-like domains.

1 mg

200 USD