protein

Human Cathepsin G

MBS318181

0.1 mg

380 USD

Native Protein

Human Cathepsin G

Cathepsin G

cathepsin G; Cathepsin G; cathepsin G; OTTHUMP00000178752; cathepsin G

CTSG; CTSG; CG; CATG; MGC23078

CATG_HUMAN

Human Neutrophil

255

Cathepsin G

>95% pure (SDS-PAGE)

Purified, Lyophilized. We suggest using 50mM Na Acetate, pH 5.5, with 150mM Sodium Chloride as the buffer to be added to the salt-free lyophilized solid.

Not applicable. Activity: 2 to 4 Units/mg protein. One unit of activity is defined as the amount of enzyme that hydrolyzes one micromole of Suc-ala-ala-pro-phe-pNA (1mM) per minute at 25 degree C in 160mM Tris-HCl, pH 7.4 containing 1.6M Sodium chloride

Store at -20 degree C. Avoid multiple freeze/thaw cycles.

Inactivation: Not applicable.

Buffer: Not applicable. Preservative: No. Lyophilized: Yes. Warnings: All human source materials have tested negative for HIV 1, HIV 2 and non-reactive for anti-HCV, HBsAg and anti-HBc. No test guarantees a product to be non-infectious. Therefore, all material derived from human fluids or tissues should be conside

Purified Enzymes

179915

AAA51919.1

P08311

28,837 Da

ACE Inhibitor Pathway (198763); Amoebiasis Pathway (167324); Amoebiasis Pathway (167191); Diabetes Pathways (105902); Lysosome Pathway (99052); Lysosome Pathway (96865); Neuroactive Ligand-receptor Interaction Pathway (83053); Neuroactive Ligand-receptor Interaction Pathway (462); Regulation Of Insulin-like Growth Factor (IGF) Activity By Insulin-like Growth Factor Binding Proteins (IGFBPs) Pathway (105908); Renin-angiotensin System Pathway (83075)

The protein encoded by this gene, a member of the peptidase S1 protein family, is found in azurophil granules of neutrophilic polymorphonuclear leukocytes. The encoded protease has a specificity similar to that of chymotrypsin C, and may participate in the killing and digestion of engulfed pathogens, and in connective tissue remodeling at sites of inflammation. Transcript variants utilizing alternative polyadenylation signals exist for this gene. [provided by RefSeq]

Function: Serine protease with trypsin- and chymotrypsin-like specificity. Cleaves complement C3. Has antibacterial activity against the Gram-negative bacterium P.aeruginosa, antibacterial activity is inhibited by LPS from P.aeruginosa, Z-Gly-Leu-Phe-CH2Cl and phenylmethylsulfonyl fluoride. Ref.6 Ref.9 Ref.11. Catalytic activity: Specificity similar to chymotrypsin C. Enzyme regulation: Inhibited by soybean trypsin inhibitor, benzamidine, the synthetic peptide R13K, Z-Gly-Leu-Phe-CH2Cl, phenylmethylsulfonyl fluoride, 3,4-dichloroisocoumarin, DFP, SBTI and alpha-1-antitrypsin. Inhibited by LPS from P.aeruginosa but not by LPS from S.minnesota. Not inhibited by elastinal, CMK, TLCK and ETDA. Ref.6 Ref.9 Ref.11. Subcellular location: Cell surface Ref.6. Sequence similarities: Belongs to the peptidase S1 family.Contains 1 peptidase S1 domain. Biophysicochemical propertiesKinetic parameters:KM=1.15 mM for Z-Lys-SBzl Ref.6KM=0.26 mM for Suc-Ala-Ala-Pro-Phe-SBzl

0.1 mg

380 USD