protein

Human Erythrocyte Catalase

MBS318179

1 mg

220 USD

Native Protein

Human Erythrocyte Catalase

Catalase

Molecular weight 256kDa (composed of 4 identical subunits of 58kDa each)

catalase; Catalase; catalase; OTTHUMP00000041455; catalase

CAT; CAT; MGC138422; MGC138424

CATA_HUMAN

Human Erythrocyte

527

Catalase

95% pure (SDS-PAGE)

Purified, Liquid

1.29mg/ml. Activity: >50,000 Units/mg protein. One unit is equal to the amount of enzyme that will decompose 1 umole of hydrogen peroxide per minute at 25 degree C, pH 7.0

Store at -20 degree C. Avoid multiple freeze/thaw cycles.

Inactivation: Not applicable.

Buffer: 50mM Tris, pH 8.0. Preservative: No. Dry Ice Shipment: Extra charge fee may add to your shipping cost as dry ice is required to ship this product. Warnings: All human source materials have tested negative for HIV1, HIV2, HCV antibodies and HBsAg. No test guarantees a product to be non-infectious. Therefore, all material derived from human fluids or tissues should be considered as potentially infecti

Purified Enzymes

4557014

NP_001743.1

NM_001752.3

P04040

59,756 Da

Amyotrophic Lateral Sclerosis (ALS) Pathway (83099); Amyotrophic Lateral Sclerosis (ALS) Pathway (511); Folate Metabolism Pathway (198833); FoxO Family Signaling Pathway (138036); Metabolic Pathways (132956); Metabolism Of Nucleotides Pathway (106263); Oxidative Stress Pathway (198916); Peroxisome Pathway (131226); Peroxisome Pathway (131126); Purine Catabolism Pathway (106276)

This gene encodes catalase, a key antioxidant enzyme in the bodies defense against oxidative stress. Catalase is a heme enzyme that is present in the peroxisome of nearly all aerobic cells. Catalase converts the reactive oxygen species hydrogen peroxide to water and oxygen and thereby mitigates the toxic effects of hydrogen peroxide. Oxidative stress is hypothesized to play a role in the development of many chronic or late-onset diseases such as diabetes, asthma, Alzheimer's disease, systemic lupus erythematosus, rheumatoid arthritis, and cancers. Polymorphisms in this gene have been associated with decreases in catalase activity but, to date, acatalasemia is the only disease known to be caused by this gene. [provided by RefSeq]

Function: Occurs in almost all aerobically respiring organisms and serves to protect cells from the toxic effects of hydrogen peroxide. Promotes growth of cells including T-cells, B-cells, myeloid leukemia cells, melanoma cells, mastocytoma cells and normal and transformed fibroblast cells. Ref.11. Catalytic activity: 2 H2O2 = O2 + 2 H2O. Ref.11. Cofactor: Heme group.NADP. Subunit structure: Homotetramer. Subcellular location: Peroxisome. Post-translational modification: The N-terminus is blocked. Involvement in disease: Defects in CAT are the cause of acatalasia (ACATLAS) [. MIM:115500]; also known as acatalasemia. This disease is characterized by absence of catalase activity in red cells and is often associated with ulcerating oral lesions. Sequence similarities: Belongs to the catalase family.

1 mg

220 USD