protein

Human Alpha 2 Macroglobulin

MBS318176

1 mg

205 USD

Native Protein

Human Alpha 2 Macroglobulin

Alpha 2 Macroglobulin

Human Plasma Alpha-2 Macroglobulin

Alpha-2-macroglobulin; Alpha-2-macroglobulin; alpha-2-macroglobulin; alpha-2-M; OTTHUMP00000196829; C3 and PZP-like alpha-2-macroglobulin domain-containing protein 5; alpha-2-macroglobulin; C3 and PZP-like alpha-2-macroglobulin domain-containing protein 5

A2M; A2M; A2MD; CPAMD5; FWP007; S863-7; DKFZp779B086; CPAMD5

A2MG_HUMAN

Human Plasma

1474

Alpha 2 Macroglobulin

>95% pure (SDS-PAGE)

Purified, Lyophilized. Reconstitute with distilled water.

4.90 mg/ml (prior to lyophilization)

Store at -20 degree C. Avoid multiple freeze/thaw cycles.

Specific methodologies have not been tested using this product.

Inactivation: Not applicable.

Buffer: Lyophilized from 30mM Sodium phosphate, pH 7.0 containing 1mg glycine. Preservative: No. Lyophilized: Yes. Warnings: All human source materials have tested negative for HIV 1, HIV 2 and tested non-reactive for anti-HCV, anti-HBc antibodies and HBsAg by FDA required tests. No test guarantees a product to be non-infectious. Therefore, all material derived from human fluids or tissues should be considered as potentially infectious. Important Note: Centrifuge before opening to ensure complete recovery of vial contents.

Purified Proteins and Bioactive Peptides

112911

P01023.1

P01023

163,291 Da

Complement And Coagulation Cascades Pathway (198880); Complement And Coagulation Cascades Pathway (83073); Complement And Coagulation Cascades Pathway (484); Formation Of Fibrin Clot (Clotting Cascade) Pathway (106057); Formation Of Platelet Plug Pathway (106029); HDL-mediated Lipid Transport Pathway (106158); Hemostasis Pathway (106028); IL6-mediated Signaling Events Pathway (137932); Intrinsic Pathway (106059); Lipid Digestion, Mobilization, And Transport Pathway (106111)

Alpha-2-macroglobulin is a protease inhibitor and cytokine transporter. It inhibits many proteases, including trypsin, thrombin and collagenase. A2M is implicated in Alzheimer disease (AD) due to its ability to mediate the clearance and degradation of A-beta, the major component of beta-amyloid deposits. [provided by RefSeq]

Function: Is able to inhibit all four classes of proteinases by a unique 'trapping' mechanism. This protein has a peptide stretch, called the 'bait region' which contains specific cleavage sites for different proteinases. When a proteinase cleaves the bait region, a conformational change is induced in the protein which traps the proteinase. The entrapped enzyme remains active against low molecular weight substrates (activity against high molecular weight substrates is greatly reduced). Following cleavage in the bait region a thioester bond is hydrolyzed and mediates the covalent binding of the protein to the proteinase. Subunit structure: Homotetramer; disulfide-linked. Ref.8 Ref.10. Subcellular location: Secreted Ref.8. Tissue specificity: Secreted in plasma. Ref.8. Developmental stage: Contrary to the rat protein, which is an acute phase protein, this protein is always present at high levels in circulation. Sequence similarities: Belongs to the protease inhibitor I39 (alpha-2-macroglobulin) family. [View classification]. Sequence caution: The sequence AAT02228.1 differs from that shown. Reason: Erroneous initiation. Translation N-terminally shortened.The sequence BAD92851.1 differs from that shown. Reason: Erroneous initiation. Translation N-terminally shortened.

1 mg

205 USD