protein

PSA ACT Complex

MBS318061

0.05 mg

840 USD

Native Protein

PSA ACT Complex

Prostate Specific Antigen (PSA) ACT Complex >95% Pure

Prostate Specific Antigen (PSA) ACT Complex

prostate-specific antigen isoform 1 preproprotein; Prostate-specific antigen; prostate-specific antigen; seminin; P-30 antigen; kallikrein-3; semenogelase; gamma-seminoprotein; prostate specific antigen; kallikrein-related peptidase 3; Gamma-seminoprotein; Seminin; Kallikrein-3; P-30 antigen; Semenogelase

KLK3; KLK3; APS; PSA; hK3; KLK2A1; APS

KLK3_HUMAN

PSA: Human seminal fluid. ACT: Human plasma

261

Prostate Specific Antigen (PSA) ACT Complex >95% Pure

>95% pure (SDS PAGE)

Purified, Liquid

0.418mg/ml (Lowry with BSA standards)

Short-term (up to 3 weeks) store at 2 to 8 degree C. Long term store at -20 degree C. Avoid multiple freeze/thaw cycles.

Inactivation: Not applicable

Buffer: 10mM Sodium acetate, 0.15M Sodium chloride, pH 5.6. Preservative: 0.05% (w/v) Sodium azide. Dry Ice Shipment: Extra charge fee may add to your shipping cost as dry ice is required to ship this product. Warnings: This product contains sodium azide, which has been classified as Xn (Harmful), in European Directive 67/548/EEC in the concentration range of 0.1-1.0%. When disposing of this reagent through lead or copper plumbing, flush with copious volumes of water to prevent azide build-up in drains.

Purified Reagents for Cancer Research

4502173

NP_001639.1

NM_001648.2

P07288

28,741 Da

Coregulation Of Androgen Receptor Activity Pathway 138085!!Diabetes Pathways 105902!!FOXA1 Transcription Factor Network Pathway 137979!!Pathways In Cancer 83105!!Prostate Cancer Pathway 83111!!Prostate Cancer Pathway 523!!Regulation Of Androgen Receptor Activity Pathway 138027!!Regulation Of Insulin-like Growth Factor (IGF) Activity By Insulin-like Growth Factor Binding Proteins (IGFBPs) Pathway 105908

Kallikreins are a subgroup of serine proteases having diverse physiological functions. Growing evidence suggests that many kallikreins are implicated in carcinogenesis and some have potential as novel cancer and other disease biomarkers. This gene is one of the fifteen kallikrein subfamily members located in a cluster on chromosome 19. Its protein product is a protease present in seminal plasma. It is thought to function normally in the liquefaction of seminal coagulum, presumably by hydrolysis of the high molecular mass seminal vesicle protein. Serum level of this protein, called PSA in the clinical setting, is useful in the diagnosis and monitoring of prostatic carcinoma. Alternate splicing of this gene generates several transcript variants encoding different isoforms. [provided by RefSeq]

Function: Hydrolyzes semenogelin-1 thus leading to the liquefaction of the seminal coagulum. Catalytic activity: Preferential cleavage: -Tyr- -Xaa-. Enzyme regulation: Activity is strongly inhibited by Zn2+, 100 times more abundant in semen than in serum. This inhibition is relieved by exposure to semenogelins, which are avid zinc binders. Ref.18. Subcellular location: Secreted. Sequence similarities: Belongs to the peptidase S1 family. Kallikrein subfamily.Contains 1 peptidase S1 domain. Sequence caution: The sequence AAD14185.1 differs from that shown. Reason: Erroneous initiation.

0.05 mg

840 USD