catalog number :
MBS318061
products type :
Native Protein
products full name :
PSA ACT Complex
products short name :
Prostate Specific Antigen (PSA) ACT Complex >95% Pure
products name syn :
Prostate Specific Antigen (PSA) ACT Complex
other names :
prostate-specific antigen isoform 1 preproprotein; Prostate-specific antigen; prostate-specific antigen; seminin; P-30 antigen; kallikrein-3; semenogelase; gamma-seminoprotein; prostate specific antigen; kallikrein-related peptidase 3; Gamma-seminoprotein; Seminin; Kallikrein-3; P-30 antigen; Semenogelase
other gene names :
KLK3; KLK3; APS; PSA; hK3; KLK2A1; APS
uniprot entry name :
KLK3_HUMAN
host :
PSA: Human seminal fluid. ACT: Human plasma
specificity :
Prostate Specific Antigen (PSA) ACT Complex >95% Pure
purity :
>95% pure (SDS PAGE)
concentration :
0.418mg/ml (Lowry with BSA standards)
storage stability :
Short-term (up to 3 weeks) store at 2 to 8 degree C. Long term store at -20 degree C. Avoid multiple freeze/thaw cycles.
other info1 :
Inactivation: Not applicable
other info2 :
Buffer: 10mM Sodium acetate, 0.15M Sodium chloride, pH 5.6. Preservative: 0.05% (w/v) Sodium azide. Dry Ice Shipment: Extra charge fee may add to your shipping cost as dry ice is required to ship this product. Warnings: This product contains sodium azide, which has been classified as Xn (Harmful), in European Directive 67/548/EEC in the concentration range of 0.1-1.0%. When disposing of this reagent through lead or copper plumbing, flush with copious volumes of water to prevent azide build-up in drains.
products categories :
Purified Reagents for Cancer Research
ncbi acc num :
NP_001639.1
ncbi gb acc num :
NM_001648.2
ncbi mol weight :
28,741 Da
ncbi pathways :
Coregulation Of Androgen Receptor Activity Pathway 138085!!Diabetes Pathways 105902!!FOXA1 Transcription Factor Network Pathway 137979!!Pathways In Cancer 83105!!Prostate Cancer Pathway 83111!!Prostate Cancer Pathway 523!!Regulation Of Androgen Receptor Activity Pathway 138027!!Regulation Of Insulin-like Growth Factor (IGF) Activity By Insulin-like Growth Factor Binding Proteins (IGFBPs) Pathway 105908
ncbi summary :
Kallikreins are a subgroup of serine proteases having diverse physiological functions. Growing evidence suggests that many kallikreins are implicated in carcinogenesis and some have potential as novel cancer and other disease biomarkers. This gene is one of the fifteen kallikrein subfamily members located in a cluster on chromosome 19. Its protein product is a protease present in seminal plasma. It is thought to function normally in the liquefaction of seminal coagulum, presumably by hydrolysis of the high molecular mass seminal vesicle protein. Serum level of this protein, called PSA in the clinical setting, is useful in the diagnosis and monitoring of prostatic carcinoma. Alternate splicing of this gene generates several transcript variants encoding different isoforms. [provided by RefSeq]
uniprot summary :
Function: Hydrolyzes semenogelin-1 thus leading to the liquefaction of the seminal coagulum. Catalytic activity: Preferential cleavage: -Tyr- -Xaa-. Enzyme regulation: Activity is strongly inhibited by Zn2+, 100 times more abundant in semen than in serum. This inhibition is relieved by exposure to semenogelins, which are avid zinc binders. Ref.18. Subcellular location: Secreted. Sequence similarities: Belongs to the peptidase S1 family. Kallikrein subfamily.Contains 1 peptidase S1 domain. Sequence caution: The sequence AAD14185.1 differs from that shown. Reason: Erroneous initiation.