Rabbit anti Laminin | MyBioSource MBS316319 product information

This webpage contains legacy information. The product is either no longer available from the supplier or has been delisted at Labome.

product summary

company name :

MyBioSource

product type :

antibody

product name :

Rabbit anti Laminin

catalog :

MBS316319

quantity :

0.5 mg

price :

1185 USD

clonality :

polyclonal

host :

rabbit

reactivity :

human

application :

western blot, ELISA, enzyme immunoassay

product information

catalog number :

MBS316319

products type :

Antibody

products full name :

Rabbit anti Laminin

products short name :

Laminin

products name syn :

Rabbit Antibody to Human Laminin

other names :

Laminin; Laminin, gamma 2; laminin subunit gamma-2; BM600-100kDa; nicein-100kDa; kalinin-105kDa; kalinin (105kD); ladsin (140kDa); nicein (100kDa); laminin B2t chain; OTTHUMP00000033550; OTTHUMP00000230852; CSF 140 kDa subunit; nicein subunit gamma; kalinin subunit gamma; ladsin 140 kDa subunit; epiligrin subunit gamma; laminin-5 subunit gamma; cell-scattering factor 140 kDa subunit; large adhesive scatter factor 140 kDa subunit; laminin, gamma 2

other gene names :

LAMC2; LAMC2; B2T; CSF; EBR2; BM600; EBR2A; LAMB2T; LAMNB2; MGC138491; MGC141938

uniprot entry name :

Q2M1N2_HUMAN

clonality :

Polyclonal

host :

Rabbit

reactivity :

Human

sequence length :

1111

specificity :

Laminin. Antibody reacts with most mammalian Laminins and has negligible cross-reactivity with Type I, II, III, IV, V and VI collagens and Fibronectin. Non-specific cross-reaction of anti Laminin antibodies with other human serum proteins or non-Laminin

purity :

Immunoaffinity chromatography using immobilized human placental laminin followed by extensive cross-adsorption against collagens, human serum proteins and non-collagen extracellular matrix proteins to remove any unwanted specificities. Typically less than

form :

Affinity Purified, Liquid

concentration :

1mg/ml (OD280nm)

storage stability :

Upon receipt, store at 2 to 8 degree C as an undiluted liquid. Prepare working dilution only prior to immediate use. For long term storage, mix with an equal volume of glycerol, aliquot and store at -20 degree C or below. Avoid multiple freeze/thaw cycles

tested application :

EIA/ELISA, Immunohistochemistry - Paraffin, Western Blot

other info1 :

Immunogen: Mixture of synthetic peptides corresponding to regions of adherence on laminin

other info2 :

Buffer: 0.125M Sodium Borate, 0.075M Sodium chloride, 0.005M EDTA; pH 8.0. Preservative: 0.01% Sodium Azide. Warnings: This product contains sodium azide, which has been classified as Xn (Harmful), in European Directive 67/548/EEC in the concentration range of 0.1 - 1.0 %. When disposing of this reagent through lead or copper plumbing, flush with copious volumes of water to prevent azide build-up in drains.

products categories :

Polyclonal Antibodies to Collagens and Extracellular Matrix Proteins

ncbi gi num :

34232

ncbi acc num :

CAA78729.1

uniprot acc num :

Q13753

ncbi mol weight :

121,634 Da

ncbi pathways :

Alpha6-Beta4 Integrin Signaling Pathway 198807!!Amoebiasis Pathway 167324!!Amoebiasis Pathway 167191!!Cell Junction Organization Pathway 160966!!ECM-receptor Interaction Pathway 83068!!ECM-receptor Interaction Pathway 479!!Focal Adhesion Pathway 198795!!Focal Adhesion Pathway 83067!!Focal Adhesion Pathway 478!!Inflammatory Response Pathway 198766

ncbi summary :

Laminins, a family of extracellular matrix glycoproteins, are the major noncollagenous constituent of basement membranes. They have been implicated in a wide variety of biological processes including cell adhesion, differentiation, migration, signaling, neurite outgrowth and metastasis. Laminins are composed of 3 non identical chains: laminin alpha, beta and gamma (formerly A, B1, and B2, respectively) and they form a cruciform structure consisting of 3 short arms, each formed by a different chain, and a long arm composed of all 3 chains. Each laminin chain is a multidomain protein encoded by a distinct gene. Several isoforms of each chain have been described. Different alpha, beta and gamma chain isomers combine to give rise to different heterotrimeric laminin isoforms which are designated by Arabic numerals in the order of their discovery, i.e. alpha1beta1gamma1 heterotrimer is laminin 1. The biological functions of the different chains and trimer molecules are largely unknown, but some of the chains have been shown to differ with respect to their tissue distribution, presumably reflecting diverse functions in vivo. This gene encodes the gamma chain isoform laminin, gamma 2. The gamma 2 chain, formerly thought to be a truncated version of beta chain (B2t), is highly homologous to the gamma 1 chain; however, it lacks domain VI, and domains V, IV and III are shorter. It is expressed in several fetal tissues but differently from gamma 1, and is specifically localized to epithelial cells in skin, lung and kidney. The gamma 2 chain together with alpha 3 and beta 3 chains constitute laminin 5 (earlier known as kalinin), which is an integral part of the anchoring filaments that connect epithelial cells to the underlying basement membrane. The epithelium-specific expression of the gamma 2 chain implied its role as an epithelium attachment molecule, and mutations in this gene have been associated with junctional epidermolysis bullosa, a skin disease characterized by blisters due to disruption of the epidermal-dermal junction. Two transcript variants resulting from alternative splicing of the 3' terminal exon, and encoding different isoforms of gamma 2 chain, have been described. The two variants are differentially expressed in embryonic tissues, however, the biological significance of the two forms is not known. Transcript variants utilizing alternative polyA_signal have also been noted in literature. [provided by RefSeq]

size :

0.5 mg

price :

1185 USD