Rabbit A' Mouse Laminin | MyBioSource MBS316309 product information

product summary

company name :

MyBioSource

product type :

antibody

product name :

Rabbit A' Mouse Laminin

catalog :

MBS316309

quantity :

0.5 ml

price :

720 USD

clonality :

polyclonal

host :

rabbit

conjugate :

nonconjugated

reactivity :

human, mouse

application :

ELISA, radioimmunoassay, enzyme immunoassay, immunohistochemistry - paraffin section

more info or order :

MyBioSource product webpage

product information

catalog number :

MBS316309

products type :

Antibody

products full name :

Rabbit A' Mouse Laminin

products short name :

Laminin

products name syn :

Rabbit A'Mouse Laminin; Rabbit Antibody to Mouse Laminin

other names :

Laminin; Laminin, gamma 2; laminin subunit gamma-2; BM600-100kDa; nicein-100kDa; kalinin-105kDa; kalinin (105kD); ladsin (140kDa); nicein (100kDa); laminin B2t chain; OTTHUMP00000033550; OTTHUMP00000230852; CSF 140 kDa subunit; nicein subunit gamma; kalinin subunit gamma; ladsin 140 kDa subunit; epiligrin subunit gamma; laminin-5 subunit gamma; cell-scattering factor 140 kDa subunit; large adhesive scatter factor 140 kDa subunit; laminin, gamma 2

other gene names :

LAMC2; LAMC2; B2T; CSF; EBR2; BM600; EBR2A; LAMB2T; LAMNB2; MGC138491; MGC141938

uniprot entry name :

Q2M1N2_HUMAN

clonality :

Polyclonal

host :

Rabbit

reactivity :

Mouse

sequence length :

1111

specificity :

Laminin. Crossreactivity: (RIA) %. Mouse Laminin - 100%. Mouse Fibronectin - <0.1%. Mouse Collagen type I - <0.1%. Mouse Collagen type II - <0.1%. Mouse Collagen type IV - <0.1%. Rat Collagen type I - <0.1%. Rat Collagen type III - <0.1%<b

purity :

Ion exchange chromatography (DEAE-Trisacryl)

form :

Purified, Lyophilized. Reconstitute with 0.5ml deionized water.

storage stability :

Lyophilized: Short-term (up to24 months) store at 2 to 8 degree C. Long term store at -20 degree C. Avoid multiple freeze/thaw cycles. Reconstituted: Store at -20 degree C. Aliquot to avoid freeze/thaw cycles.

tested application :

EIA/ELISA, Immunohistochemistry - Formalin/Paraffin, Radioimmunoassay

app notes :

ELISA (use diluted at >1:200). IFA (with fluorescein anti-rabbit IgG conjugate), use diluted at >1:80 on frozen mouse tissues. IHC (immunoperoxidase technique), use diluted at >1:500 on fixed, paraffin-embedded mouse tissues. Note: Limit tissue fixa

other info1 :

Immunogen: Mouse tumor tissues

other info2 :

Buffer: Not applicable. Preservative: No. Lyophilized: Yes. Important Note: Centrifuge before opening to ensure complete recovery of vial contents.

products categories :

Polyclonal Antibodies to Collagens and Extracellular Matrix Proteins

ncbi gi num :

34232

ncbi acc num :

CAA78729.1

uniprot acc num :

Q13753

ncbi mol weight :

121,634 Da

ncbi pathways :

Alpha6-Beta4 Integrin Signaling Pathway 198807!!Amoebiasis Pathway 167324!!Amoebiasis Pathway 167191!!Cell Junction Organization Pathway 160966!!ECM-receptor Interaction Pathway 83068!!ECM-receptor Interaction Pathway 479!!Focal Adhesion Pathway 198795!!Focal Adhesion Pathway 83067!!Focal Adhesion Pathway 478!!Inflammatory Response Pathway 198766

ncbi summary :

Laminins, a family of extracellular matrix glycoproteins, are the major noncollagenous constituent of basement membranes. They have been implicated in a wide variety of biological processes including cell adhesion, differentiation, migration, signaling, neurite outgrowth and metastasis. Laminins are composed of 3 non identical chains: laminin alpha, beta and gamma (formerly A, B1, and B2, respectively) and they form a cruciform structure consisting of 3 short arms, each formed by a different chain, and a long arm composed of all 3 chains. Each laminin chain is a multidomain protein encoded by a distinct gene. Several isoforms of each chain have been described. Different alpha, beta and gamma chain isomers combine to give rise to different heterotrimeric laminin isoforms which are designated by Arabic numerals in the order of their discovery, i.e. alpha1beta1gamma1 heterotrimer is laminin 1. The biological functions of the different chains and trimer molecules are largely unknown, but some of the chains have been shown to differ with respect to their tissue distribution, presumably reflecting diverse functions in vivo. This gene encodes the gamma chain isoform laminin, gamma 2. The gamma 2 chain, formerly thought to be a truncated version of beta chain (B2t), is highly homologous to the gamma 1 chain; however, it lacks domain VI, and domains V, IV and III are shorter. It is expressed in several fetal tissues but differently from gamma 1, and is specifically localized to epithelial cells in skin, lung and kidney. The gamma 2 chain together with alpha 3 and beta 3 chains constitute laminin 5 (earlier known as kalinin), which is an integral part of the anchoring filaments that connect epithelial cells to the underlying basement membrane. The epithelium-specific expression of the gamma 2 chain implied its role as an epithelium attachment molecule, and mutations in this gene have been associated with junctional epidermolysis bullosa, a skin disease characterized by blisters due to disruption of the epidermal-dermal junction. Two transcript variants resulting from alternative splicing of the 3' terminal exon, and encoding different isoforms of gamma 2 chain, have been described. The two variants are differentially expressed in embryonic tissues, however, the biological significance of the two forms is not known. Transcript variants utilizing alternative polyA_signal have also been noted in literature. [provided by RefSeq]

size :

0.5 ml

price :

720 USD

more info or order :

MyBioSource product webpage