MyBioSource

antibody

Rabbit anti eNOS

MBS316207

0.1 ml

390 USD

polyclonal

rabbit

human

MBS316207

Antibody

Rabbit anti eNOS

Nitric Oxide Synthase, Endothelial (eNOS) (a.a. 2-11)

Rabbit Antibody to Human Endothelial Nitric Oxide Synthase (eNOS)

Nitric oxide synthase, endothelial; Nitric oxide synthase, endothelial; nitric oxide synthase, endothelial; cNOS; EC-NOS; NOSIII; NOS type III; endothelial NOS; constitutive NOS; OTTHUMP00000212826; OTTHUMP00000213183; OTTHUMP00000213184; OTTHUMP00000213185; nitric oxide synthase 3 (endothelial cell); Constitutive NOS; cNOS; EC-NOS; Endothelial NOS; eNOS; NOS type III

NOS3; NOS3; eNOS; ECNOS; N/A

NOS3_HUMAN

Polyclonal

Rabbit

1203

Nitric Oxide Synthase, Endothelial (eNOS) (a.a. 2-11). Recognizes Human Endothelial Nitric Oxide Synthase (eNOS). Specific for the amino terminal of eNOS. It recognizes the non-myrisylated form best, but does cross-react ~50% with the myristylated form

Neat, Lyophilized. Reconstitute with 0.1ml PBS containing 10mg/ml BSA or with additional buffer for more dilute antibody.

Store lyophilized product at 2 to 8 degree C (preferably in a dessicator). After reconstitution, aliquot and store at -20 degree C.

Immunogen: eNOS (2-11 Cys^12) covalently attached to a carrier protein.

Buffer: Not applicable. Preservative: No. Lyophilized: Yes

Polyclonal Antibodies for Neuroscience

266648

P29474.3

P29474

133,289 Da

ACE Inhibitor Pathway 198763!!Angiopoietin Receptor Tie2-mediated Signaling Pathway 137917!!Arginine And Proline Metabolism Pathway 82957!!Arginine And Proline Metabolism Pathway 323!!Calcium Signaling Pathway 83050!!Calcium Signaling Pathway 459!!Formation Of Platelet Plug Pathway 106029!!Hemostasis Pathway 106028!!Metabolic Pathways 132956!!Metabolism Of Nitric Oxide Pathway 106222

Nitric oxide is a reactive free radical which acts as a biologic mediator in several processes, including neurotransmission and antimicrobial and antitumoral activities. Nitric oxide is synthesized from L-arginine by nitric oxide synthases. Variations in this gene are associated with susceptibility to coronary spasm. Multiple transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq]

Function: Produces nitric oxide (NO) which is implicated in vascular smooth muscle relaxation through a cGMP-mediated signal transduction pathway. NO mediates vascular endothelial growth factor (VEGF)-induced angiogenesis in coronary vessels and promotes blood clotting through the activation of platelets. Catalytic activity: L-arginine + n NADPH + n H+ + m O2 = citrulline + nitric oxide + n NADP+. Cofactor: Heme group.Binds 1 FAD.Binds 1 FMN.Tetrahydrobiopterin (BH4). May stabilize the dimeric form of the enzyme. Enzyme regulation: Stimulated by calcium/calmodulin. Inhibited by NOSIP and NOSTRIN. Ref.19 Ref.20. Subunit structure: Homodimer. Interacts with NOSIP and NOSTRIN. Ref.19 Ref.20. Subcellular location: Cell membrane. Membrane caveola. Cytoplasm cytoskeleton. Golgi apparatus. Note: Specifically associates with actin cytoskeleton in the G2 phase of the cell cycle; which is favored by interaction with NOSIP and results in a reduced enzymatic activity. Ref.19 Ref.20 Ref.21 Ref.22. Tissue specificity: Platelets, placenta, liver and kidney. Ref.18. Polymorphism: Variation in NOS3 seem to be associated with susceptibility to coronary spasm. Sequence similarities: Belongs to the NOS family.Contains 1 FAD-binding FR-type domain.Contains 1 flavodoxin-like domain.

0.1 ml

390 USD