antibody

Rabbit anti D4 Dopamine Recept

MBS316188

0.1 ml

970 USD

polyclonal

rabbit

nonconjugated

western blot, ELISA, immunohistochemistry, enzyme immunoassay

Antibody

Rabbit anti D4 Dopamine Recept

Dopamine D4 Receptor (a.a. 176-185)

Rabbit anti Dopamine D4 Recept; Rabbit Antibody to Dopamine D4 Receptor (amino acids 176-185)

dopamine D4 receptor; D(4) dopamine receptor; D(4) dopamine receptor; D(4) dopamine receptor; OTTHUMP00000164435; dopamine D4 receptor; D(2C) dopamine receptor; seven transmembrane helix receptor; dopamine receptor D4; D(2C) dopamine receptor; Dopamine D4 receptor

DRD4; DRD4; D4DR

DRD4_HUMAN

Polyclonal

Rabbit

Dopamine D4 Receptor (a.a. 176-185). Specific for Dopamine D4 Receptor (a.a. 176-185). This antisera has been characterized for immunocytochemical, Western blot and ELISA techniques. Crossreactivity: D4 Dopamine Receptor (Ac-176-185) - 100%. D4 Dop

Precipitation, dialysis and chromatography

Purified, Lyophilized. Reconstitute with 0.1 ml of PBS which contains 10mg/ml BSA or with additional buffer for more dilute antibody.

17.7mg/ml (prior to lyophilization)

Lyophilized: Store at 2 to 8 degree C (preferably in a dessicator). Reconstituted: Aliquot and store at -20 degree C.

EIA/ELISA, Immunohistochemistry, Western Blot

Immunogen: D4(Ac-176-185) covalently attached onto a carrier protein.

Buffer: Lyophilized from 0.1M ammonium bicarbonate. Preservative: No. Lyophilized: Yes

Polyclonal Antibodies for Neuroscience

1835973

P21917

48,361 Da

Amine Ligand-binding Receptors Pathway 106363!!Class A/1 (Rhodopsin-like Receptors) Pathway 106357!!Dopamine Receptors Pathway 106366!!G Alpha (i) Signalling Events Pathway 119550!!GPCR Downstream Signaling Pathway 119548!!GPCR Ligand Binding Pathway 161020!!GPCRs, Class A Rhodopsin-like Pathway 198886!!GPCRs, Other Pathway 198765!!Hypothetical Network For Drug Addiction Pathway 198776!!Monoamine GPCRs Pathway 198861

This gene encodes the D4 subtype of the dopamine receptor. The D4 subtype is a G-protein coupled receptor which inhibits adenylyl cyclase. It is a target for drugs which treat schizophrenia and Parkinson disease. Mutations in this gene have been associated with various behavioral phenotypes, including autonomic nervous system dysfunction, attention deficit/hyperactivity disorder, and the personality trait of novelty seeking. This gene contains a polymorphic number (2-10 copies) of tandem 48 nt repeats; the sequence shown contains four repeats. [provided by RefSeq]

Function: This is one of the five types (D1 to D5) of receptors for dopamine. The activity of this receptor is mediated by G proteins which inhibit adenylyl cyclase. Subunit structure: Interacts with CLIC6. By similarity and GPRASP1. Ref.9. Subcellular location: Cell membrane; Multi-pass membrane protein. Polymorphism: The number of repeats of 16 amino acids in the third cytoplasmic loop is highly polymorphic and varies among different alleles. Alleles corresponding in size to a 2 (D4.2), 3 (D4.3), 4 (D4.4), 5 (D4.5), 6 (D4.6), 7 (D4.7) and 9 (D4.9) repeats have been described. The sequence shown is that of allele D4.7. The polymorphic repeat sequence has little influence on DRD4-binding profiles and might not be essential for G protein interaction. Sequence similarities: Belongs to the G-protein coupled receptor 1 family. Sequence caution: The sequence AAL58637.1 differs from that shown. Reason: Erroneous gene model prediction.

0.1 ml

970 USD