antibody

Rabbit anti iNOS

MBS316167

0.1 mL

390 USD

polyclonal

rabbit

nonconjugated

western blot, immunocytochemistry

Antibody

Rabbit anti iNOS

Nitric Oxide Synthase, Inducible (iNOS) (a.a. 1137-1153)

Rabbit Antibody to Human Inducible Nitric Oxide Synthase (iNOS)

Nitric oxide synthase, inducible; Nitric oxide synthase, inducible; nitric oxide synthase, inducible; NOS type II; NOS, type II; inducible NOS; hepatocyte NOS; OTTHUMP00000163279; inducible NO synthase; nitric oxide synthase, macrophage; peptidyl-cysteine S-nitrosylase NOS2; nitric oxide synthase 2A (inducible, hepatocytes); nitric oxide synthase 2, inducible; Hepatocyte NOS; HEP-NOS; Inducible NO synthase; Inducible NOS; iNOS; NOS type II; Peptidyl-cysteine S-nitrosylase NOS2

NOS2; NOS2; NOS; INOS; NOS2A; HEP-NOS; NOS2A

NOS2_HUMAN

Polyclonal

Rabbit

1153

Nitric Oxide Synthase, Inducible (iNOS) (a.a. 1137-1153). Recognizes Human Inducible Nitric Oxide Synthase (iNOS). Specific for the carboxyl end of hiNOS. Characterized by western blotting, ELISA, and cell staining techniques using synthetic peptides an

Neat, Lyophilized. Reconstitute with 0.1ml PBS containing 10mg/ml BSA or with additional buffer for more dilute antiserum.

Lyophilized: Store at 2 to 8 degree C (preferably in a dessicator). Reconstituted: Aliquot and store at -20 degree C.

Immunofluorescence Assay, Immunohistochemistry - Formalin, Western Blot

Immunogen: human iNOS(Cys^1137-1138-1153) covalently attached to a carrier protein

Buffer: Not applicable. Preservative: No. Lyophilized: Yes. Important Note: Centrifuge before opening to ensure complete recovery of vial contents.

Polyclonal Antibodies for Neuroscience

1352513

P35228.2

P35228

131,117 Da

ATF-2 Transcription Factor Network Pathway (138006); Amoebiasis Pathway (167324); Amoebiasis Pathway (167191); Arginine And Proline Metabolism Pathway (82957); Arginine And Proline Metabolism Pathway (323); Calcium Signaling Pathway (83050); Calcium Signaling Pathway (459); Chagas Disease (American Trypanosomiasis) Pathway (147809); Chagas Disease (American Trypanosomiasis) Pathway (147795); Formation Of Platelet Plug Pathway (106029)

Nitric oxide is a reactive free radical which acts as a biologic mediator in several processes, including neurotransmission and antimicrobial and antitumoral activities. This gene encodes a nitric oxide synthase which is expressed in liver and is inducible by a combination of lipopolysaccharide and certain cytokines. Three related pseudogenes are located within the Smith-Magenis syndrome region on chromosome 17. [provided by RefSeq]

Function: Produces nitric oxide (NO) which is a messenger molecule with diverse functions throughout the body. In macrophages, NO mediates tumoricidal and bactericidal actions. Also has nitrosylase activity and mediates cysteine S-nitrosylation of cytoplasmic target proteins such COX2. Catalytic activity: L-arginine + n NADPH + n H+ + m O2 = citrulline + nitric oxide + n NADP+. Cofactor: Heme group. By similarity.Binds 1 FAD. By similarity.Binds 1 FMN. By similarity.Tetrahydrobiopterin (BH4). May stabilize the dimeric form of the enzyme. Enzyme regulation: Regulated by calcium/calmodulin. Aspirin inhibits expression and function of this enzyme and effects may be exerted at the level of translational/post-translational modification and directly on the catalytic activity. Subunit structure: Homodimer. Binds SLC9A3R1. Tissue specificity: Expressed in the liver, retina, bone cells and airway epithelial cells of the lung. Not expressed in the platelets. Induction: By endotoxins and cytokines. Induced by IFNG/IFN-gamma acting synergistically with bacterial lipopolysaccharides (LPS), TNF or IL1B/interleukin-1 beta. Ref.14. Sequence similarities: Belongs to the NOS family.Contains 1 FAD-binding FR-type domain.Contains 1 flavodoxin-like domain.

0.1 mL

390 USD