Goat anti UCH-L1 N-terminal | MyBioSource MBS316157 product information

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product summary

company name :

MyBioSource

product type :

antibody

product name :

Goat anti UCH-L1 N-terminal

catalog :

MBS316157

quantity :

1 ml

price :

880 USD

clonality :

polyclonal

host :

goat

reactivity :

human

application :

western blot, ELISA, enzyme immunoassay

product information

catalog number :

MBS316157

products type :

Antibody

products full name :

Goat anti UCH-L1 N-terminal

products short name :

Ubiquitin Carboxyl-terminal Hydrolase L1 (UCH-L1) N-terminal

products name syn :

Goat Antibody to Human Ubiquitin Carboxy-terminal Hydrolase L1 (UCH-L1), N-Terminal

other names :

Ubiquitin carboxyl-terminal hydrolase isozyme L1; Ubiquitin carboxyl-terminal hydrolase isozyme L1; ubiquitin carboxyl-terminal hydrolase isozyme L1; OTTHUMP00000125219; OTTHUMP00000218137; OTTHUMP00000218139; OTTHUMP00000218140; OTTHUMP00000218141; ubiquitin thioesterase L1; neuron cytoplasmic protein 9.5; ubiquitin C-terminal hydrolase; ubiquitin carboxyl-terminal esterase L1 (ubiquitin thiolesterase); Neuron cytoplasmic protein 9.5; PGP 9.5; PGP9.5; Ubiquitin thioesterase L1

other gene names :

UCHL1; UCHL1; PARK5; PGP95; PGP9.5; Uch-L1; PGP 9.5

uniprot entry name :

UCHL1_HUMAN

clonality :

Polyclonal

host :

Goat

sequence length :

223

specificity :

Ubiquitin Carboxyl-terminal Hydrolase L1 (UCH-L1) N-terminal. N-terminal amino acid sequence 46-63 of human Ubiquitin Carboxy-Terminal Hydrolase L1 protein.

form :

Neat, Liquid

storage stability :

Short-term store at 2 to 8 degree C. Long term store at -20 degree C.

tested application :

EIA/ELISA, Western Blot

app notes :

ELISA using immunizing peptide (>=1:71,350). Western blot (>=1:2,000). Suitability for use in IHC using paraformaldehyde-fixed, frozen sections and formalin-fixed, paraffin-embedded sections has not been determined but use in such assays should not ne

other info1 :

Immunogen: Peptide (NFRKKQIEELKGQEVSPK)

other info2 :

Buffer: Not applicable. Preservative: 0.1% Sodium Azide. Warnings: This product contains sodium azide, which has been classified as Xn (Harmful), in European Directive 67/548/EEC in the concentration range of 0.1 - 1.0 %. When disposing of this reagent through lead or copper plumbing, flush with copious volumes of water to prevent azide build-up in drains.

products categories :

Polyclonal Antibodies for Neuroscience

ncbi gi num :

136681

ncbi acc num :

P09936.2

uniprot acc num :

P09936

ncbi mol weight :

24,824 Da

ncbi pathways :

Alpha-synuclein Signaling Pathway 137913!!Parkinson's Disease Pathway 83098

ncbi summary :

The protein encoded by this gene belongs to the peptidase C12 family. This enzyme is a thiol protease that hydrolyzes a peptide bond at the C-terminal glycine of ubiquitin. This gene is specifically expressed in the neurons and in cells of the diffuse neuroendocrine system. Mutations in this gene may be associated with Parkinson disease.

uniprot summary :

Function: Ubiquitin-protein hydrolase involved both in the processing of ubiquitin precursors and of ubiquitinated proteins. This enzyme is a thiol protease that recognizes and hydrolyzes a peptide bond at the C-terminal glycine of ubiquitin. Also binds to free monoubiquitin and may prevent its degradation in lysosomes. The homodimer may have ATP-independent ubiquitin ligase activity. Ref.12 Ref.13 Ref.27. Catalytic activity: Thiol-dependent hydrolysis of ester, thioester, amide, peptide and isopeptide bonds formed by the C-terminal Gly of ubiquitin (a 76-residue protein attached to proteins as an intracellular targeting signal). Ref.19. Subunit structure: Monomer. Homodimer. Interacts with SNCA. By similarity. Interacts with COPS5. Ref.14 Ref.18. Subcellular location: Cytoplasm. Tissue specificity: Found in neuronal cell bodies and processes throughout the neocortex (at protein level). Expressed in neurons and cells of the diffuse neuroendocrine system and their tumors. Weakly expressed in ovary. Down-regulated in brains from Parkinson disease and Alzheimer disease patients. Ref.5 Ref.12. Post-translational modification: O-glycosylated. Involvement in disease: Defects in UCHL1 are the cause of Parkinson disease type 5 (PARK5) [. MIM:613643]; also known as Parkinson disease autosomal dominant 5. PARK5 is a complex neurodegenerative disorder with manifestations ranging from typical Parkinson disease to dementia with Lewy bodies. Clinical features include parkinsonian symptoms (resting tremor, rigidity, postural instability and bradykinesia), dementia, diffuse Lewy body pathology, autonomic dysfunction, hallucinations and paranoia. Ref.8 Ref.13 Ref.20 Ref.26. Miscellaneous: Oxidation of Met-1, Met-6, Met-12, Met-124 and Met-179 to methionine sulfoxide, and oxidation of Cys-220 to cysteine sulfonic acid have been observed in brains from Alzheimer disease (AD) and Parkinson disease (PD) patients. In AD, UCHL1 was found to be associated with neurofibrillary tangles. In contrast to UCHL3, does not hydrolyze a peptide bond at the C-terminal glycine of NEDD8. Sequence similarities: Belongs to the peptidase C12 family. Caution: Ref.8 reports the association of mutation Ile93Met with Parkinson disease. However, according to Ref.26 this association is uncertain and UCHL1 is not a susceptibility gene for Parkinson disease. Biophysicochemical propertiesKinetic parameters:KM=122 nM for Ub-AMC Ref.8 Ref.11 Ref.20KM=1.20 uM for ubiquitin ethyl esterVmax=0.47 umol/min/mg enzyme toward Ub-AMCVmax=25 umol/min/mg enzyme toward ubiquitin ethyl ester. Sequence caution: The sequence CAA28443.1 differs from that shown. Reason: Erroneous initiation. Translation N-terminally extended.

size :

1 ml

price :

880 USD