MyBioSource

antibody

Goat A' Alpha 2 Macroglobulin

MBS316071

10 ml

175 USD

polyclonal

goat

human

MBS316071

Antibody

Goat A' Alpha 2 Macroglobulin

Alpha 2 Macroglobulin

Goat Antibody to Human Alpha 2 Macroglobulin

Alpha-2-macroglobulin; Alpha-2-macroglobulin; alpha-2-macroglobulin; alpha-2-M; OTTHUMP00000196829; C3 and PZP-like alpha-2-macroglobulin domain-containing protein 5; alpha-2-macroglobulin; C3 and PZP-like alpha-2-macroglobulin domain-containing protein 5

A2M; A2M; A2MD; CPAMD5; FWP007; S863-7; DKFZp779B086; CPAMD5

A2MG_HUMAN

Polyclonal

Goat

1474

Alpha 2 Macroglobulin. Monospecific by immunoelectrophoresis versus 1X pooled human plasma and 2X concentrated normal human serum

Defribinated, delipidized and absorbed by solid phase chromatography. Product is 0.2uum filtered.

Monospecific, Liquid

Total protein: 6.8g/dL

Short-term store at 2 to 8 degree C. Long term store at -20 degree C. Avoid multiple freeze/thaw cycles.

IEP

Immunogen: Purified Human Alpha 2 Macroglobulin

Buffer: 0.05M Tris-HCl, 0.5M Sodium chloride, pH 7.5. Preservative: 0.09% Sodium azide. Important Note: Centrifuge before opening to ensure complete recovery of vial contents. Warnings: This product contains sodium azide, which has been classified as Xn (Harmful), in European Directive 67/548/EEC in the concentration range of 0.1-1.0 %. When disposing of this reagent through lead or copper plumbing, flush with copious volumes of water to prevent azide build-up in drains.

Polyclonal Antibodies to Proteins and Bioactive Peptides

112911

P01023.1

P01023

163,291 Da

Complement And Coagulation Cascades Pathway 198880!!Complement And Coagulation Cascades Pathway 83073!!Complement And Coagulation Cascades Pathway 484!!Formation Of Fibrin Clot (Clotting Cascade) Pathway 106057!!Formation Of Platelet Plug Pathway 106029!!HDL-mediated Lipid Transport Pathway 106158!!Hemostasis Pathway 106028!!IL6-mediated Signaling Events Pathway 137932!!Intrinsic Pathway 106059!!Lipid Digestion, Mobilization, And Transport Pathway 106111

Alpha-2-macroglobulin is a protease inhibitor and cytokine transporter. It inhibits many proteases, including trypsin, thrombin and collagenase. A2M is implicated in Alzheimer disease (AD) due to its ability to mediate the clearance and degradation of A-beta, the major component of beta-amyloid deposits. [provided by RefSeq]

Function: Is able to inhibit all four classes of proteinases by a unique 'trapping' mechanism. This protein has a peptide stretch, called the 'bait region' which contains specific cleavage sites for different proteinases. When a proteinase cleaves the bait region, a conformational change is induced in the protein which traps the proteinase. The entrapped enzyme remains active against low molecular weight substrates (activity against high molecular weight substrates is greatly reduced). Following cleavage in the bait region a thioester bond is hydrolyzed and mediates the covalent binding of the protein to the proteinase. Subunit structure: Homotetramer; disulfide-linked. Ref.8 Ref.10. Subcellular location: Secreted Ref.8. Tissue specificity: Secreted in plasma. Ref.8. Developmental stage: Contrary to the rat protein, which is an acute phase protein, this protein is always present at high levels in circulation. Sequence similarities: Belongs to the protease inhibitor I39 (alpha-2-macroglobulin) family. [View classification]. Sequence caution: The sequence AAT02228.1 differs from that shown. Reason: Erroneous initiation. Translation N-terminally shortened.The sequence BAD92851.1 differs from that shown. Reason: Erroneous initiation. Translation N-terminally shortened.

10 ml

175 USD