Sheep anti Antithrombin III | MyBioSource MBS315989 product information

product summary

company name :

MyBioSource

product type :

antibody

product name :

Sheep anti Antithrombin III

catalog :

MBS315989

quantity :

1 ml

price :

315 USD

clonality :

polyclonal

host :

sheep

conjugate :

nonconjugated

reactivity :

human

more info or order :

MyBioSource product webpage

product information

catalog number :

MBS315989

products type :

Antibody

products full name :

Sheep anti Antithrombin III

products short name :

Antithrombin III

products name syn :

Sheep Antibody to Human Antithrombin III

other names :

antithrombin III; Antithrombin-III; antithrombin-III; serpin C1; antithrombin III; OTTHUMP00000035393; serine-cysteine proteinase inhibitor clade C member 1; serine (or cysteine) proteinase inhibitor, clade C (antithrombin), member 1; serpin peptidase inhibitor, clade C (antithrombin), member 1; Serpin C1

other gene names :

SERPINC1; SERPINC1; AT3; ATIII; MGC22579; AT3

uniprot entry name :

ANT3_HUMAN

clonality :

Polyclonal

host :

Sheep

sequence length :

464

specificity :

Antithrombin III. Antithrombin III (ATH III) is a plasma protein synthesized in the liver. Normal plasma levels are 115-160mg/L. ATH III consists of a single polypeptide chain and has a molecular weight of 58kDa. ATH III is a serine protease inhibitor a

purity :

Antiserum is delipidated and if necessary adsorbed to monospecificity by use of solid-phase adsorbants. Following adsorption an immunoglobulin fraction is produced by ion-exchange chromatography (DEAE). Monospecificity is confirmed by immunoelectrophoresi

form :

Purified, Liquid

concentration :

11.0mg/ml (OD280nm, E^1% = 14.5)

storage stability :

Store at 2 to 8 degree C. Slight precipitation can occur upon storage that can be removed by centrifugation and should not affect performance characteristics.

other info1 :

Immunogen: Human antithrombin III purified from plasma, shown to be homogeneous by SDS-PAGE.

other info2 :

Buffer: Glycine buffered saline, pH 7.4. Preservative: 0.099% Sodium azide, 0.1% EACA, 0.01% Benzamidine, 1mM EDTA. Important Note: Centrifuge before opening to ensure complete recovery of vial contents. Warnings: This product contains sodium azide, which has been classified as Xn (Harmful), in European Directive 67/548/EEC in the concentration range of 0.1-1.0 %. When disposing of this reagent through lead or copper plumbing, flush with copious volumes of water to prevent azide build-up in drains.

products categories :

Polyclonal Antibodies to Platelets and Hemostasis Antigens

ncbi gi num :

179130

ncbi acc num :

AAB40025.1

uniprot acc num :

P01008

ncbi mol weight :

52,602 Da

ncbi pathways :

Common Pathway 106060!!Complement And Coagulation Cascades Pathway 198880!!Complement And Coagulation Cascades Pathway 83073!!Complement And Coagulation Cascades Pathway 484!!Formation Of Fibrin Clot (Clotting Cascade) Pathway 106057!!Glypican 1 Network Pathway 138010!!Hemostasis Pathway 106028

ncbi summary :

The protein encoded by this gene is a plasma protease inhibitor and a member of the serpin superfamily. This protein inhibits thrombin as well as other activated serine proteases of the coagulation system, and it regulates the blood coagulation cascade. The protein includes two functional domains: the heparin binding-domain at the N-terminus of the mature protein, and the reactive site domain at the C-terminus. The inhibitory activity is enhanced by the presence of heparin. More than 120 mutations have been identified for this gene, many of which are known to cause antithrombin-III deficiency. [provided by RefSeq]

uniprot summary :

Function: Most important serine protease inhibitor in plasma that regulates the blood coagulation cascade. AT-III inhibits thrombin as well as factors IXa, Xa and XIa. Its inhibitory activity is greatly enhanced in the presence of heparin. Subcellular location: Secreted extracellular space. Tissue specificity: Found in plasma. Ref.21. Post-translational modification: Phosphorylation sites are present in the extracelllular medium. Involvement in disease: Defects in SERPINC1 are the cause of antithrombin III deficiency (AT3D) [. MIM:613118]. AT3D is an important risk factor for hereditary thrombophilia, a hemostatic disorder characterized by a tendency to recurrent thrombosis. AT3D is classified into 4 types. Type I: characterized by a 50% decrease in antigenic and functional levels. Type II: has defects affecting the thrombin-binding domain. Type III: alteration of the heparin-binding domain. Plasma AT-III antigen levels are normal in type II and III. Type IV: consists of miscellaneous group of unclassifiable mutations. Ref.3 Ref.12 Ref.13 Ref.31 Ref.32 Ref.33 Ref.34 Ref.35 Ref.36 Ref.37 Ref.38 Ref.40 Ref.41 Ref.42 Ref.43 Ref.44 Ref.45 Ref.46 Ref.47 Ref.48 Ref.49 Ref.50 Ref.51 Ref.52 Ref.53 Ref.54 Ref.55 Ref.56 Ref.57 Ref.59 Ref.60 Ref.61 Ref.62 Ref.63 Ref.64 Ref.65 Ref.66. Sequence similarities: Belongs to the serpin family. Mass spectrometry: Molecular mass is 57863 Da from positions 33 - 464. Determined by ESI. Ref.13Molecular mass is 57911 Da from positions 33 - 464. Determined by ESI. Variant Thr-414. Ref.13

size :

1 ml

price :

315 USD

more info or order :

MyBioSource product webpage