Rabbit anti GAPDH, N-term. | MyBioSource MBS315963 product information

This webpage contains legacy information. The product is either no longer available from the supplier or has been delisted at Labome.

product summary

company name :

MyBioSource

product type :

antibody

product name :

Rabbit anti GAPDH, N-term.

catalog :

MBS315963

quantity :

0.1 mg

price :

660 USD

clonality :

polyclonal

host :

rabbit

reactivity :

human

application :

western blot

product information

catalog number :

MBS315963

products type :

Antibody

products full name :

Rabbit anti GAPDH, N-term.

products short name :

Glyceraldehyde-3-Phosphate Dehydrogenase (GAPDH) N-terminal

products name syn :

Rabbit Antibody to Human Glyceraldehyde-3-phosphate Dehydrogenase (GAPDH), N-terminal

other names :

glyceraldehyde-3-phosphate dehydrogenase; Glyceraldehyde-3-phosphate dehydrogenase; glyceraldehyde-3-phosphate dehydrogenase; OTTHUMP00000174430; OTTHUMP00000174431; OTTHUMP00000174432; OTTHUMP00000174434; aging-associated gene 9 protein; peptidyl-cysteine S-nitrosylase GAPDH; glyceraldehyde 3-phosphate dehydrogenase; glyceraldehyde-3-phosphate dehydrogenase; Peptidyl-cysteine S-nitrosylase GAPDH

other gene names :

GAPDH; GAPDH; G3PD; GAPD; MGC88685; GAPD

uniprot entry name :

G3P_HUMAN

clonality :

Polyclonal

host :

Rabbit

reactivity :

Human

sequence length :

335

specificity :

Glyceraldehyde-3-Phosphate Dehydrogenase (GAPDH) N-terminal. Reacts with human, mouse and rat GAPDH.

purity :

Immunoaffinity chromatography

form :

Affinity Purified, Liquid

concentration :

1mg/ml

storage stability :

Store (up to one year) at 2 to 8 degree C.

tested application :

Western Blot

other info1 :

Immunogen: Synthetic peptide corresponding to 16 amino acids near the amino terminus of human GAPDH. (Genbank accession No. P04406)

other info2 :

Buffer: PBS. Preservative: 0.02% Sodium azide. Important Note: Centrifuge before opening to ensure complete recovery of vial contents. Warnings: This product contains sodium azide, which has been classified as Xn (Harmful), in European Directive 67/548/EEC in the concentration range of 0.1 - 1.0 %. When disposing of this reagent through lead or copper plumbing, flush with copious volumes of water to prevent azide build-up in drains.

products categories :

Polyclonal Antibodies to Enzymes

products references :

Sirover, M.A., et al., (2005), "New nuclear functions of the glycolytic protein, glyceraldehyde-3-phosphate dehydrogenase, in mammalian cells", J. Cell. Biochem., 95: 45-52. Chuang, D.M., et al., (2005),. "Glyceraldehyde-3-phosph

ncbi gi num :

7669492

ncbi acc num :

NP_002037.2

ncbi gb acc num :

NM_002046.3

uniprot acc num :

P04406

ncbi mol weight :

36,053 Da

ncbi pathways :

Alzheimer's Disease Pathway 83097!!Alzheimer's Disease Pathway 509!!Androgen Receptor Signaling Pathway 198806!!Gluconeogenesis Pathway 106204!!Glucose Metabolism Pathway 106199!!Glycolysis Pathway 105911!!Glycolysis / Gluconeogenesis Pathway 82926!!Glycolysis / Gluconeogenesis Pathway 287!!Metabolic Pathways 132956!!Metabolism Of Carbohydrates Pathway 106196

ncbi summary :

The product of this gene catalyzes an important energy-yielding step in carbohydrate metabolism, the reversible oxidative phosphorylation of glyceraldehyde-3-phosphate in the presence of inorganic phosphate and nicotinamide adenine dinucleotide (NAD). The enzyme exists as a tetramer of identical chains. Many pseudogenes similar to this locus are present in the human genome. [provided by RefSeq]

uniprot summary :

Function: Has both glyceraldehyde-3-phosphate dehydrogenase and nitrosylase activities, thereby playing a role in glycolysis and nuclear functions, respectively. Participates in nuclear events including transcription, RNA transport, DNA replication and apoptosis. Nuclear functions are probably due to the nitrosylase activity that mediates cysteine S-nitrosylation of nuclear target proteins such as SIRT1, HDAC2 and PRKDC. By similarity. Glyceraldehyde-3-phosphate dehydrogenase is a key enzyme in glycolysis that catalyzes the first step of the pathway by converting D-glyceraldehyde 3-phosphate (G3P) into 3-phospho-D-glyceroyl phosphate. Ref.6 Ref.23. Catalytic activity: D-glyceraldehyde 3-phosphate + phosphate + NAD+ = 3-phospho-D-glyceroyl phosphate + NADH. Ref.6. Pathway: Carbohydrate degradation; glycolysis; pyruvate from D-glyceraldehyde 3-phosphate: step 1/5. Subunit structure: Homotetramer. Interacts with TPPP; the interaction is direct. Interacts (when S-nitrosylated) with SIAH1; leading to nuclear translocation. Interacts with RILPL1/GOSPEL, leading to prevent the interaction between GAPDH and SIAH1 and prevent nuclear translocation. By similarity. Interacts with EIF1AD, USP25, PRKCI and WARS. Ref.23 Ref.25 Ref.28 Ref.36 Ref.39 Ref.40. Subcellular location: Cytoplasm cytosol. Nucleus. By similarity. Cytoplasm perinuclear region. Membrane. Note: Translocates to the nucleus following S-nitrosylation and interaction with SIAH1, which contains a nuclear localization signal. By similarity. Postnuclear and Perinuclear regions. Ref.24. Post-translational modification: S-nitrosylation of Cys-152 leads to interaction with SIAH1, followed by translocation to the nucleus. By similarity.ISGylated. Probable. Ref.29. Sequence similarities: Belongs to the glyceraldehyde-3-phosphate dehydrogenase family.

size :

0.1 mg

price :

660 USD