antibody

Goat anti Apo CIII

MBS315850

1 ml

600 USD

polyclonal

goat

nonconjugated

western blot, ELISA, enzyme immunoassay

Antibody

Goat anti Apo CIII

Apolipoprotein CIII (Apo CIII)

Goat Antibody to Human Apolipoprotein CIII (Apo CIII)

apolipoprotein C-III; Apolipoprotein C-III; apolipoprotein C-III; apo-CIII; apoC-III; apolipoprotein C3; OTTHUMP00000043270; OTTHUMP00000069353; apolipoprotein C-III; Apolipoprotein C3

APOC3; APOC3; APOCIII; MGC150353

APOC3_HUMAN

Polyclonal

Goat

Human

99

Apolipoprotein CIII (Apo CIII). Binds to Human Apo CIII

Immunoaffinity chromatography using Human Apo CIII-Sepharose affinity column followed by conjugation with HRP

HRP, Lyophilized. Reconstitute with 1ml distilled water. Centrifuge the product if not completely clear after standing for 1-2 hours at room temperature.

1.5mg/ml (prior to lyophilization)

Store lyophilized product at 2 to 8 degree C. After reconstitution, product is stable for several weeks stored at 2 to 8 degree C as an undiluted liquid. Prepare working dilution only prior to immediate use. For extended storage after reconstitution, we s

EIA/ELISA, Western Blot

Immunogen: Purified human Apolipoprotein CIII

Buffer: 50mM PBS, pH 7.4 containing 0.1M Sodium chloride and 10mg/ml BSA. Preservative: 0.01% Thimerosal. Lyophilized: Yes. Important Note: Centrifuge before opening to ensure complete recovery of vial contents. Warnings: Use of sodium azide as a preservative will substantially inhibit the enzyme activity of horseradish peroxidase.

Polyclonal Antibodies to Lipoproteins

Harwood, H.J., et al., (2003), "Isozyme-nonselective N-Substituted Bipiperidylcarboxamide Acetyl-CoA Carboxylase Inhibitors Reduce Tissue Malonyl-CoA Concentrations, Inhibit Fatty Acid Synthesis, and Increase Fatty Acid Oxidation in Cultured C

4557323

NP_000031.1

NM_000040.1

P02656

10,852 Da

Chylomicron-mediated Lipid Transport Pathway 106157!!HDL-mediated Lipid Transport Pathway 106158!!Lipid Digestion, Mobilization, And Transport Pathway 106111!!Lipoprotein Metabolism Pathway 106156!!Metabolism Of Lipids And Lipoproteins Pathway 160976!!PPAR Signaling Pathway 83042!!PPAR Signaling Pathway 450!!Statin Pathway 198852

Apolipoprotein C-III is a very low density lipoprotein (VLDL) protein. APOC3 inhibits lipoprotein lipase and hepatic lipase; it is thought to delay catabolism of triglyceride-rich particles. The APOA1, APOC3 and APOA4 genes are closely linked in both rat and human genomes. The A-I and A-IV genes are transcribed from the same strand, while the A-1 and C-III genes are convergently transcribed. An increase in apoC-III levels induces the development of hypertriglyceridemia. [provided by RefSeq]

Function: Inhibits lipoprotein lipase and hepatic lipase and decreases the uptake of lymph chylomicrons by hepatic cells. This suggests that it delays the catabolism of triglyceride-rich particles. Subcellular location: Secreted. Tissue specificity: Constitutes 50% of the protein fraction of VLDL and 2% of that of HDL. Synthesized predominantly in liver and to a lesser degree in intestine. Post-translational modification: O-linked glycan consists of Gal-GalNAc disaccharide, further modified with up to 3 sialic acid residues. O-glycosylated on Thr-94 with a core 1 or possibly core 8 glycan. Ref.9 Ref.10. Involvement in disease: Defects in APOC3 may be a cause of hyperalphalipoproteinemia (HYPALIP) [. MIM:143470]. Affected individuals show high levels of alpha-lipoprotein (high density lipoprotein/HDL). Ref.11. Sequence similarities: Belongs to the apolipoprotein C3 family.

1 ml

600 USD